PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FYN	1	SYK	3	affinity chromatography technology, pull down	Deckert M (1998), Deckert M (1998)	2
BTK	1	STAT5A	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Mahajan S (2001), Mahajan S (2001), Mahajan S (2001), Mahajan S (2001)	4
CBL	7	HCK	5	affinity chromatography technology, enzymatic study, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, unspecified method	Howlett CJ (2002), Howlett CJ (1999), Howlett CJ (1999), Howlett CJ (1999), Howlett CJ (1999), Anderson SM (1997), Liu BA (2012)	7
BTK	1	BCL2L11	4	pull down	Hirano M (2004)	1
ARRB1	2	JAK1	6	affinity chromatography technology	Ewing RM (2007)	1
HSP90AA1	7	RPS6KB1	1	affinity chromatography technology	Taipale M (2012)	1
GRB2	2	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
BTK	1	IRAK1	1	affinity chromatography technology	Jefferies CA (2003)	1
CBLB	3	VAV1	2	affinity chromatography technology, two hybrid, pull down, far western blotting, affinity chromatography technology	Sattler M (2002), Bustelo XR (1997), Bustelo XR (1997), Bustelo XR (1997), Bustelo XR (1997)	5
BTK	1	SPTA1	10	affinity chromatography technology	Li Y (2011)	1
BCL2L11	4	AURKA	1	affinity chromatography technology	Moustafa-Kamal M (2013)	1
MED28	2	HCK	5	affinity chromatography technology	Lu M (2006)	1
CDC37	0	APP	1	two hybrid	Soler-Lopez M (2011)	1
HSP90AA1	7	BTK	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Huttlin EL (2017)	2
GRB2	2	KHDRBS1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology, two hybrid	Liu SK (1998), Oneyama C (2002), Shen Z (1999), Shen Z (1999), Bandyopadhyay S (2010), Asbach B (2012), Bisson N (2011), Wang J (2011)	8
BTK	1	TUBB4B	6	affinity chromatography technology	Li Y (2011)	1
KHDRBS1	1	HCK	5	unspecified method, affinity chromatography technology, fluorescent resonance energy transfe	Asbach B (2012), Asbach B (2012), Asbach B (2012)	3
RPS6KB2	3	DDX3X	52	affinity chromatography technology	Roy R (2014)	1
EWSR1	2	HRNR	18	bioid	Elzi DJ (2014)	1
BTK	1	EWSR1	2	affinity chromatography technology	Guinamard R (1997)	1
PLCG2	11	SYK	3	affinity chromatography technology	Guo B (2000)	1
LYN	2	RPS6KB1	1	enzymatic study	Rebholz H (2006)	1
MYD88	1	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen BC (2002), Wesche H (1999), Li S (2002), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011), Neumann D (2007), Zhou J (2011), Burns K (2003), Mizobe T (2007), Loiarro M (2007), Choi KC (2006), Rao N (2005), Rao N (2005), Li CH (2006)	15
SMURF1	4	MRPS22	0	affinity chromatography technology	Xie Y (2013)	1
FYN	1	3327	0	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	TUBB4B	6	affinity chromatography technology	Brehme M (2009)	1
LYN	2	PRKCB	4	affinity chromatography technology	Zhu J (2013)	1
ARHGAP17	1	BTK	1	pull down	Richnau N (2001)	1
BTK	1	CAV1	0	affinity chromatography technology, affinity chromatography technology	Vargas L (2002), Vargas L (2002)	2
ATP5A1	0	ATP5B	0	biochemical, two hybrid, biochemical, affinity chromatography technology	Havugimana PC (2012), Rolland T (2014), Wan C (2015), Huttlin EL (2017)	4
