PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DGUOK	1	SYP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STXBP1	38	STX1A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Bhaskar K (2004), Dulubova I (1999), McMahon HT (1995), Perez-Branguli F (2002), Barclay JW (2003), Ciufo LF (2005)	6
DGUOK	1	SNAP25	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TXLNB	0	STX1A	2	pull down, two hybrid	Nogami S (2004), Corominas R (2014)	2
PSMA3	1	CFTR	5	biochemical, affinity chromatography technology	Oberdorf J (2006), Pankow S (2015)	2
STX1A	2	CCSER2	4	two hybrid	Stelzl U (2005)	1
NAPA	2	VAMP2	3	pull down, biochemical	Hanson PI (1995), Havugimana PC (2012)	2
STX1A	2	VAPB	2	pull down, affinity chromatography technology	Li G (2003), Baron Y (2014)	2
STX1A	2	VAMP1	0	two hybrid	Perez-Branguli F (2002)	1
OIP5	1	STX1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX1A	2	VIM	0	two hybrid	Stelzl U (2005)	1
KCNB1	11	SNAP25	8	pull down	MacDonald PE (2002)	1
CDR2	1	TXLNA	3	two hybrid	Rolland T (2014)	1
STX1A	2	CDK5	0	pull down	Shuang R (1998)	1
STXBP6	0	STX1A	2	affinity chromatography technology	Huttlin EL (2017)	1
UNC13B	8	STX1A	2	two hybrid, biochemical	Betz A (1997), Betz A (1997)	2
SCNN1A	1	SCNN1G	2	affinity chromatography technology	Buck TM (2017)	1
STX1A	2	SCNN1A	1	affinity chromatography technology	Berdiev BK (2004)	1
DGUOK	1	SYT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NAPA	2	SNAP25	8	pull down	Hanson PI (1995)	1
VAMP1	0	VAPB	2	pull down	Nishimura Y (1999)	1
STX1A	2	NAPB	0	two hybrid	Corominas R (2014)	1
STX1A	2	SYP	0	affinity chromatography technology	McMahon HT (1995)	1
SNAP29	1	VAMP5	0	two hybrid	Rolland T (2014)	1
CPLX1	0	CPLX2	0	affinity chromatography technology	Huttlin EL (2017)	1
VAMP7	0	SNAP25	8	pull down	Martinez-Arca S (2003)	1
STXBP6	0	NAPA	2	affinity chromatography technology	Huttlin EL (2017)	1
VAMP7	0	SNAP23	0	affinity chromatography technology, pull down	Martinez-Arca S (2003), Galli T (1998)	2
TXLNA	3	TXLNB	0	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Li S (2011), Li S (2011), Rolland T (2014), Huttlin EL (2017)	4
STX1A	2	STX1A	2	pull down, two hybrid	Margittai M (1999), Corominas R (2014)	2
NUFIP1	0	STX1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP1CA	3	STX1A	2	affinity chromatography technology	Flores-Delgado G (2007)	1
VAMP1	0	SNAP29	1	two hybrid	Rolland T (2014)	1
SNAP23	0	STXBP5	7	pull down	Widberg CH (2003)	1
OIP5	1	RNF40	11	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX1A	2	SLC6A4	3	affinity chromatography technology	Quick MW (2002)	1
STX1A	2	SNAP23	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid	Imai A (2003), Li G (2003), Araki S (1997), Araki S (1997), Ravichandran V (1996), Steegmaier M (1998), Corominas R (2014)	7
STX1A	2	CPLX2	0	affinity chromatography technology	Dulubova I (1999)	1
STX1A	2	SCNN1G	2	affinity chromatography technology, pull down	Berdiev BK (2004), Berdiev BK (2004)	2
SLC6A2	3	STX1A	2	affinity chromatography technology	Dipace C (2007)	1
CFTR	5	HAX1	1	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
ATP6V1B1	4	VAMP7	0	affinity chromatography technology	Nylandsted J (2011)	1
SYTL4	0	STXBP1	38	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Fukuda M (2003), Ciufo LF (2005), van Breevoort D (2014), van Breevoort D (2014)	4
