PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ENG	5	ACVR2B	0	affinity chromatography technology	Barbara NP (1999)	1
SMURF2	3	TRAF4	1	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study	Colland F (2004), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013)	8
TGFBR2	0	ACVR1	4	two hybrid	Kawabata M (1995)	1
TGFBR2	0	DENND6A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD7	1	CTNNB1	30	affinity chromatography technology, imaging technique, affinity chromatography technology	Edlund S (2005), Edlund S (2005), Tang Y (2008)	3
PEG10	2	ACVR2A	0	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
IQGAP1	1	CTNNB1	30	pull down	Briggs MW (2002)	1
TGFBR2	0	FAM171A2	1	affinity chromatography technology	Huttlin EL (2015)	1
ACVR1B	1	ACVR1	4	affinity chromatography technology, affinity chromatography technology	De Winter JP (1996), Huttlin EL (2015)	2
TGFBR2	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Krymskaya VP (1997), Huttlin EL (2015), Huttlin EL (2017)	3
SMAD7	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Asano Y (2004), Koinuma D (2003), Kavsak P (2000), Hayashi H (1997), Hayashi H (1997), Datta PK (2000), Wicks SJ (2005), Lallemand F (2005), Seong HA (2007), Yan X (2011), Cai Y (2012), Cai Y (2012), Seo SR (2004), Zhu L (2012), Zhu L (2012), Nakao A (1997), Yan X (2009), Kamiya Y (2010), Suzuki C (2002), Hsu HY (2014)	21
IQGAP1	1	DAB2	1	affinity chromatography technology	Hein MY (2015)	1
CCNB1	3	CDC6	0	enzymatic study	Jiang W (1999)	1
ACVR1	4	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
ACVR2B	0	ACVR1B	1	biochemical, affinity chromatography technology	Attisano L (1996), De Winter JP (1996)	2
STRAP	2	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Datta PK (1998), Datta PK (2000)	2
TGFBR1	2	PIK3R1	6	affinity chromatography technology	Krymskaya VP (1997)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
TYK2	1	JAK1	6	affinity chromatography technology	Domanski P (1995)	1
SMURF2	3	DAB2	1	two hybrid	Colland F (2004)	1
CBL	7	PIK3R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Lin H (2001), Hartley D (1995), Feshchenko EA (2004), Alcazar I (2009), Brehme M (2009), Brehme M (2009), Grossmann A (2015)	7
TGFBR2	0	PLEKHH3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BMPR1A	5	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
TGFBR2	0	JAK1	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RELT	3	PIK3R3	0	affinity chromatography technology	Huttlin EL (2015)	1
HSP90AA1	7	ERBB2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu W (2001), Jeong JH (2008), Mollapour M (2010), Citri A (2002), Jung Y (2007), Suzuki T (2011), Tsutsumi S (2012), Taipale M (2012), Bali P (2005), Woodford MR (2016), Yan YY (2011), Yan YY (2011)	12
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
OXSR1	2	APP	1	pull down	Olah J (2011)	1
OCLN	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Barrios-Rodiles M (2005), Barrios-Rodiles M (2005)	2
NDFIP1	0	SMURF1	4	affinity chromatography technology	Wang Y (2012)	1
SMAD7	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Asano Y (2004), Kavsak P (2000), Lee YS (2008), Komuro A (2004), Chong PA (2010), Chong PA (2010), Chong PA (2010), Cai Y (2012), Cai Y (2012), Chong PA (2006), Al-Salihi MA (2012), Ogunjimi AA (2005), Aragon E (2012), Aragon E (2012), Colland F (2004), Zhang L (2013), Chandhoke AS (2015), Iyengar PV (2015), Elkouris M (2016)	19
TGFBR2	0	TGFBR3	1	affinity chromatography technology	Lopez-Casillas F (1994)	1
TRIM25	5	MYADM	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
CBL	7	PIK3CB	2	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Momose H (2003)	2
TGFBR2	0	CD320	1	affinity chromatography technology	Huttlin EL (2015)	1
CDC42	3	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
CTNNB1	30	TGFBR2	0	affinity chromatography technology	Tian YC (2002)	1
TGFBR2	0	FMN2	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TGFBR2	0	PIK3R3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