HSP90AA1	7	LYN	2	affinity chromatography technology	Taipale M (2012)	1
DBN1	1	ACTN1	5	affinity chromatography technology	Hein MY (2015)	1
MED28	2	BTK	1	affinity chromatography technology	Lu M (2006)	1
MYC	2	IRAK1	1	affinity chromatography technology	Koch HB (2007)	1
FYN	1	KHDRBS1	1	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study	Oneyama C (2002), Fusaki N (1997), Loewenberg M (2006), Asbach B (2012), Asbach B (2012), Kaabeche K (2004)	6
CBLB	3	PLCG2	11	affinity chromatography technology	Yasuda T (2002)	1
SYK	3	PRKD1	7	affinity chromatography technology	Sidorenko SP (1996)	1
PIK3R3	0	FYN	1	two hybrid	Grossmann A (2015)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
ARRB1	2	HSP90AA1	7	affinity chromatography technology	Xiao K (2007)	1
FASLG	0	FYN	1	pull down, pull down, pull down, unspecified method, imaging technique	Wenzel J (2001), Hane M (1995), Zuccato E (2007), Voss M (2009), Chen TC (2014)	5
BTK	1	CBL	7	pull down, x-ray crystallography, unspecified method, affinity chromatography technology	Cory GO (1995), Tzeng SR (2000), Patel HV (1997), Morrogh LM (1999)	4
BTK	1	CORO1C	2	affinity chromatography technology	Li Y (2011)	1
TLR4	5	IRAK1	1	affinity chromatography technology	Yang M (2011)	1
BTK	1	HCK	5	pull down	Cheng G (1994)	1
GRB2	2	BTK	1	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009)	2
EWSR1	2	GAPDH	0	affinity chromatography technology	Elzi DJ (2014)	1
IRAK1	1	ATP5B	0	affinity chromatography technology	So J (2015)	1
HSP90AA1	7	ACTN1	5	affinity chromatography technology	Falsone SF (2005)	1
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
AURKA	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
BTK	1	ATP5A1	0	affinity chromatography technology	Li Y (2011)	1
KATNB1	0	BTK	1	affinity chromatography technology	Huttlin EL (2017)	1
RPS6KB2	3	SFPQ	2	affinity chromatography technology	Roy R (2014)	1
TIRAP	1	BTK	1	affinity chromatography technology	Jefferies CA (2003)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
ARRB1	2	FLNA	10	affinity chromatography technology	Xiao K (2007)	1
PLCG2	11	VAV1	2	affinity chromatography technology	Guo B (2000)	1
ARRB1	2	ATP5A1	0	affinity chromatography technology	Xiao K (2007)	1
HSP90AA1	7	TUBB4B	6	affinity chromatography technology	Skarra DV (2011)	1
BTK	1	GTF2I	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Sacristan C (2004), Sacristan C (2004), Novina CD (1999), Yang W (1997), Yang W (1997), Hirano M (2004), Egloff AM (2001)	7
MYC	2	BTK	1	genetic interference	Toyoshima M (2012)	1
BLNK	2	SYK	3	affinity chromatography technology, affinity chromatography technology	Oellerich T (2011), Janda E (2011)	2
BTK	1	KHDRBS1	1	affinity chromatography technology, unspecified method	Guinamard R (1997), Asbach B (2012)	2
FASLG	0	GRB2	2	affinity chromatography technology, pull down, pull down	Ghadimi MP (2002), Ghadimi MP (2002), Wenzel J (2001)	3
KHDRBS1	1	LYN	2	unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study	Asbach B (2012), Asbach B (2012), Asbach B (2012), Kaabeche K (2004)	4
BTK	1	NDUFS1	4	affinity chromatography technology	Li Y (2011)	1
