PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DGUOK	1	SNAP25	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX4	2	SYT1	4	pull down	Thomas DM (1999)	1
SYT1	4	SV2B	7	affinity chromatography technology	Lazzell DR (2004)	1
SYT1	4	EIF2B2	0	affinity chromatography technology	Huttlin EL (2017)	1
RRP7A	1	SYT1	4	affinity chromatography technology	Huttlin EL (2017)	1
DGUOK	1	SYT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IKBKG	0	SYT1	4	pull down, affinity chromatography technology, two hybrid	Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010)	3
STX4	2	VAMP2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid	Paumet F (2000), Mollinedo F (2003), Jagadish MN (1996), Reed GL (1999), Rolland T (2014)	5
SYT2	1	SYNCRIP	6	pull down	Mizutani A (2000)	1
STX3	3	SYT1	4	pull down	Thomas DM (1999)	1
ARMC1	2	SYT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005)	2
EIF2B2	0	EIF2B5	3	pull down, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Anthony TG (2000), Anthony TG (2000), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	6
EIF2B2	0	EIF2B3	0	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	5
EIF2B2	0	GOLM1	1	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	SYNCRIP	6	affinity chromatography technology	Emdal KB (2015)	1
SYT1	4	SV2C	2	affinity chromatography technology	Lazzell DR (2004)	1
EIF2B2	0	EIF2B4	4	biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Rolland T (2014), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	5
NUFIP1	0	STX1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SYT1	4	EIF2B5	3	affinity chromatography technology	Huttlin EL (2017)	1
SYT1	4	EIF2B3	0	affinity chromatography technology	Huttlin EL (2017)	1
SYT1	4	PGK2	2	affinity chromatography technology	Huttlin EL (2017)	1
SYT1	4	SYT2	1	affinity chromatography technology	Huttlin EL (2017)	1
SYT1	4	LRP2	13	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	EIF2B5	3	affinity chromatography technology	Emdal KB (2015)	1
STX3	3	SNAP25	8	pull down, pull down	Ravichandran V (1996), Steegmaier M (1998)	2
GOLM1	1	SYT1	4	two hybrid	Stelzl U (2005)	1
STX2	1	SYT1	4	pull down	Thomas DM (1999)	1
NEDD4	2	SYT1	4	pull down	Persaud A (2009)	1
RBM14	5	SYT1	4	pull down, pull down	Iwasaki T (2005), Iwasaki T (2005)	2
SYT1	4	C6orf15	1	affinity chromatography technology	Lazzell DR (2004)	1
STX3	3	STX4	2	two hybrid	Rolland T (2014)	1
HAX1	1	SYT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DGUOK	1	VAMP2	3	affinity chromatography technology	Huttlin EL (2015)	1
NUFIP1	0	SYT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX2	1	VAMP2	3	two hybrid	Imai A (2003)	1
STON2	2	SYT1	4	pull down, pull down	Martina JA (2001), Walther K (2001)	2
NUFIP1	0	VAMP2	3	affinity chromatography technology	Huttlin EL (2015)	1
NTRK1	1	EIF2B4	4	affinity chromatography technology	Emdal KB (2015)	1
S100A13	0	FGF1	0	biochemical, pull down	Mouta Carreira C (1998), Landriscina M (2001)	2
CALM1	0	SYT1	4	pull down	Perin MS (1996)	1
SYT1	4	STX1A	2	pull down, pull down, pull down	Shao X (1997), Thomas DM (1999), Thomas DM (1999)	3
NUFIP1	0	SNAP25	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
S100A13	0	SYT1	4	biochemical, pull down	Mouta Carreira C (1998), Landriscina M (2001)	2
VAMP2	3	SYT1	4	affinity chromatography technology	Zhang Q (2012)	1
CALM1	0	ARMC1	2	pull down	Shen X (2005)	1