CFTR	5	VIM	0	affinity chromatography technology	Pankow S (2015)	1
HAX1	1	SYT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX1A	2	TXLNA	3	pull down, two hybrid	Nogami S (2003), Corominas R (2014)	2
DGUOK	1	NAPB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DGUOK	1	VAMP2	3	affinity chromatography technology	Huttlin EL (2015)	1
STX1A	2	STXBP5	7	pull down, pull down	Widberg CH (2003), Fujita Y (1998)	2
STX1A	2	391257	0	two hybrid	Corominas R (2014)	1
DGUOK	1	STXBP1	38	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NUFIP1	0	SYT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VAMP2	3	VAMP8	0	pull down	Polgar J (2002)	1
SCNN1B	1	SCNN1G	2	protein complementation assay	Faria D (2012)	1
NUFIP1	0	NAPB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CFTR	5	VAPB	2	affinity chromatography technology	Pankow S (2015)	1
NUFIP1	0	VAMP2	3	affinity chromatography technology	Huttlin EL (2015)	1
SNAP23	0	VAMP2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Imai A (2003), Paumet F (2000), Kawanishi M (2000), Kawanishi M (2000)	4
HAX1	1	SYP	0	affinity chromatography technology	Huttlin EL (2015)	1
SEC22B	0	VAPB	2	biochemical	Havugimana PC (2012)	1
SYT1	4	STX1A	2	pull down, pull down, pull down	Shao X (1997), Thomas DM (1999), Thomas DM (1999)	3
NUFIP1	0	SNAP25	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VAMP7	0	STX1A	2	pull down	Martinez-Arca S (2003)	1
SEC22B	0	STX1A	2	two hybrid	Petkovic M (2014)	1
VAMP2	3	SYT1	4	affinity chromatography technology	Zhang Q (2012)	1
SEC22B	0	NAPA	2	affinity chromatography technology	Huttlin EL (2017)	1
ATP6V1B1	4	VAMP8	0	affinity chromatography technology	Nylandsted J (2011)	1
SNAP29	1	RNF40	11	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX1A	2	ATP6V1B1	4	pull down	Li G (2003)	1
STX1A	2	VAMP8	0	pull down, affinity chromatography technology	Nagamatsu S (2001), Nagamatsu S (2001)	2
RNF40	11	STX1A	2	pull down, affinity chromatography technology	Chin LS (2002), Chin LS (2002)	2
STX1A	2	CFTR	5	pull down, affinity chromatography technology, affinity chromatography technology	Naren AP (1997), Naren AP (1997), Cormet-Boyaka E (2002)	3
SNAP25	8	STX1A	2	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005), Dulubova I (1999), McMahon HT (1995), Gonelle-Gispert C (2000), Gonelle-Gispert C (2000), Ilardi JM (1999), Li Y (2001), Ravichandran V (1996), Chapman ER (1994), Chapman ER (1994), Chen X (2002), Steegmaier M (1998), Darios F (2010)	14
STX1A	2	SNAP29	1	pull down, two hybrid	Steegmaier M (1998), Corominas R (2014)	2
STX1A	2	NAPA	2	affinity chromatography technology, pull down	McMahon HT (1995), Hanson PI (1995)	2
SYT1	4	SNAP25	8	pull down, pull down, affinity chromatography technology	Gerona RR (2000), Zhang X (2002), Zhang Q (2012)	3
STXBP1	38	CDK5	0	affinity chromatography technology	Bhaskar K (2004)	1
VAMP2	3	VAPB	2	pull down	Nishimura Y (1999)	1
UNC13B	8	VAMP2	3	biochemical	Betz A (1997)	1
SNAP29	1	STXBP5	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNAP23	0	VAMP8	0	affinity chromatography technology, affinity chromatography technology	Imai A (2003), Paumet F (2000)	2
STX1A	2	SLC6A3	6	pull down, affinity chromatography technology, affinity chromatography technology	Binda F (2008), Binda F (2008), Cartier E (2015)	3
STX1A	2	SLC6A1	27	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Beckman ML (1998), Quick MW (2002), Deken SL (2000), Deken SL (2000)	4