CBLB	3	MYD88	1	affinity chromatography technology	Han C (2010)	1
GRB2	2	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
FYN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loewenberg M (2006), Taipale M (2012), Taipale M (2012), Huttlin EL (2017)	4
BTK	1	EEF1A2	18	affinity chromatography technology	Li Y (2011)	1
TLR4	5	SYK	3	affinity chromatography technology	Lin YC (2013)	1
BTK	1	3327	0	affinity chromatography technology	Huttlin EL (2017)	1
BTK	1	1820	0	affinity chromatography technology, affinity chromatography technology	Nixon JC (2004), Nixon JC (2004)	2
SH3BP5	0	BTK	1	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Matsushita M (1998), Matsushita M (1998), Yamadori T (1999), Yamadori T (1999)	4
PRKCB	4	IBTK	3	enzymatic study, affinity chromatography technology	Janda E (2011), Janda E (2011)	2
CBL	7	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
GRB2	2	GAPDH	0	affinity chromatography technology	Brehme M (2009)	1
TIRAP	1	TLR4	5	affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, protein complementation assay, affinity chromatography technology, protein complementation assay, protein complementation assay, affinity chromatography technology	Horng T (2001), Horng T (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Ulrichts P (2007), Ulrichts P (2007), Ulrichts P (2008), Ulrichts P (2010), Li S (2011)	9
PIK3R3	0	BTK	1	two hybrid	Grossmann A (2015)	1
CDC37	0	TTC9C	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
TWF1	2	APP	1	pull down	Olah J (2011)	1
LYN	2	ANKRD54	0	affinity chromatography technology, affinity chromatography technology	Zhu J (2013), Zhu J (2013)	2
IRAK1	1	CAV1	0	affinity chromatography technology	Ohnuma K (2005)	1
GNB1	4	ARRB1	2	affinity chromatography technology, pull down	Yang M (2009), Yang M (2009)	2
BTK	1	ATP5B	0	affinity chromatography technology	Li Y (2011)	1
GRB2	2	FLNA	10	affinity chromatography technology	Bisson N (2011)	1
STAT5A	4	CBL	7	affinity chromatography technology, two hybrid	Dieudonne FX (2013), Grossmann A (2015)	2
RPS6KB2	3	TUBB4B	6	affinity chromatography technology	Roy R (2014)	1
MYD88	1	SYK	3	affinity chromatography technology	Lin YC (2013)	1
MYC	2	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GRB2	2	WAS	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Banin S (1996), She HY (1997), She HY (1997), She HY (1997)	4
TLR9	2	SYK	3	affinity chromatography technology	Lin YC (2013)	1
BTK	1	MRPS22	0	two hybrid	Grossmann A (2015)	1
RPS6KB1	1	APP	1	pull down	Olah J (2011)	1
MYD88	1	TLR9	2	two hybrid, affinity chromatography technology	Chuang TH (2004), Yang M (2011)	2
HSP90AA1	7	MYLK2	1	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Taipale M (2012)	2
BLNK	2	VAV1	2	affinity chromatography technology	Fu C (1998)	1
CBL	7	TUBB4B	6	affinity chromatography technology	Brehme M (2009)	1
GNB1	4	GNAQ	1	biochemical	Wan C (2015)	1
BTK	1	GNAQ	1	pull down, affinity chromatography technology	Ma YC (1998), Ma YC (1998)	2
BTK	1	TLR9	2	two hybrid	Jefferies CA (2003)	1
BTK	1	TTC9C	2	affinity chromatography technology	Huttlin EL (2017)	1
RPS6KB2	3	HSP90AA1	7	affinity chromatography technology	Roy R (2014)	1