PAK1	2	ERBB2	6	affinity chromatography technology	Adam L (1998)	1
HSP90AA1	7	ACVR1B	1	affinity chromatography technology	Taipale M (2012)	1
TRIM25	5	CTNNB1	30	affinity chromatography technology	Choudhury NR (2017)	1
PAK1	2	HSP90AA1	7	two hybrid	Bandyopadhyay S (2010)	1
PPP1R16B	2	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
TRIM25	5	CTDNEP1	1	affinity chromatography technology	Choudhury NR (2017)	1
TGFBR2	0	ERBB2	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TGFBR2	0	WDR44	0	affinity chromatography technology	Huttlin EL (2015)	1
MAP3K7	2	HSP90AA1	7	affinity chromatography technology	Liu XY (2008)	1
TRIM25	5	PTPRS	15	affinity chromatography technology	Choudhury NR (2017)	1
TGFBR2	0	CBL	7	pull down, affinity chromatography technology, enzymatic study	Zuo W (2013), Zuo W (2013), Zuo W (2013)	3
PAK1	2	APP	1	pull down	Olah J (2011)	1
TGFBR2	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Kim SI (2009), Kim SI (2009)	2
SMAD7	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Asano Y (2004), Yamaguchi T (2006), Komuro A (2004), Ebisawa T (2001), Ebisawa T (2001), Al-Salihi MA (2012), Suzuki C (2002), Aragon E (2012), Aragon E (2012), Tajima Y (2003), Fei C (2013), Fei C (2014), Wan L (2011), Elkouris M (2016)	14
BMPR1A	5	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
HSP90AA1	7	FBXO34	0	affinity chromatography technology	Taipale M (2012)	1
DAB2	1	TGFBR1	2	affinity chromatography technology	Hocevar BA (2001)	1
ERBB2	6	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, far western blotting	Schroeder JA (2002), Bonvini P (2001), Schroeder JA (2002), Schroeder JA (2002), Kanai Y (1995), Kanai Y (1995)	6
TRIM25	5	CBL	7	affinity chromatography technology	Choudhury NR (2017)	1
HSP90AA1	7	SPSB1	3	affinity chromatography technology	Taipale M (2012)	1
TRIM25	5	PPP1R16B	2	affinity chromatography technology	Choudhury NR (2017)	1
TGFBR2	0	PTPRS	15	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CLU	1	PTPRS	15	affinity chromatography technology	Huttlin EL (2017)	1
DAB2	1	AP2B1	3	affinity chromatography technology	Mulkearns EE (2012)	1
DAB2	1	TGFBR2	0	affinity chromatography technology	Hocevar BA (2001)	1
TRIM25	5	BMPR1A	5	affinity chromatography technology	Choudhury NR (2017)	1
TGFBR1	2	AP2B1	3	affinity chromatography technology	Yao D (2002)	1
TGFBR2	0	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhang L (2013)	2
TGFBR2	0	MFAP3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ENG	5	TGFB1	2	affinity chromatography technology	Cheifetz S (1992)	1
SMAD7	1	TGFBR2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Nakao A (1997), Hsu HY (2014)	3
TRIM25	5	TGFBR2	0	affinity chromatography technology	Choudhury NR (2017)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
HSP90AA1	7	ACVR2B	0	affinity chromatography technology	Taipale M (2012)	1
TGFBR2	0	RELT	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CTNNB1	30	SMURF1	4	affinity chromatography technology, pull down	Boonanantanasarn K (2015), Boonanantanasarn K (2015)	2
TGFBR2	0	PTPRF	9	affinity chromatography technology	Huttlin EL (2015)	1
ACVR1B	1	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
PPP1R16B	2	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
TGFB1	2	APP	1	imaging technique	Chen TC (2014)	1
TGFBR2	0	AP2B1	3	affinity chromatography technology, two hybrid	Yao D (2002), Yao D (2002)	2
KCNK18	0	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
TGFBR2	0	CCNB1	3	pull down	Liu JH (1999)	1
CCNB1	3	CCNB2	3	biochemical	Wan C (2015)	1
TGFBR1	2	TSC22D1	1	two hybrid, affinity chromatography technology, pull down	Yan X (2011), Yan X (2011), Yan X (2011)	3
ENG	5	TGFB3	0	affinity chromatography technology	Cheifetz S (1992)	1
TGFBR2	0	LRP10	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO34	0	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
PEG10	2	ACVR2B	0	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
STRAP	2	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Datta PK (1998), Datta PK (2000)	2
TGFBR2	0	SH3KBP1	1	affinity chromatography technology	Yakymovych I (2015)	1
