PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RBL2	5	LIN54	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2009)	5
E2F4	0	RBL1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen CR (2002), Iavarone A (1999), Schmit F (2007), Moberg K (1996), Magae J (1996), Beijersbergen RL (1994), Ginsberg D (1994), Trimarchi JM (1998)	8
RB1	2	LIN54	1	pull down	Korenjak M (2004)	1
LIN9	3	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
E2F6	2	TFDP2	1	two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Cartwright P (1998), Rolland T (2014), Huttlin EL (2015), Trimarchi JM (1998), Yu H (2011), Huttlin EL (2017), Hauri S (2016)	8
E2F5	0	RBL2	5	biochemical, affinity chromatography technology, two hybrid	Hijmans EM (1995), Litovchick L (2007), Kong LJ (2006)	3
LIN9	3	RB1	2	affinity chromatography technology, pull down, pull down	Gagrica S (2004), Gagrica S (2004), Korenjak M (2004)	3
RBL1	1	E2F5	0	two hybrid	Hijmans EM (1995)	1
COMMD8	0	TFDP2	1	affinity chromatography technology	Huttlin EL (2017)	1
LIN54	1	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
L3MBTL2	1	E2F6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trojer P (2011), Trojer P (2011), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
E2F2	0	23429	0	two hybrid, affinity chromatography technology	Schlisio S (2002), Schlisio S (2002)	2
E2F2	0	E2F1	0	imaging technique	Chen TC (2014)	1
LIN9	3	RBL1	1	affinity chromatography technology	Schmit F (2007)	1
L3MBTL2	1	PCGF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trojer P (2011), Trojer P (2011), Gao Z (2012), Gao Z (2012), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
COMMD8	0	E2F6	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
RBL1	1	E2F1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dyson N (1993), Dyson N (1993), Moberg K (1996), Dhillon NK (2002), Su S (2013), Trimarchi JM (1998)	6
LIN54	1	E2F4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	3
23429	0	L3MBTL2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
LIN54	1	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	9
PCGF6	0	TFDP2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
LIN9	3	E2F4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Osterloh L (2007)	4
LIN54	1	LIN9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2017)	7
LIN37	0	E2F4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	3
PCGF6	0	E2F6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trimarchi JM (2001), Gao Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
23429	0	TFDP2	1	affinity chromatography technology	Huttlin EL (2017)	1
E2F4	0	TFDP2	1	x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zheng N (1999), Huttlin EL (2015), Trimarchi JM (1998), Huttlin EL (2017)	4
RBL1	1	E2F2	0	affinity chromatography technology	Moberg K (1996)	1
RBL1	1	TFDP2	1	affinity chromatography technology	Wu CL (1995)	1
RBL2	5	RBL1	1	affinity chromatography technology	Litovchick L (2007)	1
E2F3	0	RB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inoue Y (2007), Moberg K (1996), Ianari A (2009), Lees JA (1993)	4
E2F3	0	RBL1	1	affinity chromatography technology, affinity chromatography technology	von Eyss B (2011), Moberg K (1996)	2
LIN37	0	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
RBL2	5	E2F1	0	affinity chromatography technology	Dhillon NK (2002)	1
RBL2	5	LIN9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Osterloh L (2007)	5
RBL2	5	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
RB1	2	E2F4	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fajas L (2000), Iavarone A (1999), Moberg K (1996), Ezhevsky SA (1997), Ginsberg D (1994), Trimarchi JM (1998)	6
TFDP2	1	E2F2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
E2F4	0	23429	0	two hybrid	Schlisio S (2002)	1
RBL2	5	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	4
E2F6	2	23429	0	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trimarchi JM (2001), Trimarchi JM (2001), Trimarchi JM (2001), Trimarchi JM (2001), Trimarchi JM (2001), Schlisio S (2002), Gao Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	10
L3MBTL2	1	LIN54	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
RB1	2	TFDP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu CL (1995), Huttlin EL (2015), Huttlin EL (2017)	3
LIN54	1	RBL1	1	affinity chromatography technology	Schmit F (2007)	1
RB1	2	E2F2	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lee C (2002), Lee C (2002), Inoue Y (2007), Moberg K (1996), Lees JA (1993), Lees JA (1993)	6
E2F4	0	RBL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Iavarone A (1999), Litovchick L (2007), Schmit F (2007), Kong LJ (2006), Farkas T (2002), Osterloh L (2007), Yakovlev VA (2013), Martin N (2012), Martin N (2012)	9
LIN9	3	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	9
E2F3	0	23429	0	two hybrid, affinity chromatography technology	Schlisio S (2002), Schlisio S (2002)	2
L3MBTL2	1	RB1	2	affinity chromatography technology	Trojer P (2007)	1
L3MBTL2	1	TFDP2	1	affinity chromatography technology	Huttlin EL (2017)	1
PCGF6	0	23429	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Gao Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
E2F1	0	TFDP2	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu CL (1995), Cartwright P (1998), Huttlin EL (2015), Trimarchi JM (1998), Huttlin EL (2017)	5
TFDP2	1	E2F5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TFDP2	1	E2F3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LIN37	0	RBL1	1	affinity chromatography technology, affinity chromatography technology	Schmit F (2007), Schmit F (2007)	2
RB1	2	E2F1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Nicolas E (2001), Pardo PS (2002), Choubey D (1996), Fajas L (2000), Dyson N (1993), Dyson N (1993), Wu CL (1995), Taniura H (1998), Dai Y (2003), Fedele M (2006), Fedele M (2006), Brown VD (2002), De Blasio A (2005), Chau CM (2008), Dasgupta P (2004), Yang L (2011), Kruetzfeldt M (2005), Harbour JW (1999), Lee SJ (1998), Gao D (2009), Delston RB (2011), Gupta K (2000), Sdek P (2004), Flemington EK (1993), Chang YH (2012), Inoue Y (2007), Inoue Y (2007), Inoue Y (2007), Liu X (2006), Moberg K (1996), Knudsen ES (1996), Brown VD (1999), Brown VD (1999), Whitaker LL (1998), Whitaker LL (1998), Hagemeier C (1993), Bhat UG (1999), Xiao B (2003), Xiao B (2003), Vidal M (1996), Markham D (2006), Markham D (2006), Ianari A (2009), Ianari A (2009), Dhillon NK (2002), Knudsen ES (1997), Knudsen ES (1997), Gery S (2004), Gery S (2004), Kashuba E (2008), Kashuba E (2008), Pearson A (1997), Ginsberg D (1994), Welch PJ (1995), Wang J (2009), Aoki I (2012), Trimarchi JM (1998), Kumari A (2015), Gamell C (2017), Chen TT (2000), Chen TT (2000), Chen TT (2000), Chen TT (2000)	63