BTK	1	IBTK	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Liu W (2001), Liu W (2001), Janda E (2011), Spatuzza C (2008)	4
AURKA	1	TUBB4B	6	affinity chromatography technology	Fogeron ML (2013)	1
JAK1	6	GRB2	2	affinity chromatography technology, pull down	Kim H (2001), Giorgetti-Peraldi S (1995)	2
SYK	3	RPS6KB2	3	enzymatic study	Rebholz H (2006)	1
BTK	1	TUBA4A	1	affinity chromatography technology	Li Y (2011)	1
KHDRBS1	1	VAV1	2	unspecified method	Asbach B (2012)	1
EWSR1	2	ARHGAP17	1	bioid	Elzi DJ (2014)	1
WAS	0	CBLB	3	affinity chromatography technology	Watanabe Y (2013)	1
BTK	1	HRNR	18	affinity chromatography technology	Li Y (2011)	1
DBN1	1	FLNA	10	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015), Hein MY (2015)	3
BTK	1	SYK	3	affinity chromatography technology	Morrogh LM (1999)	1
APP	1	MYC	2	pull down	Virok DP (2011)	1
ATP5B	0	NDUFS1	4	biochemical	Havugimana PC (2012)	1
BLNK	2	CBL	7	affinity chromatography technology, far western blotting	Yasuda T (2000), Yasuda T (2000)	2
FYN	1	PLCG2	11	pull down	Pleiman CM (1993)	1
ARRB1	2	ACTA1	1	affinity chromatography technology	Xiao K (2007)	1
BCL2L11	4	GTF2I	1	pull down	Hirano M (2004)	1
FYN	1	CAV1	0	biochemical	Mastick CC (1997)	1
BTK	1	PLCG2	11	affinity chromatography technology, affinity chromatography technology	Yasuda T (2002), Guo B (2000)	2
BLNK	2	LYN	2	affinity chromatography technology	Oellerich T (2011)	1
BTK	1	PRKD1	7	affinity chromatography technology, affinity chromatography technology, pull down	Johannes FJ (1999), Johannes FJ (1999), Johannes FJ (1999)	3
BCL2L11	4	APP	1	pull down	Olah J (2011)	1
BTK	1	BLNK	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yasuda T (2002), Hashimoto S (1999), Hashimoto S (1999), Oellerich T (2011), Janda E (2011)	5
SFPQ	2	KHDRBS1	1	biochemical	Wan C (2015)	1
CBL	7	CBLB	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Rorsman C (2016)	2
FYN	1	CBLB	3	two hybrid	Grossmann A (2015)	1
BTK	1	SFPQ	2	affinity chromatography technology	Li Y (2011)	1
PLCG2	11	PRKD1	7	affinity chromatography technology	Sidorenko SP (1996)	1
MYD88	1	BTK	1	affinity chromatography technology	Jefferies CA (2003)	1
RPS6KB2	3	GTF2I	1	affinity chromatography technology	Roy R (2014)	1
HSP90AA1	7	HCK	5	affinity chromatography technology	Taipale M (2012)	1
BTK	1	MYLK2	1	affinity chromatography technology	Li Y (2011)	1
RPS6KB2	3	KRT5	1	affinity chromatography technology	Roy R (2014)	1
FYN	1	CBL	7	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Taher TE (2002), Deckert M (1998), Deckert M (1998), Deckert M (1998), Ghosh AK (2004), Rellahan BL (2003), Boussiotis VA (1997), Andoniou CE (2000), Shishido T (2000), Okabe S (2006), Kaabeche K (2004), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tanaka S (1995), Reedquist KA (1996), Grossmann AH (2004), Panchamoorthy G (1996), Fukazawa T (1995), Fukazawa T (1995), Fukazawa T (1995), Nishio H (2002), Anderson SM (1997), Fukazawa T (1996), Grossmann A (2015)	27
ACTA1	1	SPTA1	10	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
BTK	1	PLAU	1	two hybrid	Wang J (2011)	1