TGFBR2	0	DAXX	5	two hybrid	Perlman R (2001)	1
TGFBR2	0	ACVR2A	0	affinity chromatography technology	Huttlin EL (2015)	1
CDC42	3	ARHGEF6	0	affinity chromatography technology, imaging technique	Feng Q (2004), Chen TC (2014)	2
TGFBR2	0	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TGFBR2	0	ACVR2B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PIK3R2	3	IQGAP1	1	affinity chromatography technology	Brehme M (2009)	1
SMAD7	1	MAP3K7	2	affinity chromatography technology	Edlund S (2003)	1
OXSR1	2	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
TRIM25	5	TGFBRAP1	2	affinity chromatography technology	Choudhury NR (2017)	1
TGFBR2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TGFBR2	0	LSR	0	affinity chromatography technology	Huttlin EL (2015)	1
TGFBR2	0	RAB6A	0	affinity chromatography technology	Huttlin EL (2015)	1
CDC42	3	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
TGFBR2	0	TYK2	1	affinity chromatography technology	Huttlin EL (2015)	1
PAK1	2	TGFBR2	0	pull down, affinity chromatography technology	Barrios-Rodiles M (2005), Barrios-Rodiles M (2005)	2
TGFBR1	2	TGFBRAP1	2	affinity chromatography technology	Wurthner JU (2001)	1
SMAD7	1	CBL	7	affinity chromatography technology, affinity chromatography technology, pull down	Ha Thi HT (2015), Ha Thi HT (2015), Ha Thi HT (2015)	3
PAK1	2	CDC42	3	pull down, pull down, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Seoh ML (2003), Zhang B (1998), Bandyopadhyay S (2010), Mott HR (1999), Owen D (2000), Morreale A (2000), Wells CD (2006), Marivin A (2013), Varjosalo M (2013), Shen Y (2008), Gonzalez-Martinez D (2004)	11
TRIM25	5	PTPRF	9	affinity chromatography technology	Choudhury NR (2017)	1
DAXX	5	RASSF1	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, affinity chromatography technology, unspecified method	Song MS (2008), Song MS (2008), Kitagawa D (2006), Kitagawa D (2006), Giovinazzi S (2012), Giovinazzi S (2012), Escobar-Cabrera E (2010), Zhang H (2013), Li Z (2017)	9
SMAD7	1	TSC22D1	1	affinity chromatography technology, affinity chromatography technology	Yan X (2011), Yan X (2011)	2
TGFBR1	2	PIK3R2	3	affinity chromatography technology	Krymskaya VP (1997)	1
SH3KBP1	1	DAB2	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Havrylov S (2009), Kowanetz K (2003), Kowanetz K (2003)	3
TYK2	1	TRAF4	1	two hybrid	Rolland T (2014)	1
CLU	1	PTPRF	9	affinity chromatography technology	Huttlin EL (2017)	1
PEG10	2	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
PIK3R1	6	SH3KBP1	1	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Gout I (2000), Tossidou I (2010), Borthwick EB (2004), Borthwick EB (2004)	4
HSP90AA1	7	BMPR1A	5	affinity chromatography technology	Taipale M (2012)	1
ACVR1	4	CD320	1	affinity chromatography technology	Huttlin EL (2017)	1
PIK3R2	3	PIK3CB	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
TGFBR3	1	TGFB1	2	affinity chromatography technology	Lopez-Casillas F (1994)	1
CBL	7	TRAF4	1	two hybrid	Woodsmith J (2012)	1
CDC42	3	CBL	7	affinity chromatography technology, pull down, affinity chromatography technology	Wu WJ (2003), Wu WJ (2003), Simmons A (2005)	3
STRAP	2	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Datta PK (2000), Datta PK (2000), Datta PK (2000), Seong HA (2007)	4
ARHGEF6	0	PAK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Varjosalo M (2013), Huttlin EL (2017)	3
TGFBR1	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Yakymovych I (2015), Yakymovych I (2015)	2
PDGFRA	3	CLU	1	affinity chromatography technology	Hein MY (2015)	1
PIK3R2	3	APP	1	pull down	Olah J (2011)	1
IQGAP1	1	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Liu C (2013), Liu C (2013)	2
ACVR1B	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Yamaguchi T (2006), Murakami G (2003)	2
TRIM25	5	TGFBR1	2	affinity chromatography technology	Choudhury NR (2017)	1
CBL	7	ERBB2	6	pull down, affinity chromatography technology	Zhou P (2003), Bisaro B (2016)	2
