PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKCA	7	TBXA2R	1	enzymatic study, enzymatic study	Zhou H (2001), Yan FX (2002)	2
TBXA2R	1	GNB1	4	fluorescent resonance energy transfe, pull down	Gales C (2005), Manganello JM (2003)	2
PRKG1	3	TBXA2R	1	enzymatic study	Reid HM (2003)	1
TBXA2R	1	GNAS	9	fluorescent resonance energy transfe	Gales C (2005)	1
NME2	0	PSMA7	1	affinity chromatography technology	Ewing RM (2007)	1
PLCB2	0	GNAQ	1	affinity chromatography technology	Cartier A (2011)	1
GRK5	7	YWHAZ	1	affinity chromatography technology	Wu Z (2012)	1
GNG2	0	GNA13	0	affinity chromatography technology	Manganello JM (2003)	1
PRKACA	2	GNA13	0	enzymatic study	Manganello JM (2003)	1
PRKCA	7	RACK1	2	affinity chromatography technology	Lee HS (2002)	1
PLCB2	0	TBXA2R	1	affinity chromatography technology	Cartier A (2011)	1
YWHAZ	1	PRKCA	7	affinity chromatography technology	Gannon-Murakami L (2002)	1
GNG2	0	GNAI2	1	affinity chromatography technology	Stallmeyer B (2017)	1
RACK1	2	GNG2	0	affinity chromatography technology, affinity chromatography technology	Sun Z (2011), Knezevic N (2009)	2
TBXA2R	1	YWHAZ	1	two hybrid, far western blotting, affinity chromatography technology	Yan W (2006), Yan W (2006), Yan W (2006)	3
GNB1	4	GNAS	9	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Gales C (2005), Huttlin EL (2015), Huttlin EL (2017)	3
TBXA2R	1	PRDX4	0	two hybrid, affinity chromatography technology, pull down	Giguere P (2007), Giguere P (2007), Giguere P (2007)	3
TBXA2R	1	GNA11	2	affinity chromatography technology, affinity chromatography technology	Rochdi MD (2002), Frey AJ (2013)	2
TBXA2R	1	GPRASP1	5	pull down	Simonin F (2004)	1
PTGIR	3	TBXA2R	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Wilson SJ (2004), Wilson SJ (2004), Frey AJ (2013), Ibrahim S (2010)	4
TBXA2R	1	KCNMB1	1	affinity chromatography technology, affinity chromatography technology	Li M (2013), Li M (2013)	2
GNA12	2	TBXA2R	1	affinity chromatography technology	Offermanns S (1994)	1
YWHAZ	1	RAF1	3	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Clark GJ (1997), Tzivion G (2000), Tzivion G (2000), Koyama S (1995), Koyama S (1995), Van Der Hoeven PC (2000), Chow CW (2000), Andersen SD (2012), Subramanian RR (2001), Wang H (1998), Wang H (1998), Wang H (1998), Dougherty MK (2005), Rajalingam K (2005), Zhu J (2005), So J (2015), Powell DW (2003), Ivanov AA (2017)	18
TBXA2R	1	PSME3	0	affinity chromatography technology, two hybrid, two hybrid	Sasaki M (2007), Sasaki M (2007), Nakahata N (2007)	3
GNB1	4	GNAQ	1	biochemical	Wan C (2015)	1
RHOA	0	PKN1	4	pull down, two hybrid, pull down, two hybrid, far western blotting, pull down, x-ray crystallography	Riento K (2003), Riento K (2003), Alberts AS (1998), Flynn P (1998), Flynn P (1998), Flynn P (1998), Maesaki R (1999)	7
PRKACA	2	YWHAZ	1	enzymatic study, pull down	Gu YM (2006), Gu YM (2006)	2
PLCB2	0	WDR36	0	affinity chromatography technology	Cartier A (2011)	1
TBXA2R	1	GNG2	0	fluorescent resonance energy transfe	Gales C (2005)	1
TBXA2R	1	RACK1	2	two hybrid, pull down, affinity chromatography technology	Parent A (2008), Parent A (2008), Parent A (2008)	3
TBXA2R	1	NME2	0	affinity chromatography technology, two hybrid, pull down	Rochdi MD (2004), Rochdi MD (2004), Rochdi MD (2004)	3
KCNMB1	1	KCNMA1	10	affinity chromatography technology	Li M (2013)	1
GNG2	0	GNB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, fluorescent resonance energy transfe	Snow BE (1999), Poon LS (2009), Snow BE (1998), Howlett AC (2009), Lukov GL (2005), Howlett AC (2009), Gales C (2005), Rosskopf D (2003), Zhou JY (2003)	9
TBXA2R	1	PSMA7	1	affinity chromatography technology, two hybrid, two hybrid	Sasaki M (2007), Sasaki M (2007), Nakahata N (2007)	3
PTGIR	3	GNAQ	1	affinity chromatography technology	Miggin SM (2002)	1