CBL	7	SPTA1	10	affinity chromatography technology	Brehme M (2009)	1
BTK	1	BTK	1	x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Mao C (2001), Egloff AM (2001), Morrogh LM (1999), Morrogh LM (1999), Park H (1996)	5
CBL	7	VAV1	2	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marengere LE (1997), Marengere LE (1997), Marengere LE (1997), Marengere LE (1997), Bertagnolo V (2001), Miura-Shimura Y (2003), Simmons A (2005), Shen M (2009), Shen M (2009), Lottin-Divoux S (2006), Lottin-Divoux S (2006), Peterson ME (2008)	12
SYK	3	RPS6KB1	1	enzymatic study	Rebholz H (2006)	1
AURKA	1	BTK	1	pull down	Kamran M (2017)	1
CBLB	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Ettenberg SA (1999), Lavagna-Sevenier C (1998), Lavagna-Sevenier C (1998), Elly C (1999), Bandyopadhyay S (2010), Vinayagam A (2011), Bisson N (2011), Blagoev B (2003), Rolland T (2014), Huttlin EL (2017)	10
BTK	1	ANKRD54	0	affinity chromatography technology	Huttlin EL (2017)	1
HADHA	3	TUBB4B	6	biochemical	Havugimana PC (2012)	1
BTK	1	RPS6KB1	1	enzymatic study	Rebholz H (2006)	1
BTK	1	GAPDH	0	affinity chromatography technology	Li Y (2011)	1
RPS6KB2	3	RPS3	0	affinity chromatography technology	Roy R (2014)	1
CDC37	0	EEF1A2	18	affinity chromatography technology	Li J (2013)	1
ATP5B	0	HSP90AA1	7	biochemical	Wan C (2015)	1
ARHGAP17	1	GRB2	2	pull down	Richnau N (2001)	1
GRB2	2	DBN1	1	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
BTK	1	BECN1	2	two hybrid	Grossmann A (2015)	1
FLNA	10	TWF1	2	affinity chromatography technology	Hein MY (2015)	1
VAV1	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Song JS (1996), Ye ZS (1994), Ye ZS (1994), Germani A (1999), Lee IS (1997)	5
AURKA	1	RPS3	0	affinity chromatography technology	Fogeron ML (2013)	1
BTK	1	HADHA	3	affinity chromatography technology	Li Y (2011)	1
CBL	7	ACTN1	5	affinity chromatography technology	Brehme M (2009)	1
CBL	7	SYK	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Lupher ML (1998), Lupher ML (1998), Bertagnolo V (2001), Melander F (2003), Macglashan D (2004), Rao N (2001), Rao N (2001), Yankee TM (1999), Saci A (2000), Moon KD (2005), Lottin-Divoux S (2006), Grossmann AH (2004), Ota S (2000), Ota S (2000), Panchamoorthy G (1996), Marcilla A (1995), Justa-Schuch D (2016)	17
HSP90AA1	7	TTC9C	2	affinity chromatography technology	Gano JJ (2010)	1
ACTA1	1	RPS6KB1	1	pull down	Berven LA (2004)	1
HSP90AA1	7	BECN1	2	affinity chromatography technology	Xu C (2011)	1
TIRAP	1	MYD88	1	genetic interference, two hybrid, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, protein complementation assay, protein complementation assay, protein complementation assay, affinity chromatography technology	Fitzgerald KA (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Ulrichts P (2007), Ulrichts P (2007), Ulrichts P (2008), Ulrichts P (2010), Ulrichts P (2010), Ulrichts P (2010)	10
BTK	1	GNB1	4	affinity chromatography technology	Lowry WE (2002)	1
BTK	1	DDX3X	52	affinity chromatography technology	Li Y (2011)	1
BTK	1	FLNA	10	affinity chromatography technology	Li Y (2011)	1
EWSR1	2	GTF2I	1	affinity chromatography technology	Elzi DJ (2014)	1
