PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCPH1	4	NR2F1	9	two hybrid	Liu X (2017)	1
AHR	3	NR2F1	9	pull down, pull down	Klinge CM (2000), Klinge CM (2001)	2
CD70	0	NR2F1	9	affinity chromatography technology	Huttlin EL (2017)	1
CBX5	3	BCL11B	3	affinity chromatography technology	Marban C (2005)	1
ELAVL1	0	TEAD2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ISL1	2	NR2F1	9	pull down	Gay F (2000)	1
COPS2	5	NR2F1	9	pull down	Dressel U (1999)	1
SP1	0	CBX5	3	pull down	Marban C (2005)	1
SP1	0	ESR1	0	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Koslowski M (2009), Jin W (2008), Dong J (2006), Dong J (2006), Castet A (2006), He S (2005), He S (2005), Varshochi R (2005), Varshochi R (2005), Petz LN (2004), Li D (2007), Itoh Y (2007), Saville B (2000), Gibson LL (2005)	14
GRK5	7	NR2F1	9	affinity chromatography technology	Wu Z (2012)	1
FOXA3	0	NR2F1	9	affinity chromatography technology	Li X (2015)	1
NR2F1	9	SP1	0	pull down, pull down	Rohr O (1997), Marban C (2005)	2
PHB2	1	NR2F1	9	pull down, pull down	Kurtev V (2004), Kurtev V (2004)	2
NR2F1	9	BCL11B	3	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Avram D (2000), Avram D (2000), Marban C (2005), Marban C (2005), Marban C (2005)	5
BCL11B	3	SP1	0	pull down, pull down, affinity chromatography technology	Marban C (2005), Marban C (2005), Marban C (2005)	3
FOS	0	NCOA3	3	pull down, affinity chromatography technology	Fauquier L (2008), Fauquier L (2008)	2
AHR	3	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study	Wormke M (2003), Klinge CM (2000), MacPherson L (2009), Beischlag TV (2005), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	8
FOS	0	NR2F1	9	affinity chromatography technology	Li X (2015)	1
SP1	0	AHR	3	pull down	Wang F (1999)	1
MPPED1	1	NR2F1	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	NR2F1	9	affinity chromatography technology	Abdelmohsen K (2009)	1
GRK5	7	COPS2	5	affinity chromatography technology	Wu Z (2012)	1
FOS	0	ESR1	0	affinity chromatography technology	Baron S (2007)	1
NCOA3	3	NCOA2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu RC (2002), Lodrini M (2008), Lodrini M (2008)	3
NR2F1	9	NCOA2	2	two hybrid	Sugiyama T (2000)	1
ESR1	0	NCOA2	2	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Waernmark A (2002), Waernmark A (2002), He B (2003), Fenne IS (2008), Fenne IS (2008), Cui Y (2006), Dutertre M (2003), Kindle KB (2005), Jaber BM (2004), Torchia J (1997), Yin H (2007), Monroe DG (2003), Bai Y (2003), Bramlett KS (2001), Kraichely DM (2000), Kraichely DM (2000), Eng FC (1998), Voegel JJ (1998), Nalvarte I (2010), Han SJ (2016), Han SJ (2016), MacPherson L (2009)	22
ESR1	0	GTF2B	1	pull down	Lazennec G (1997)	1
RNF13	0	NR2F1	9	affinity chromatography technology	Huttlin EL (2015)	1
FOS	0	NCOA2	2	pull down, affinity chromatography technology	Fauquier L (2008), Fauquier L (2008)	2
TEAD2	2	NR2F1	9	affinity chromatography technology	Li X (2015)	1
PFDN1	0	NR2F1	9	two hybrid	Vinayagam A (2011)	1
FOXL1	0	NR2F1	9	affinity chromatography technology	Li X (2015)	1
TFAP4	3	SP1	0	affinity chromatography technology, affinity chromatography technology	Ku WC (2009), Ku WC (2009)	2
ELAVL1	0	TFAP4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
NR2F1	9	NCOA3	3	two hybrid	Sugiyama T (2000)	1
ISL1	2	ESR1	0	affinity chromatography technology, pull down	Gay F (2000), Gay F (2000)	2
NR2F1	9	ESR1	0	affinity chromatography technology, pull down, two hybrid, pull down	Metivier R (2002), Metivier R (2002), Metivier R (2002), Klinge CM (1997)	4
ELAVL1	0	NCOA3	3	affinity chromatography technology	Abdelmohsen K (2009)	1
NSD1	25	ESR1	0	two hybrid	Chan CM (2013)	1
NCOA3	3	ESR1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Wong CW (2001), Tikkanen MK (2000), Tikkanen MK (2000), Feng Q (2006), Long X (2008), Long X (2008), Dutertre M (2003), Jaber BM (2004), Torchia J (1997), Torchia J (1997), Karmakar S (2010), Takeshita A (1997), Zhao HH (2001), Wu RC (2004), Lanz RB (2010), Heck S (2009), Heck S (2009), Heck S (2009), Heck S (2009), Gunther JR (2008), Amazit L (2007), Mc Ilroy M (2006), Shao D (2004), Monroe DG (2003), Bai Y (2003), Bramlett KS (2001), Suen CS (1998), Chen H (1999), Rubio MF (2006), Han SJ (2016), Han SJ (2016), Li W (2015), Yi P (2015), Yi P (2017)	34
FOXG1	26	NR2F1	9	affinity chromatography technology	Li X (2015)	1
FOXC2	2	NR2F1	9	affinity chromatography technology	Li X (2015)	1
NR2F1	9	GTF2B	1	pull down	Ing NH (1992)	1
NR2F1	9	BCL11A	14	two hybrid, pull down, pull down, two hybrid, two hybrid	Avram D (2000), Avram D (2000), Chan CM (2013), Chan CM (2013), Chan CM (2013)	5
ESR1	0	PHB2	1	two hybrid, pull down, affinity chromatography technology, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology	Martini PG (2003), Kurtev V (2004), Kurtev V (2004), He B (2008), Martini PG (2000), Yoshimaru T (2013), Yoshimaru T (2013), Kim NH (2015)	8
AHR	3	NCOA2	2	affinity chromatography technology, pull down	Beischlag TV (2002), Watt K (2005)	2
FOXS1	2	NR2F1	9	affinity chromatography technology	Li X (2015)	1
NR2F1	9	CBX5	3	pull down	Marban C (2005)	1
TFAP4	3	NR2F1	9	affinity chromatography technology	Ku WC (2009)	1
ELAVL1	0	CD70	0	affinity chromatography technology	Abdelmohsen K (2009)	1
NSD1	25	NR2F1	9	two hybrid	Chan CM (2013)	1