PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TAF8	2	TAF7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guermah M (2003), Huttlin EL (2015), Huttlin EL (2017), Gupta K (2017)	4
TBP	0	TAF7L	1	affinity chromatography technology	Pointud JC (2003)	1
HIST3H3	0	TAF8	2	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
TAF8	2	TAF12	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST3H3	0	TBP	0	unspecified method	Vermeulen M (2010)	1
HIST3H3	0	TAF7	0	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
TBP	0	TAF12	0	pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down	Knuesel MT (2009), Liu X (2008), Denissov S (2007), Wieczorek E (1998), Hoffmann A (1996), Hoffmann A (1996)	6
MED26	2	TAF7	0	affinity chromatography technology	Takahashi H (2011)	1
MED26	2	TAF8	2	affinity chromatography technology	Takahashi H (2011)	1
GTF2A1	1	TBP	0	pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	DeJong J (1995), Langelier MF (2001), Ozer J (1998), Solow S (2001), Sun X (1994), Jeronimo C (2007), Maldonado E (1990), Mitsiou DJ (2003), Mitsiou DJ (2003), Huttlin EL (2015), Huttlin EL (2017), Gupta K (2017)	12
TAF4B	1	RELA	1	pull down, pull down	Yamit-Hezi A (1998), Yamit-Hezi A (1998)	2
HIST3H3	0	TAF12	0	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
TAF11	0	TAF12	0	affinity chromatography technology	Gupta K (2017)	1
TAF1	9	TAF7	0	two hybrid, pull down, biochemical, affinity chromatography technology	Gegonne A (2001), Gegonne A (2001), Havugimana PC (2012), Gupta K (2017)	4
HIST3H3	0	TAF11	0	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
TAF11	0	TAF4B	1	affinity chromatography technology	Gupta K (2017)	1
TBP	0	TAF4B	1	affinity chromatography technology	Dikstein R (1996)	1
TAF7L	1	TAF1	9	two hybrid, affinity chromatography technology	Pointud JC (2003), Huttlin EL (2017)	2
RELA	1	TAF1	9	pull down	Guermah M (1998)	1
TAF4B	1	GTF2A1	1	pull down	Shao H (2005)	1
TBP	0	TAF11	0	biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, biochemical, biochemical, pull down, affinity chromatography technology	Bellorini M (1997), Mengus G (1995), May M (1996), Knuesel MT (2009), Liu X (2008), Demeny MA (2007), Wieczorek E (1998), Brand M (1999), Gupta K (2017), Gupta K (2017)	10
TAF11	0	TAF7	0	affinity chromatography technology, affinity chromatography technology	Gupta K (2017), Gupta K (2017)	2
TAF8	2	TAF1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guermah M (2003), Huttlin EL (2015), Huttlin EL (2017), Gupta K (2017)	4
TAF8	2	KPNB1	3	pull down	Soutoglou E (2005)	1
TAF1	9	GTF2A1	1	enzymatic study	Solow S (2001)	1
TAF7L	1	TAF4B	1	affinity chromatography technology	Huttlin EL (2017)	1
ILKAP	2	TAF4B	1	affinity chromatography technology	Yadav L (2017)	1
TAF7	0	TAF12	0	affinity chromatography technology	Gupta K (2017)	1
HIST3H3	0	TAF1	9	affinity chromatography technology, affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2007), Vermeulen M (2010)	3
MED26	2	TAF11	0	affinity chromatography technology	Takahashi H (2011)	1
RELA	1	TBP	0	pull down, pull down, genetic interference, affinity chromatography technology	Guermah M (1998), Schmitz ML (1995), Schmitz ML (1995), Rojo-Niersbach E (2000)	4
BACH1	3	TAF4B	1	affinity chromatography technology	Hein MY (2015)	1
HIST3H3	0	TAF4B	1	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
TAF7L	1	TAF12	0	affinity chromatography technology	Huttlin EL (2017)	1
TAF7	0	TAF4B	1	affinity chromatography technology	Gupta K (2017)	1
TAF8	2	TAF11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guermah M (2003), Huttlin EL (2017), Gupta K (2017)	3
TAF4B	1	TAF1	9	pull down, affinity chromatography technology	Shao H (2005), Gupta K (2017)	2
TBP	0	TAF7	0	affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pointud JC (2003), Bellorini M (1997), Knuesel MT (2009), Wieczorek E (1998), Dantonel JC (1997), Dantonel JC (1997), Kamileri I (2012), Gupta K (2017)	8
TAF7L	1	TAF11	0	affinity chromatography technology	Huttlin EL (2017)	1
MED26	2	TBP	0	affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011)	2
TBP	0	TAF8	2	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Liu X (2008), Demeny MA (2007), Demeny MA (2007), Guermah M (2003), Bhatnagar A (2013)	5
KPNB1	3	TAF11	0	affinity chromatography technology	Hein MY (2015)	1
TAF1	9	TBP	0	pull down, biochemical, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Siegert JL (1999), Bellorini M (1997), Ruppert S (1993), OBrien T (1998), Knuesel MT (2009), Hilton TL (2005), Liu X (2008), Demeny MA (2007), Dikstein R (1996), Wieczorek E (1998), Dantonel JC (1997), Klemm RD (1995), Dallas PB (1997), Ogryzko VV (1998), Gupta K (2017)	15
KPNB1	3	TAF4B	1	affinity chromatography technology	Hein MY (2015)	1
TAF11	0	TAF1	9	affinity chromatography technology, affinity chromatography technology	Gupta K (2017), Gupta K (2017)	2
TAF4B	1	TAF12	0	pull down, pull down	Shao H (2005), Shao H (2005)	2
TAF7L	1	TAF8	2	affinity chromatography technology	Huttlin EL (2017)	1
MED26	2	TAF1	9	affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011)	2
MED26	2	TAF4B	1	affinity chromatography technology	Takahashi H (2011)	1
RELA	1	TAF11	0	pull down	Guermah M (1998)	1
TAF8	2	TAF4B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2