HSP90AA1	7	GAPDH	0	affinity chromatography technology, biochemical	Falsone SF (2005), Wan C (2015)	2
IBTK	3	RPS3	0	affinity chromatography technology	Hein MY (2015)	1
MYD88	1	TLR4	5	two hybrid, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, protein complementation assay, protein complementation assay, affinity chromatography technology	Chuang TH (2004), Doyle SE (2003), Rhee SH (2000), Fitzgerald KA (2001), Ulrichts P (2007), Ulrichts P (2008), Ulrichts P (2010), Yang M (2011)	8
SMURF1	4	JAK1	6	affinity chromatography technology	Xie Y (2013)	1
GTF2I	1	MYC	2	pull down, affinity chromatography technology, affinity chromatography technology	Roy AL (1993), Roy AL (1993), Koch HB (2007)	3
TIRAP	1	IRAK1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
MED28	2	FYN	1	affinity chromatography technology	Lu M (2006)	1
ARHGAP17	1	APP	1	pull down	Olah J (2011)	1
BTK	1	CDC37	0	affinity chromatography technology	Huttlin EL (2017)	1
AFG3L2	0	APP	1	pull down	Olah J (2011)	1
SH3BP5	0	APP	1	pull down	Olah J (2011)	1
AURKA	1	EEF1A2	18	affinity chromatography technology	Fogeron ML (2013)	1
FLNA	10	SYK	3	imaging technique	Justa-Schuch D (2016)	1
CBL	7	GAPDH	0	affinity chromatography technology	Feshchenko EA (2004)	1
HSP90AA1	7	FLNA	10	affinity chromatography technology	Falsone SF (2005)	1
3327	0	HSP90AA1	7	biochemical	Havugimana PC (2012)	1
MYC	2	NDUFS1	4	affinity chromatography technology	Koch HB (2007)	1
DBN1	1	CAV1	0	affinity chromatography technology	Hein MY (2015)	1
LYN	2	CBL	7	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Taher TE (2002), Dombrosky-Ferlan PM (1997), Kaabeche K (2004), Wu J (2008), Tanaka S (1995), Marcilla A (1995)	6
BTK	1	TLR4	5	two hybrid	Jefferies CA (2003)	1
HSP90AA1	7	ATP5A1	0	biochemical	Wan C (2015)	1
SMURF1	4	BTK	1	enzymatic study	Andrews PS (2010)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
GAPDH	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
BTK	1	APP	1	pull down	Olah J (2011)	1
LYN	2	PIK3R3	0	affinity chromatography technology, affinity chromatography technology	Zhu J (2013), Zhu J (2013)	2
RPS6KB2	3	MRPS22	0	affinity chromatography technology	Roy R (2014)	1
IRAK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, biochemical	De Nardo D (2005), De Nardo D (2005), De Nardo D (2005)	3
MYC	2	TUBA4A	1	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Agrawal P (2010)	2
BTK	1	MAP3K4	1	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	JAK1	6	affinity chromatography technology	Taipale M (2012)	1
HCK	5	APP	1	pull down	Olah J (2011)	1
MYC	2	MRPS22	0	affinity chromatography technology	Koch HB (2007)	1
JAK1	6	BTK	1	affinity chromatography technology	Takahashi-Tezuka M (1997)	1
1820	0	APP	1	pull down	Olah J (2011)	1
BTK	1	TLR8	2	two hybrid	Jefferies CA (2003)	1
SMURF1	4	MYD88	1	affinity chromatography technology, affinity chromatography technology	Lee YS (2011), Lee YS (2011)	2
FYN	1	VAV1	2	affinity chromatography technology, two hybrid	Michel F (1998), Tartare-Deckert S (2001)	2
EWSR1	2	CDC37	0	bioid	Elzi DJ (2014)	1
APP	1	TIRAP	1	two hybrid	Wang J (2011)	1
