Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
ABCC8 6833 REPAGLINIDE CHEMBL1272 inhibitor, blocker TdgClinicalTrial, ChemblInteractions, DrugBank 11728565, 11716850, 15380228, 12196472, 15219283, 10773014
ABCC8 6833 TOLBUTAMIDE SODIUM, STERILE CHEMBL1200874 blocker ChemblInteractions
ABCC8 6833 GLIQUIDONE CHEMBL383634 inhibitor DrugBank 11484080, 11078469, 11078468, 11574406, 12475777
ABCC8 6833 MITIGLINIDE CHEMBL471498 inhibitor TdgClinicalTrial, DrugBank 17592198, 17003348, 11716850
ABCC8 6833 ADENOSINE TRIPHOSPHATE CHEMBL14249 DrugBank 17325510, 16931986, 16897043, 17457130
ABCC8 6833 GLIMEPIRIDE CHEMBL1481 inducer, blocker TdgClinicalTrial, ChemblInteractions, DrugBank 8911984, 8529521, 8172912
ABCC8 6833 TOLAZAMIDE CHEMBL817 blocker ChemblInteractions, DrugBank 8799949, 10354277
ABCC8 6833 GLYMIDINE CHEMBL1697838 inducer DrugBank 12031979, 12145099, 12213059, 12107069, 9990013, 12213829
ABCC8 6833 SARAKALIM CHEMBL2104449 ChemblInteractions
ABCC8 6833 NAMINIDIL CHEMBL2105160 ChemblInteractions
ABCC8 6833 NATEGLINIDE CHEMBL783 inhibitor, blocker TdgClinicalTrial, ChemblInteractions, DrugBank 11728565, 12764427, 11716850, 12196472, 12604678, 10773014
ABCC8 6833 GLYBURIDE CHEMBL472 blocker TdgClinicalTrial, ChemblInteractions, DrugBank 12031979, 12145099, 12213059, 12107069, 9990013, 17015627, 12213829
ABCC8 6833 GLIPIZIDE CHEMBL1073 inhibitor, blocker ChemblInteractions, DrugBank 11484080, 11078469, 11078468, 11574406, 12475777
ABCC8 6833 GLICLAZIDE CHEMBL427216 binder DrugBank 11484080, 11078469, 11078468, 11574406, 12475777
ABCC8 6833 ACETOHEXAMIDE CHEMBL1589 blocker ChemblInteractions
ABCC8 6833 TOLBUTAMIDE CHEMBL782 inhibitor, blocker ChemblInteractions, DrugBank 18220763
ABCC8 6833 CHLORPROPAMIDE CHEMBL498 inhibitor, blocker ChemblInteractions, DrugBank 18220763

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ABCC8 rs2237991 A tacrolimus metabolism/PK no This study was attempting to validate reported variants and tacrolimus trough concentration in a large population of African American and European American kidney transplant patients. Allele A is not associated with trough concentration of tacrolimus in people with Kidney Transplantation and Transplantation as compared to allele G. 29318894 1449163228
ABCC8 rs757110 C glibenclamide dosage no Allele C is not associated with dose of glibenclamide, gliclazide, glimepiride, glipizide and gliquidone in people with Diabetes Mellitus as compared to allele A. 24442125 1184470133
ABCC8 rs757110 AA + CC sulfonamides, urea derivatives efficacy yes The AC genotype was associated with increased response to sulfonylureas (a greater than or equal to 7% decrease in Hb1Ac levels at least 3 months after beginning treatment). Genotypes AA + CC is associated with increased response to sulfonamides, urea derivatives in people with Diabetes Mellitus as compared to genotype AC. 29681852 1449310630