PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ERBB2	6	JAK2	1	affinity chromatography technology	Ren Z (2002)	1
LYN	2	KIT	4	affinity chromatography technology, affinity chromatography technology, pull down	Liang X (2002), Linnekin D (1997), Linnekin D (1997)	3
KIT	4	PIK3R2	3	two hybrid	De Sepulveda P (1999)	1
TEC	2	KIT	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	van Dijk TB (2000), Tang B (1994), Tang B (1994), Tang B (1994)	4
ERBB2	6	DOK1	2	unspecified method	Jones RB (2006)	1
LYN	2	IKBKG	0	affinity chromatography technology	Lee SH (2012)	1
PIK3R2	3	SHC1	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
MED28	2	PIK3R2	3	affinity chromatography technology	Lu M (2006)	1
SHC1	0	TEC	2	affinity chromatography technology	Brehme M (2009)	1
FBXO7	1	ERBB2	6	enzymatic study	Teixeira FR (2016)	1
GRB2	2	TEC	2	affinity chromatography technology	Bisson N (2011)	1
JAK1	6	TEC	2	affinity chromatography technology	Takahashi-Tezuka M (1997)	1
SHC1	0	DOK1	2	affinity chromatography technology, affinity chromatography technology, unspecified method	Dunant NM (2000), Dunant NM (2000), Liu BA (2012)	3
WAS	0	RAC1	7	pull down	Kolluri R (1996)	1
TEC	2	LYN	2	affinity chromatography technology	van Dijk TB (2000)	1
FASLG	0	GRB2	2	affinity chromatography technology, pull down, pull down	Ghadimi MP (2002), Ghadimi MP (2002), Wenzel J (2001)	3
GRB2	2	SOCS1	1	pull down	De Sepulveda P (1999)	1
LYN	2	DOK1	2	enzymatic study, pull down, enzymatic study	van Dijk TB (2000), van Dijk TB (2000), Liang X (2002)	3
JAK2	1	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chauhan D (1995), Chauhan D (1995), Giorgetti-Peraldi S (1995), Brizzi MF (1996)	4
ERBB2	6	TEC	2	unspecified method	Jones RB (2006)	1
FBXO7	1	TEC	2	enzymatic study	Teixeira FR (2016)	1
LYN	2	JAK2	1	pull down	Chin H (1998)	1
GRB2	2	WAS	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Banin S (1996), She HY (1997), She HY (1997), She HY (1997)	4
TEC	2	GNA12	2	genetic interference, affinity chromatography technology	Suzuki N (2003), Suzuki N (2003)	2
SOCS1	1	ERBB2	6	unspecified method	Jones RB (2006)	1
KIT	4	GRB2	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down	De Sepulveda P (1999), Thoemmes K (1999), Feng GS (1996), Sun J (2007), Zhu MJ (2007), Wollberg P (2003), Brizzi MF (1996)	7
JAK1	6	GRB2	2	affinity chromatography technology, pull down	Kim H (2001), Giorgetti-Peraldi S (1995)	2
TEC	2	SOCS1	1	pull down, two hybrid	Ohya K (1997), Ohya K (1997)	2
JAK2	1	TEC	2	affinity chromatography technology, enzymatic study	Takahashi-Tezuka M (1997), Yamashita Y (1998)	2
JAK2	1	VAV1	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Shigematsu H (1997), Shigematsu H (1997), Matsuguchi T (1995)	3
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
ERBB2	6	VAV1	2	unspecified method	Jones RB (2006)	1
SHC1	0	JAK2	1	pull down, pull down	VanderKuur J (1995), Giordano V (1997)	2
RPE	3	TEC	2	biochemical	Wan C (2015)	1
TEC	2	WAS	0	pull down	Cory GO (1996)	1
TEC	2	ARHGEF12	2	genetic interference, enzymatic study	Suzuki N (2003), Suzuki N (2003)	2
GNA13	0	ARHGEF12	2	affinity chromatography technology, genetic interference	Fukuhara S (2000), Suzuki N (2003)	2
