PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBQLN4	2	TFF1	0	two hybrid	Lim J (2006)	1
TFF1	0	ZNF250	2	two hybrid	Rolland T (2014)	1
ATM	9	TFF1	0	two hybrid	Arroyo R (2015)	1
AKT1	1	ESR1	0	enzymatic study	Campbell RA (2001)	1
FCRL4	2	TFF1	0	pull down	Ramani SR (2012)	1
FGFR2	6	TFF1	0	two hybrid	Arroyo R (2015)	1
XRCC3	1	TFF1	0	two hybrid	Arroyo R (2015)	1
ESR2	1	TFF1	0	two hybrid	Arroyo R (2015)	1
NCOA3	3	TFF1	0	genetic interference	Yi P (2008)	1
BTN3A1	3	TFF1	0	pull down	Ramani SR (2012)	1
CAVIN1	0	TFF1	0	affinity chromatography technology	Jansa P (1998)	1
ESR1	0	TFF1	0	genetic interference	Yi P (2008)	1
AKT1	1	TFF1	0	two hybrid	Arroyo R (2015)	1
TFF1	0	TFF1	0	pull down	Chadwick MP (1997)	1
ESR2	1	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, biochemical	Ogawa S (1998), Ogawa S (1998), Ogawa S (1998), Poelzl G (2000), Rossi V (2009), Monroe DG (2003), Nassa G (2011)	7
ESR1	0	PRKCZ	5	affinity chromatography technology	Yi P (2008)	1
RAD51	3	ESR1	0	affinity chromatography technology, affinity chromatography technology	Jung YS (2014), Jung YS (2014)	2
TSG101	1	TFF1	0	two hybrid	Arroyo R (2015)	1
PRKCZ	5	TFF1	0	genetic interference	Yi P (2008)	1
BTNL8	2	TFF1	0	pull down	Ramani SR (2012)	1
RAD51	3	XRCC3	1	imaging technique	Tarsounas M (2004)	1
NCOA3	3	ESR1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Wong CW (2001), Tikkanen MK (2000), Tikkanen MK (2000), Feng Q (2006), Long X (2008), Long X (2008), Dutertre M (2003), Jaber BM (2004), Torchia J (1997), Torchia J (1997), Karmakar S (2010), Takeshita A (1997), Zhao HH (2001), Wu RC (2004), Lanz RB (2010), Heck S (2009), Heck S (2009), Heck S (2009), Heck S (2009), Gunther JR (2008), Amazit L (2007), Mc Ilroy M (2006), Shao D (2004), Monroe DG (2003), Bai Y (2003), Bramlett KS (2001), Suen CS (1998), Chen H (1999), Rubio MF (2006), Han SJ (2016), Han SJ (2016), Li W (2015), Yi P (2015), Yi P (2017)	34
NCOA3	3	PRKCZ	5	affinity chromatography technology, enzymatic study	Yi P (2008), Yi P (2008)	2
NCOA3	3	ESR2	1	pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe, unspecified method, two hybrid, affinity chromatography technology	Wong CW (2001), Leo C (2000), Iannone MA (2001), Mc Ilroy M (2006), Bai Y (2003), Bramlett KS (2001), Suen CS (1998), Nassa G (2011)	8
CD300LD	0	TFF1	0	pull down	Ramani SR (2012)	1
RAD51	3	TFF1	0	two hybrid	Arroyo R (2015)	1
APC	5	TFF1	0	two hybrid	Arroyo R (2015)	1
TFF1	0	UBQLN1	1	two hybrid	Rual JF (2005)	1
RAD51	3	ATM	9	affinity chromatography technology, affinity chromatography technology	Chen G (1999), Chen G (1999)	2
UBQLN4	2	UBQLN1	1	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Havugimana PC (2012), Lee DY (2013), Lee DY (2013)	4
PRKCZ	5	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Doornbos RP (1999), Wang J (2008), Wang J (2008), Joshi J (2008), Joshi J (2008)	5
SIGLEC8	2	TFF1	0	pull down	Ramani SR (2012)	1