PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TGFB1	2	THRSP	0	two hybrid	Arroyo R (2015)	1
TGFB1	2	NSD3	6	two hybrid	Arroyo R (2015)	1
THBS1	6	COL2A1	9	pull down	Galvin NJ (1987)	1
FBXO6	0	LAMC1	5	affinity chromatography technology	Liu B (2012)	1
TGFB1	2	FKBP1A	0	two hybrid, two hybrid	Cheng SY (2002), Li Y (2013)	2
TGFB1	2	MTA3	3	two hybrid	Arroyo R (2015)	1
TGFB1	2	DCN	0	pull down, pull down, pull down	Hildebrand A (1994), Schoenherr E (1998), Takeuchi Y (1994)	3
TGFB1	2	KLK5	1	two hybrid	Arroyo R (2015)	1
LAMTOR5	1	TGFB1	2	two hybrid	Fan W (2013)	1
TGFBR2	0	TGFBR3	1	affinity chromatography technology	Lopez-Casillas F (1994)	1
TGFB1	2	PDLIM2	0	two hybrid	Arroyo R (2015)	1
TGFB1	2	PRSS50	0	two hybrid	Arroyo R (2015)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
TGFB1	2	GREB1	8	two hybrid	Arroyo R (2015)	1
LRRC32	1	TGFB1	2	affinity chromatography technology	Huttlin EL (2017)	1
TGFB1	2	SCGB3A1	0	two hybrid	Arroyo R (2015)	1
TGFB1	2	DIRAS3	0	two hybrid	Arroyo R (2015)	1
TGFB1	2	COL2A1	9	pull down	Zhu Y (1999)	1
CCDC33	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TGFB1	2	NMT2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KLK9	1	APP	1	pull down	Olah J (2011)	1
NMT2	2	APP	1	pull down	Olah J (2011)	1
FBXO6	0	LAMB1	10	affinity chromatography technology	Liu B (2012)	1
TGFB1	2	CCL5	1	two hybrid	Arroyo R (2015)	1
FKBP1A	0	APP	1	pull down	Olah J (2011)	1
ENG	5	TGFB1	2	affinity chromatography technology	Cheifetz S (1992)	1
TRIM25	5	TGFBR2	0	affinity chromatography technology	Choudhury NR (2017)	1
EIF1AX	0	APP	1	pull down	Olah J (2011)	1
FNTA	0	TGFBR1	2	two hybrid, pull down, enzymatic study	Kawabata M (1995), Kawabata M (1995), Kawabata M (1995)	3
TGFB1	2	FCN1	2	biochemical	Ichijo H (1993)	1
EPS15	1	TGFB1	2	affinity chromatography technology, imaging technique, affinity chromatography technology	Parachoniak CA (2009), Parachoniak CA (2009), Parachoniak CA (2009)	3
TGFB1	2	APP	1	imaging technique	Chen TC (2014)	1
LTBP1	4	TGFB1	2	affinity chromatography technology, pull down	Saharinen J (2000), Saharinen J (2000)	2
TGFB1	2	NMT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TGFB1	2	BCAS3	4	two hybrid	Arroyo R (2015)	1
VASN	2	TGFB1	2	pull down	Ikeda Y (2004)	1
TGFB1	2	C4orf48	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TGFBR2	0	DAXX	5	two hybrid	Perlman R (2001)	1
MEOX2	2	RMND5A	0	two hybrid	Rolland T (2014)	1
TGFBR2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
ANGPTL4	2	NMT1	4	affinity chromatography technology	Huttlin EL (2017)	1
MMP9	1	TGFB1	2	enzymatic study, imaging technique	Yu Q (2000), Chen TC (2014)	2
FBXO6	0	NRROS	7	affinity chromatography technology	Liu B (2012)	1
MMP2	2	COL2A1	9	affinity chromatography technology	Huttlin EL (2017)	1
TGFB1	2	KLK9	1	two hybrid	Arroyo R (2015)	1
TGFBR3	1	TGFB1	2	affinity chromatography technology	Lopez-Casillas F (1994)	1
ACVRL1	1	TGFB1	2	affinity chromatography technology, affinity chromatography technology	Oh SP (2000), Attisano L (1993)	2
TGFB1	2	HOXC6	0	two hybrid	Arroyo R (2015)	1
TGFB1	2	LAMC1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MMP2	2	TGFB1	2	enzymatic study, imaging technique	Yu Q (2000), Chen TC (2014)	2
TRIM25	5	TGFBR1	2	affinity chromatography technology	Choudhury NR (2017)	1
VTN	1	APP	1	pull down	Olah J (2011)	1
TGFB1	2	CST6	1	two hybrid	Arroyo R (2015)	1
LAMC1	5	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
RMND5A	0	APP	1	pull down	Olah J (2011)	1
MEOX2	2	TGFB1	2	two hybrid	Rolland T (2014)	1
LAMC1	5	LAMB1	10	x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology	McKee KK (2007), McKee KK (2007), McKee KK (2007), McKee KK (2007), McKee KK (2007), McKee KK (2007)	6
TGFBR1	2	TGFB1	2	affinity chromatography technology, affinity chromatography technology, pull down	Ebner R (1993), Oh SP (2000), Wakahara K (2005)	3