TBXA2R	1	WDR36	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Cartier A (2011), Cartier A (2011), Cartier A (2011), Cartier A (2011)	4
GNB1	4	GNAI2	1	fluorescent resonance energy transfe, biochemical	Gibson SK (2006), Havugimana PC (2012)	2
RACK1	2	RHOA	0	two hybrid	Wang J (2011)	1
RACK1	2	GNB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun Z (2011), Chen S (2008), Knezevic N (2009)	3
GRK6	3	TBXA2R	1	enzymatic study	Zhou H (2001)	1
GNA11	2	GNAS	9	biochemical	Havugimana PC (2012)	1
GNA13	0	TBXA2R	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down	Offermanns S (1994), Gales C (2005), Manganello JM (1999), Manganello JM (2003)	4
TBXA2R	1	ARRB2	5	affinity chromatography technology	Kelley-Hickie LP (2006)	1
TBXA2R	1	PKN1	4	two hybrid, pull down, affinity chromatography technology	Turner EC (2011), Turner EC (2011), Turner EC (2011)	3
GNB1	4	GNA11	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TBXA2R	1	TBXA2R	1	two hybrid, affinity chromatography technology, biochemical, imaging technique, fluorescent resonance energy transfe, affinity chromatography technology, imaging technique, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology	Nakahata N (2007), Laroche G (2005), Laroche G (2005), Fanelli F (2011), Fanelli F (2011), Sasaki M (2006), Sasaki M (2006), Frey AJ (2013), Ibrahim S (2010), Wilson SJ (2007)	10
TBXA2R	1	RAF1	3	affinity chromatography technology	Yan W (2006)	1
GNAS	9	GNA12	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPGRIP1L	2	RAF1	3	affinity chromatography technology	Boldt K (2016)	1
PTGIR	3	GNAS	9	x-ray crystallography, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Zhang L (2006), Miggin SM (2002), Zhang L (2005), Nobles M (2005)	4
PSMA7	1	PSME3	0	biochemical	Havugimana PC (2012)	1
TBXA2R	1	AAMP	3	two hybrid, pull down, affinity chromatography technology	Reid HM (2011), Reid HM (2011), Reid HM (2011)	3
TBXA2R	1	GNAI2	1	fluorescent resonance energy transfe	Gales C (2005)	1
RAF1	3	PRKG1	3	affinity chromatography technology	Zaragoza C (2002)	1
PTGIR	3	RAB11A	4	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Wikstroem K (2008), Wikstroem K (2008), Turner EC (2011), Reid HM (2010)	4
TBXA2R	1	RAB11A	4	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, imaging technique	Reid HM (2010), Hamelin E (2005), Hamelin E (2005), Hamelin E (2005), Theriault C (2004)	5
TBXA2R	1	RPGRIP1L	2	two hybrid, affinity chromatography technology, pull down	Tokue S (2009), Tokue S (2009), Tokue S (2009)	3
TBXA2R	1	GHRL	1	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Chow KB (2008), Chow KB (2008), Chow KB (2008)	3
TBXA2R	1	GNAQ	1	fluorescent resonance energy transfe, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gales C (2005), Cartier A (2011), Chillar A (2010), Chillar A (2010), Manganello JM (2003), Theriault C (2004), Kelley LP (2003), Sikarwar AS (2013)	8
GNG2	0	GNAS	9	affinity chromatography technology	Nagai Y (2010)	1
TBXA2R	1	RHOA	0	affinity chromatography technology	Turner EC (2011)	1
SIVA1	0	TBXA2R	1	affinity chromatography technology, affinity chromatography technology	Iorio-Morin C (2012), Iorio-Morin C (2012)	2
TBXA2R	1	KCNMA1	10	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Li M (2010), Li M (2010), Li M (2010), Li M (2013)	4
PRKCA	7	PTGIR	3	enzymatic study	Smyth EM (1998)	1
GNAQ	1	GNAS	9	biochemical	Havugimana PC (2012)	1
ARRB2	5	RAF1	3	affinity chromatography technology	Luttrell LM (2001)	1
WDR36	0	GNAQ	1	affinity chromatography technology	Cartier A (2011)	1
GRK6	3	GRK5	7	affinity chromatography technology	Huttlin EL (2017)	1
PTGIR	3	GHRL	1	affinity chromatography technology, affinity chromatography technology	Chow KB (2008), Chow KB (2008)	2
PRKACA	2	TBXA2R	1	enzymatic study	Reid HM (2003)	1
GRK5	7	TBXA2R	1	enzymatic study	Zhou H (2001)	1