MYC	2	HADHA	3	affinity chromatography technology	Hein MY (2015)	1
BTK	1	TWF1	2	affinity chromatography technology	Li Y (2011)	1
SFPQ	2	EWSR1	2	affinity chromatography technology	Huttlin EL (2017)	1
BTK	1	LYN	2	pull down	Cheng G (1994)	1
SYK	3	VAV1	2	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Deckert M (1996), Deckert M (1996), Deckert M (1996), Song JS (1996), Bertagnolo V (2001), Bertagnolo V (2001), Tartare-Deckert S (2001)	7
CDC37	0	HCK	5	affinity chromatography technology	Scholz GM (2001)	1
LYN	2	FASLG	0	pull down, unspecified method	Zuccato E (2007), Voss M (2009)	2
ATP5A1	0	APP	1	pull down	Olah J (2011)	1
TIRAP	1	JAK1	6	affinity chromatography technology	Li S (2011)	1
AFG3L2	0	ATP5A1	0	biochemical	Wan C (2015)	1
HSP90AA1	7	PRKCB	4	affinity chromatography technology	Taipale M (2012)	1
SYK	3	LYN	2	affinity chromatography technology, pull down	Sidorenko SP (1995), Sidorenko SP (1995)	2
ARRB1	2	ATP5B	0	affinity chromatography technology	Xiao K (2007)	1
GRB2	2	SYK	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Saci A (2002), de Castro RO (2012), de Castro RO (2012)	4
ARRB1	2	BTK	1	two hybrid	Wang J (2011)	1
BTK	1	440915	0	affinity chromatography technology	Li Y (2011)	1
DBN1	1	CORO1C	2	affinity chromatography technology	Hein MY (2015)	1
BLNK	2	PLCG2	11	affinity chromatography technology, affinity chromatography technology	Oellerich T (2011), Oellerich T (2011)	2
BTK	1	KRT5	1	affinity chromatography technology	Li Y (2011)	1
BTK	1	TLR6	0	two hybrid	Jefferies CA (2003)	1
SYK	3	APP	1	pull down	Olah J (2011)	1
IRAK1	1	CDC37	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	De Nardo D (2005), De Nardo D (2005), De Nardo D (2005), De Nardo D (2005)	4
JAK1	6	STAT5A	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997)	4
LYN	2	RPS6KB2	3	enzymatic study	Rebholz H (2006)	1
HCK	5	PIK3R3	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
EWSR1	2	KHDRBS1	1	bioid	Elzi DJ (2014)	1
SMURF1	4	TUBB4B	6	affinity chromatography technology	Xie Y (2013)	1
FYN	1	CDC37	0	affinity chromatography technology	Huttlin EL (2017)	1
TLR9	2	IRAK1	1	affinity chromatography technology	Yang M (2011)	1
HCK	5	WAS	0	pull down	Scott MP (2002)	1
MYC	2	HCK	5	genetic interference	Toyoshima M (2012)	1
BTK	1	WAS	0	pull down, affinity chromatography technology	Cory GO (1996), Morrogh LM (1999)	2
TUBA4A	1	TUBB4B	6	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
AURKA	1	CDC37	0	affinity chromatography technology	Fogeron ML (2013)	1
BTK	1	AFG3L2	0	affinity chromatography technology	Li Y (2011)	1
BECN1	2	AFG3L2	0	affinity chromatography technology	Behrends C (2010)	1
ARRB1	2	TUBA4A	1	affinity chromatography technology	Xiao K (2007)	1
BTK	1	RPS3	0	affinity chromatography technology	Li Y (2011)	1
MED28	2	GRB2	2	affinity chromatography technology, pull down	Wiederhold T (2004), Wiederhold T (2004)	2
HSP90AA1	7	CAV1	0	affinity chromatography technology	Ji Y (2007)	1
BTK	1	MPP7	2	biochemical	Wan C (2015)	1
AURKA	1	HSP90AA1	7	affinity chromatography technology	Fogeron ML (2013)	1
BTK	1	DBN1	1	affinity chromatography technology	Li Y (2011)	1
BTK	1	RPS6KB2	3	enzymatic study	Rebholz H (2006)	1
