PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STX4	2	SNAP29	1	pull down	Steegmaier M (1998)	1
STX7	2	STX8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Antonin W (2000), Antonin W (2000), Huttlin EL (2015), Huttlin EL (2017)	4
SIRT2	1	VAMP7	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX3	3	SNAP23	0	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, pull down, pull down	Imai A (2003), Imai A (2003), Imai A (2003), Araki S (1997), Araki S (1997), Ravichandran V (1996), Steegmaier M (1998), Vogel GF (2015)	8
STX3	3	SNAP29	1	two hybrid, pull down	Steegmaier M (1998), Steegmaier M (1998)	2
PPP2R1A	8	RAB11A	4	affinity chromatography technology	Sablina AA (2007)	1
STX4	2	STX12	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
STX7	2	STX3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMEM17	0	AP3M1	2	bioid	Gupta GD (2015)	1
STX7	2	STX12	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX7	2	SNAP23	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX4	2	STX6	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	4
STX12	2	VAMP7	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VAMP7	0	STX4	2	affinity chromatography technology	Martinez-Arca S (2003)	1
STX4	2	STX8	0	two hybrid	Rolland T (2014)	1
VAMP7	0	ANKRD27	4	pull down, affinity chromatography technology	Burgo A (2009), Burgo A (2009)	2
TMEM17	0	STX7	2	bioid	Gupta GD (2015)	1
VAMP7	0	AP3M1	2	affinity chromatography technology	Martinez-Arca S (2003)	1
VAMP7	0	SNAP25	8	pull down	Martinez-Arca S (2003)	1
STX3	3	STX8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK6	1	VAMP7	0	affinity chromatography technology	Rodriguez J (2016)	1
STX7	2	SNAP29	1	pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Steegmaier M (1998), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
VAMP7	0	SNAP23	0	affinity chromatography technology, pull down	Martinez-Arca S (2003), Galli T (1998)	2
TMEM17	0	SNAP23	0	bioid	Gupta GD (2015)	1
AP3M1	2	AP3D1	7	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kristensen AR (2012), Ivan V (2012), Wan C (2015), Huttlin EL (2017)	4
STX7	2	STX6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wade N (2001), Huttlin EL (2015), Huttlin EL (2017)	3
STX6	0	STX12	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX1A	2	SNAP23	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid	Imai A (2003), Li G (2003), Araki S (1997), Araki S (1997), Ravichandran V (1996), Steegmaier M (1998), Corominas R (2014)	7
STX3	3	SNAP25	8	pull down, pull down	Ravichandran V (1996), Steegmaier M (1998)	2
ATP6V1B1	4	VAMP7	0	affinity chromatography technology	Nylandsted J (2011)	1
ATP6V1B1	4	STX8	0	affinity chromatography technology	Nylandsted J (2011)	1
SNAP23	0	STX12	2	pull down, affinity chromatography technology, affinity chromatography technology	Tang BL (1998), Huttlin EL (2015), Huttlin EL (2017)	3
STX3	3	STX4	2	two hybrid	Rolland T (2014)	1
MAPK6	1	STX7	2	two hybrid	Vinayagam A (2011)	1
RAB11A	4	STX3	3	affinity chromatography technology, affinity chromatography technology	Vogel GF (2015), Vogel GF (2015)	2
MAPK6	1	PPP2R1A	8	two hybrid	Vinayagam A (2011)	1
VAMP7	0	PPP2R1A	8	affinity chromatography technology	Boldt K (2016)	1
VAMP7	0	STX6	0	affinity chromatography technology	Gordon DE (2009)	1
RAB11A	4	VAMP7	0	affinity chromatography technology	Vogel GF (2015)	1
TMEM17	0	STX8	0	bioid	Gupta GD (2015)	1
VAMP7	0	STX1A	2	pull down	Martinez-Arca S (2003)	1
STX12	2	SNAP29	1	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Steegmaier M (1998), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
STX1A	2	ATP6V1B1	4	pull down	Li G (2003)	1
SNAP25	8	STX1A	2	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005), Dulubova I (1999), McMahon HT (1995), Gonelle-Gispert C (2000), Gonelle-Gispert C (2000), Ilardi JM (1999), Li Y (2001), Ravichandran V (1996), Chapman ER (1994), Chapman ER (1994), Chen X (2002), Steegmaier M (1998), Darios F (2010)	14
STX4	2	STX7	2	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	4
STX1A	2	SNAP29	1	pull down, two hybrid	Steegmaier M (1998), Corominas R (2014)	2
STX4	2	SNAP23	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, biochemical	Imai A (2003), Imai A (2003), Imai A (2003), Li G (2003), Araki S (1997), Araki S (1997), Araki S (1997), Paumet F (2000), Paumet F (2000), Ravichandran V (1996), Kawanishi M (2000), Kawanishi M (2000), Steegmaier M (1998), Freedman SJ (2003), Havugimana PC (2012)	15
SNAP25	8	STX12	2	affinity chromatography technology	Hirling H (2000)	1
ATP6V1B1	4	STX12	2	affinity chromatography technology	Nylandsted J (2011)	1
STX12	2	STX8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VAMP7	0	STX8	0	affinity chromatography technology	Gordon DE (2009)	1
VAMP7	0	AP3D1	7	two hybrid, affinity chromatography technology	Martinez-Arca S (2003), Martinez-Arca S (2003)	2
STX6	0	SNAP29	1	affinity chromatography technology	Huttlin EL (2015)	1
SNAP23	0	STX6	0	pull down, affinity chromatography technology, affinity chromatography technology	Martin-Martin B (2000), Martin-Martin B (2000), Huttlin EL (2015)	3
STX6	0	STX8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX3	3	VAMP7	0	affinity chromatography technology	Vogel GF (2015)	1
VAMP7	0	STX7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gordon DE (2009), Huttlin EL (2015), Huttlin EL (2017)	3
MAPK6	1	AP3D1	7	affinity chromatography technology	Rodriguez J (2016)	1
STX4	2	SNAP25	8	pull down, pull down, affinity chromatography technology, pull down	Ravichandran V (1996), Reed GL (1999), Reed GL (1999), Steegmaier M (1998)	4
STX6	0	STX3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMEM17	0	STX6	0	bioid	Gupta GD (2015)	1
GINM1	1	VAMP7	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VAMP7	0	SNAP29	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Martinez-Arca S (2003), Huttlin EL (2015), Huttlin EL (2017)	3
TMEM17	0	STX12	2	bioid	Gupta GD (2015)	1
TMEM17	0	VAMP7	0	bioid	Gupta GD (2015)	1