SNAP25	8	STX1A	2	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005), Dulubova I (1999), McMahon HT (1995), Gonelle-Gispert C (2000), Gonelle-Gispert C (2000), Ilardi JM (1999), Li Y (2001), Ravichandran V (1996), Chapman ER (1994), Chapman ER (1994), Chen X (2002), Steegmaier M (1998), Darios F (2010)	14
C6orf15	1	SV2B	7	affinity chromatography technology	Lazzell DR (2004)	1
SYT1	4	SYNCRIP	6	pull down	Mizutani A (2000)	1
SYT1	4	CWC22	3	affinity chromatography technology	Huttlin EL (2017)	1
SYT1	4	SIN3A	13	two hybrid, pull down	Ito T (2004), Ito T (2004)	2
SYT1	4	SNAP25	8	pull down, pull down, affinity chromatography technology	Gerona RR (2000), Zhang X (2002), Zhang Q (2012)	3
NTRK1	1	SIN3A	13	affinity chromatography technology	Emdal KB (2015)	1
STON2	2	SYT2	1	affinity chromatography technology, pull down	Martina JA (2001), Martina JA (2001)	2
EIF2B3	0	EIF2B5	3	pull down, biochemical, biochemical	Anthony TG (2000), Havugimana PC (2012), Wan C (2015)	3
SYT1	4	EIF2B4	4	affinity chromatography technology	Huttlin EL (2017)	1
SMAD2	5	SYT1	4	pull down	Miyamoto-Sato E (2010)	1
SYT1	4	CACNA1A	21	pull down	Charvin N (1997)	1
SNAP25	8	VAMP2	3	affinity chromatography technology, pull down, two hybrid, far western blotting, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Li Y (2001), Hao JC (1997), Hao JC (1997), Hao JC (1997), Chen X (2002), Zhang Q (2012), Zhang Q (2012)	7
NEDD4	2	NTRK1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Arevalo JC (2006), Arevalo JC (2006), Arevalo JC (2006), Georgieva MV (2011), Georgieva MV (2011), Persaud A (2009), Persaud A (2009), Emdal KB (2015)	8
NTRK1	1	CWC22	3	affinity chromatography technology	Emdal KB (2015)	1
SYT5	0	SYT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX3	3	VAMP2	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Imai A (2003), Huttlin EL (2015), Huttlin EL (2017)	3
STX2	1	SNAP25	8	pull down	Ravichandran V (1996)	1
CALM1	0	VAMP2	3	biochemical	Havugimana PC (2012)	1
SYT1	4	FGF1	0	pull down	Landriscina M (2001)	1
STX4	2	SNAP25	8	pull down, pull down, affinity chromatography technology, pull down	Ravichandran V (1996), Reed GL (1999), Reed GL (1999), Steegmaier M (1998)	4
EIF2B4	4	EIF2B3	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Boldt K (2016)	3
NTRK1	1	RBM14	5	affinity chromatography technology	Emdal KB (2015)	1
DGUOK	1	STX1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EIF2B4	4	EIF2B5	3	pull down, biochemical, biochemical, affinity chromatography technology	Anthony TG (2000), Havugimana PC (2012), Wan C (2015), Boldt K (2016)	4
CDCA8	0	SYT1	4	affinity chromatography technology	Huttlin EL (2017)	1
SYT1	4	VLDLR	3	affinity chromatography technology	Huttlin EL (2017)	1
DNAAF2	2	SNAP25	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX1A	2	VAMP2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, two hybrid, far western blotting, x-ray crystallography	Dulubova I (1999), McMahon HT (1995), Perez-Branguli F (2002), Margittai M (1999), Hao JC (1997), Hao JC (1997), Hao JC (1997), Chen X (2002)	8
DNAAF2	2	SYT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	HAX1	1	affinity chromatography technology	Emdal KB (2015)	1
CALM1	0	DNAAF2	2	affinity chromatography technology	Boldt K (2016)	1
NTRK1	1	SYT1	4	affinity chromatography technology	Emdal KB (2015)	1
HAX1	1	STX1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNAAF2	2	STX1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2