GNB1	4	FYN	1	affinity chromatography technology	Knezevic N (2009)	1
FASLG	0	HCK	5	unspecified method	Voss M (2009)	1
DDX3X	52	RPS3	0	biochemical	Kristensen AR (2012)	1
BTK	1	ACTA1	1	affinity chromatography technology	Li Y (2011)	1
APP	1	CAV1	0	biochemical, unspecified method	Ikezu T (1998), Ikezu T (1998)	2
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
BTK	1	PRKCB	4	pull down	Yang XL (2003)	1
AURKA	1	MRPS22	0	affinity chromatography technology	Fogeron ML (2013)	1
BTK	1	CBLB	3	affinity chromatography technology	Yasuda T (2002)	1
FASLG	0	SPTA1	10	unspecified method	Voss M (2009)	1
SMURF1	4	FLNA	10	affinity chromatography technology	Xie Y (2013)	1
FLNA	10	CORO1C	2	affinity chromatography technology	Hein MY (2015)	1
RPS6KB2	3	EWSR1	2	affinity chromatography technology	Roy R (2014)	1
SMURF1	4	RPS3	0	affinity chromatography technology	Xie Y (2013)	1
WAS	0	CBL	7	affinity chromatography technology	Watanabe Y (2013)	1
CAV1	0	TLR4	5	affinity chromatography technology, affinity chromatography technology	Wang P (2011), Wang P (2011)	2
KHDRBS1	1	PIK3R3	0	two hybrid	Wang J (2011)	1
ATP5A1	0	RPS3	0	biochemical	Havugimana PC (2012)	1
GRB2	2	PIK3R3	0	affinity chromatography technology	Bisson N (2011)	1
CBL	7	ACTA1	1	affinity chromatography technology	Valiya Veettil M (2011)	1
FASLG	0	BTK	1	unspecified method	Voss M (2009)	1
MYC	2	FLNA	10	affinity chromatography technology	Agrawal P (2010)	1
BTK	1	VAV1	2	affinity chromatography technology	Guinamard R (1997)	1
HSP90AA1	7	PRKD1	7	affinity chromatography technology	Taipale M (2012)	1
BTK	1	ACTN1	5	affinity chromatography technology	Li Y (2011)	1
RPS6KB2	3	CDC37	0	affinity chromatography technology	Roy R (2014)	1
ATP5A1	0	RPS6KB2	3	two hybrid, affinity chromatography technology	Wang J (2011), Roy R (2014)	2
ARRB1	2	EEF1A2	18	affinity chromatography technology	Xiao K (2007)	1
DBN1	1	TWF1	2	affinity chromatography technology	Hein MY (2015)	1
CBL	7	PIK3R3	0	two hybrid, two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015), Grossmann A (2015)	3
PRKD1	7	IBTK	3	enzymatic study, affinity chromatography technology	Janda E (2011), Janda E (2011)	2
BLNK	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Fu C (1998), Engels N (2001), Fusaki N (2000), Wienands J (1998), Oellerich T (2011), Oellerich T (2011)	6
PLCG2	11	LYN	2	affinity chromatography technology, pull down, affinity chromatography technology	Pleiman CM (1993), Pleiman CM (1993), Guo B (2000)	3
RPS6KB2	3	ACTA1	1	affinity chromatography technology	Roy R (2014)	1
FYN	1	WAS	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, enzymatic study	Banin S (1996), Banin S (1996), Banin S (1996), Banin S (1999), Rivero-Lezcano OM (1995), Suetsugu S (2002)	6
BTK	1	FYN	1	pull down	Cheng G (1994)	1
RPS3	0	HSP90AA1	7	pull down, affinity chromatography technology	Kim TS (2006), Kim TS (2006)	2
CBLB	3	SYK	3	affinity chromatography technology, enzymatic study	Elly C (1999), Wirnsberger G (2016)	2
CBL	7	CORO1C	2	affinity chromatography technology	Brehme M (2009)	1
NDUFS1	4	AFG3L2	0	biochemical	Wan C (2015)	1
MYC	2	PLAU	1	two hybrid	Wang J (2011)	1