Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
STX4	6810	PHENPROCOUMON	CHEMBL16694		PharmGKB

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
STX4	rs10871454	T	warfarin	dosage	yes	This SNP accounted for ~25% of the variance in stabilized warfarin dose in a GWAS study. It was in perfect linkage disequilibrium (r2=1) with rs9923231 (VKORC1:-1639)	Allele T is associated with decreased dose of warfarin.	18535201	608431827
STX4	rs10871454	T	phenprocoumon	dosage	yes	Each additional VKORC1 variant allele reduced phenprocoumon maintenance dosage by 4.8 mg/week (P<0.0001) compared to wild type. The study found additive effects of the variant alleles of CYP2C9 (rs4086116) and CYP4F2 (rsrs2108622) on VKORC1.	Allele T is associated with decreased dose of phenprocoumon maintenance dosage by 4.8 mg/week as compared to allele C.	21063236	827807849
STX4	rs10871454	T	acenocoumarol	dosage	yes	from a GWAS study consisting of the index population of 1451 Caucasian subjects from the Rotterdam study and results were replicated in 287 subjects from the Rotterdam study extended cohort. Results were reported as dosage change of -5.2mg/week per additional variant allele but allele was not specified, assumed T based on MAF from dbSNP. The SNP rs10871454 was in complete LD in our RS-I cohort with rs9934338 (VKORC1,1173C>T,r2=0.99).	Allele T is associated with decreased dose of acenocoumarol as compared to allele C.	19578179	1444706925