TGFB1	2	KLK7	0	two hybrid	Arroyo R (2015)	1
TGFBR2	0	TGFB1	2	affinity chromatography technology, affinity chromatography technology	Rotzer D (2001), Attisano L (1993)	2
MEOX2	2	LAMTOR5	1	two hybrid	Rolland T (2014)	1
TGFB1	2	FMOD	2	pull down	Hildebrand A (1994)	1
DEFA1	0	LAMB1	10	affinity chromatography technology	Huttlin EL (2017)	1
TGFBR1	2	TGFBR2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Kawabata M (1995), Razani B (2001), Yan X (2011), Yan X (2009), Kim SI (2009), Kim SI (2009), Datta PK (2000), Perlman R (2001), Cho W (2015)	9
TRIM25	5	YWHAE	0	affinity chromatography technology	Choudhury NR (2017)	1
PZP	3	TGFB1	2	pull down	Philip A (1994)	1
PLA2G10	0	TGFB1	2	affinity chromatography technology	Huttlin EL (2017)	1
TGFB1	2	ERP44	1	affinity chromatography technology	Huttlin EL (2017)	1
SLC35G2	1	TGFB1	2	affinity chromatography technology	Huttlin EL (2015)	1
HOXC6	0	APP	1	pull down	Olah J (2011)	1
FBXO6	0	LTBP1	4	affinity chromatography technology	Liu B (2012)	1
DEFA1	0	TGFB1	2	affinity chromatography technology	Huttlin EL (2017)	1
THBS1	6	MMP2	2	two hybrid, affinity chromatography technology	Bein K (2000), Bein K (2000)	2
KLK7	0	APP	1	pull down	Olah J (2011)	1
DAXX	5	NSD3	6	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
TRIM25	5	FEM1B	1	affinity chromatography technology	Choudhury NR (2017)	1
FBXO6	0	YWHAE	0	affinity chromatography technology	Liu B (2012)	1
TGFB1	2	BLID	0	two hybrid	Arroyo R (2015)	1
VTN	1	TGFB1	2	pull down	Schoppet M (2002)	1
TGFB1	2	ANGPTL4	2	two hybrid	Arroyo R (2015)	1
ACVRL1	1	FKBP1A	0	two hybrid	Lee NY (2009)	1
TGFB1	2	RMND5A	0	affinity chromatography technology	Huttlin EL (2015)	1
TGFB1	2	SNAI1	1	two hybrid	Arroyo R (2015)	1
ANGPTL4	2	NMT2	2	affinity chromatography technology	Huttlin EL (2017)	1
TGFB1	2	FNTA	0	two hybrid	Wang T (1996)	1
TGFBR1	2	ENG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Barbara NP (1999), Blanco FJ (2008), Blanco FJ (2008), Blanco FJ (2005)	7
FBXO6	0	TGFB1	2	affinity chromatography technology	Liu B (2012)	1
TGFB1	2	ST14	2	two hybrid	Arroyo R (2015)	1
MMP2	2	PZP	3	pull down	Arbelaez LF (1997)	1
MMP9	1	THBS1	6	affinity chromatography technology	Bein K (2000)	1
TGFB1	2	CCDC33	3	two hybrid	Rolland T (2014)	1
TGFB1	2	FEM1B	1	affinity chromatography technology	Huttlin EL (2015)	1
YWHAE	0	TGFB1	2	pull down, affinity chromatography technology	McGonigle S (2001), McGonigle S (2001)	2
TGFBR2	0	ENG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Barbara NP (1999), Barbara NP (1999), Blanco FJ (2005)	6
TRIM25	5	TGFB1	2	affinity chromatography technology	Choudhury NR (2017)	1
APP	1	BGN	0	pull down	Snow AD (1995)	1
TGFB1	2	EIF1AX	0	affinity chromatography technology	Huttlin EL (2015)	1
MMP9	1	COL2A1	9	affinity chromatography technology	Huttlin EL (2017)	1
ACVRL1	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Attisano L (1993), Attisano L (1993)	2
FKBP1A	0	TGFBR1	2	two hybrid, two hybrid, affinity chromatography technology	Wang T (1994), Liu F (1995), Wang T (1994)	3
ENG	5	ACVRL1	1	affinity chromatography technology, affinity chromatography technology	Blanco FJ (2005), Blanco FJ (2005)	2
TGFB1	2	THBS1	6	biochemical	Murphy-Ullrich JE (1992)	1
NRROS	7	TGFB1	2	affinity chromatography technology	Huttlin EL (2017)	1
TGFB1	2	DAXX	5	imaging technique	Chen TC (2014)	1
TRIM25	5	PSMC3IP	0	affinity chromatography technology	Choudhury NR (2017)	1
TGFB1	2	PSMC3IP	0	two hybrid	Arroyo R (2015)	1
TRIM25	5	GREB1	8	affinity chromatography technology	Choudhury NR (2017)	1
TGFB1	2	LAMB1	10	two hybrid	Bandyopadhyay S (2010)	1
TGFB1	2	UBR1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TGFB1	2	AGR3	2	two hybrid	Arroyo R (2015)	1
DEFA1	0	TGFBR3	1	affinity chromatography technology	Huttlin EL (2017)	1
TGFB1	2	BGN	0	pull down	Hildebrand A (1994)	1