SEC22B	0	VAMP2	3	biochemical	Havugimana PC (2012)	1
CPLX1	0	SNAP25	8	x-ray crystallography, pull down	Chen X (2002), Hu K (2002)	2
VIM	0	TXLNB	0	two hybrid	Rolland T (2014)	1
CDR2	1	STX1A	2	affinity chromatography technology	Huttlin EL (2017)	1
SNAP23	0	NAPB	0	two hybrid	Rolland T (2014)	1
NUFIP1	0	STXBP1	38	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX1A	2	VAMP5	0	two hybrid	Corominas R (2014)	1
UNC13B	8	SNAP25	8	biochemical	Betz A (1997)	1
SNAP25	8	VAMP2	3	affinity chromatography technology, pull down, two hybrid, far western blotting, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Li Y (2001), Hao JC (1997), Hao JC (1997), Hao JC (1997), Chen X (2002), Zhang Q (2012), Zhang Q (2012)	7
DNAAF2	2	SYP	0	affinity chromatography technology	Huttlin EL (2015)	1
SNAP25	8	STXBP1	38	biochemical	Wan C (2015)	1
STX1A	2	SCNN1B	1	affinity chromatography technology	Berdiev BK (2004)	1
SNAP29	1	NAPA	2	biochemical	Wan C (2015)	1
HAX1	1	NAPB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SLC6A5	4	STX1A	2	affinity chromatography technology	Geerlings A (2000)	1
CPLX1	0	VAMP2	3	x-ray crystallography	Chen X (2002)	1
STXBP6	0	SNAP23	0	affinity chromatography technology	Huttlin EL (2017)	1
SYTL4	0	STX1A	2	affinity chromatography technology, affinity chromatography technology, pull down	Fukuda M (2003), Torii S (2002), Torii S (2002)	3
HAX1	1	STXBP1	38	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DGUOK	1	STX1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SCNN1B	1	SCNN1A	1	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Faria D (2012), Faria D (2012), Faria D (2012), Buck TM (2017)	4
DNAAF2	2	STXBP1	38	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNAP23	0	NAPA	2	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
DNAAF2	2	SNAP25	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX1A	2	VAMP2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, two hybrid, far western blotting, x-ray crystallography	Dulubova I (1999), McMahon HT (1995), Perez-Branguli F (2002), Margittai M (1999), Hao JC (1997), Hao JC (1997), Hao JC (1997), Chen X (2002)	8
DNAAF2	2	SYT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SLC6A9	1	STX1A	2	affinity chromatography technology	Geerlings A (2000)	1
NUFIP1	0	SYP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNAP23	0	VAMP5	0	two hybrid	Rolland T (2014)	1
STX1A	2	PSMA3	1	two hybrid	Corominas R (2014)	1
DNAAF2	2	NAPB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRDMT1	1	STX1A	2	two hybrid	Stelzl U (2005)	1
VAMP2	3	SNAP29	1	two hybrid	Rolland T (2014)	1
STX1A	2	CPLX1	0	affinity chromatography technology, x-ray crystallography, pull down	Dulubova I (1999), Chen X (2002), Hu K (2002)	3
STX1A	2	KCNB1	11	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Dai XQ (2012), Dai XQ (2012), Leung YM (2005), Leung YM (2005)	4
VAMP7	0	SNAP29	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Martinez-Arca S (2003), Huttlin EL (2015), Huttlin EL (2017)	3
CFTR	5	SNAP23	0	affinity chromatography technology, pull down	Cormet-Boyaka E (2002), Cormet-Boyaka E (2002)	2
HAX1	1	STX1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNAAF2	2	STX1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NAPA	2	VAMP8	0	pull down	Wong SH (1998)	1