FASLG	0	TEC	2	unspecified method	Voss M (2009)	1
ERBB2	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Schulze WX (2006), Bourguignon LY (2001), Olayioye MA (1998), Li X (2007), Li X (2007), Crovello CS (1998), Jones RB (2006)	7
RAC1	7	VAV1	2	affinity chromatography technology	Kaminuma O (2001)	1
JAK1	6	SOCS1	1	affinity chromatography technology	Park ES (2000)	1
VAV1	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Song JS (1996), Ye ZS (1994), Ye ZS (1994), Germani A (1999), Lee IS (1997)	5
SOCS1	1	VAV1	2	affinity chromatography technology, affinity chromatography technology	De Sepulveda P (1999), De Sepulveda P (2000)	2
GNA12	2	ARHGEF12	2	affinity chromatography technology, genetic interference	Fukuhara S (2000), Suzuki N (2003)	2
KIT	4	SOCS1	1	two hybrid, affinity chromatography technology	De Sepulveda P (1999), De Sepulveda P (1999)	2
JAK2	1	SOCS1	1	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yasukawa H (1999), Dif F (2001), Endo TA (1997), Endo TA (1997), Endo TA (1997), Yasukawa H (1999), Yasukawa H (1999), Pezet A (1999), Ungureanu D (2002), Masuhara M (1997), Ali S (2003), Monni R (2001), Monni R (2001), Piessevaux J (2008), Yu L (2009), Maruoka M (2017)	16
TEC	2	VAV1	2	affinity chromatography technology	Kline JB (2001)	1
DOK1	2	VAV1	2	unspecified method	Liu BA (2012)	1
LYN	2	FASLG	0	pull down, unspecified method	Zuccato E (2007), Voss M (2009)	2
SORT1	1	TEC	2	affinity chromatography technology	Hein MY (2015)	1
ERBB2	6	PIK3R2	3	pull down, unspecified method	Gout I (1992), Jones RB (2006)	2
GRB2	2	DOK1	2	affinity chromatography technology	Kepley CL (2004)	1
KIT	4	JAK2	1	affinity chromatography technology	Brizzi MF (1994)	1
IKBKG	0	JAK2	1	pull down	Fenner BJ (2010)	1
MED28	2	GRB2	2	affinity chromatography technology, pull down	Wiederhold T (2004), Wiederhold T (2004)	2
GRB2	2	PIK3R2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
TEC	2	DOK1	2	affinity chromatography technology, enzymatic study, pull down, enzymatic study	van Dijk TB (2000), van Dijk TB (2000), van Dijk TB (2000), Liang X (2002)	4
ERBB2	6	JAK1	6	unspecified method	Jones RB (2006)	1
ERBB2	6	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid	Schulze WX (2006), Wong L (1999), Olayioye MA (1998), Crovello CS (1998), Jones RB (2006), Yao Z (2017)	6
RAC1	7	TEC	2	genetic interference	Kline JB (2001)	1
IKBKG	0	TEC	2	pull down	Fenner BJ (2010)	1
TEC	2	GNA13	0	genetic interference	Suzuki N (2003)	1
PRLR	0	TEC	2	affinity chromatography technology, affinity chromatography technology, pull down	Kline JB (2001), Kline JB (2001), Kline JB (2001)	3
PRLR	0	JAK2	1	affinity chromatography technology, affinity chromatography technology	Pezet A (1997), Ma L (2010)	2
TEC	2	PIK3R2	3	two hybrid	Takahashi-Tezuka M (1997)	1
LYN	2	SHC1	0	affinity chromatography technology	Ptasznik A (1995)	1
MED28	2	TEC	2	affinity chromatography technology	Lu M (2006)	1
DOK1	2	KIT	4	affinity chromatography technology, pull down	Liang X (2002), Liang X (2002)	2
RAC1	7	GRB2	2	affinity chromatography technology	Huttlin EL (2017)	1
PRLR	0	VAV1	2	pull down, affinity chromatography technology, affinity chromatography technology	Kline JB (2001), Clevenger CV (1995), Clevenger CV (1995)	3