TGFBR1	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koinuma D (2003), Ebisawa T (2001), Murakami G (2003)	3
ACVR1	4	BMPR1A	5	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Lavery K (2008), Lavery K (2008), Huttlin EL (2015), Huttlin EL (2017)	4
PEG10	2	ACVR1B	1	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
TRIM25	5	CD320	1	affinity chromatography technology	Choudhury NR (2017)	1
ACVR1B	1	SMAD7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu X (2002), Yamaguchi T (2006), Yamaguchi T (2006), Kamiya Y (2010)	4
PIK3R3	0	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
SNX6	1	TGFBR1	2	affinity chromatography technology	Parks WT (2001)	1
NRP1	2	TGFBR3	1	pull down	Glinka Y (2011)	1
SMURF2	3	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Hsu HY (2014)	2
SMURF2	3	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Yan X (2011), Cai Y (2012), Cai Y (2012), Zhang L (2013), Chandhoke AS (2015), Hsu HY (2014)	7
RELT	3	OXSR1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TERT	7	TGFBR2	0	two hybrid	Wang W (2013)	1
TRAF6	0	APP	1	pull down	Olah J (2011)	1
TGFBR2	0	TGFB2	2	affinity chromatography technology	Rotzer D (2001)	1
TGFBR1	2	TGFB1	2	affinity chromatography technology, affinity chromatography technology, pull down	Ebner R (1993), Oh SP (2000), Wakahara K (2005)	3
TGFBR2	0	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
FBXO34	0	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
SMAD7	1	ACVR2B	0	affinity chromatography technology	Kamiya Y (2010)	1
TGFBR2	0	TGFB1	2	affinity chromatography technology, affinity chromatography technology	Rotzer D (2001), Attisano L (1993)	2
TGFBR2	0	ACVR1B	1	affinity chromatography technology	Huttlin EL (2015)	1
SMURF1	4	PDGFRA	3	enzymatic study	Andrews PS (2010)	1
OXSR1	2	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
TRIM25	5	IQGAP1	1	affinity chromatography technology	Choudhury NR (2017)	1
TGFBR2	0	MYADM	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ACVR1	4	ACVR2A	0	affinity chromatography technology, affinity chromatography technology	Attisano L (1993), Attisano L (1993)	2
ERBB2	6	PIK3R3	0	unspecified method	Jones RB (2006)	1
TRIM25	5	AP2B1	3	affinity chromatography technology	Choudhury NR (2017)	1
TGFBR1	2	TGFBR2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Kawabata M (1995), Razani B (2001), Yan X (2011), Yan X (2009), Kim SI (2009), Kim SI (2009), Datta PK (2000), Perlman R (2001), Cho W (2015)	9
TYK2	1	CBL	7	affinity chromatography technology	Uddin S (1996)	1
SMURF1	4	JAK1	6	affinity chromatography technology	Xie Y (2013)	1
ARHGEF6	0	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
PIK3R2	3	PIK3R3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
TGFBR2	0	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yamashita M (2008), Yamashita M (2008), Yamashita M (2008), Cao Q (2016)	4
TGFBR2	0	EHD4	1	affinity chromatography technology	Huttlin EL (2015)	1
SH3KBP1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Petrelli A (2002), Soubeyran P (2002), Soubeyran P (2002), Szymkiewicz I (2002), Borinstein SC (2000), Schmidt MH (2006), Schmidt MH (2004), Schmidt MH (2004), Verdier F (2002), Verdier F (2002), Feshchenko EA (2004), Chandra V (2010), Niiro H (2012), Feng L (2011), Havrylov S (2009), Zhang J (2009), Zhang J (2009), Ababou A (2009), Le Bras S (2007), Jozic D (2005), Kowanetz K (2004), Kowanetz K (2003), Kowanetz K (2003), Tibaldi EV (2003), Tibaldi EV (2003), Take H (2000), Take H (2000), Schroeder B (2012), Schroeder B (2012), Peruzzi G (2007), Selbach M (2006), Sato S (2013), Taipale M (2014), Taipale M (2014), Diesenberg K (2015), Petrelli A (2002), Huttlin EL (2017)	39
CLU	1	TGFBR2	0	two hybrid, pull down, affinity chromatography technology	Reddy KB (1996), Reddy KB (1996), Reddy KB (1996)	3
TGFBR2	0	RAB6B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTPRS	15	PTPRF	9	bioid	St-Denis N (2016)	1
HSP90AA1	7	PKN2	6	affinity chromatography technology	Taipale M (2012)	1
ACVR1	4	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
PTPRF	9	CTNNB1	30	affinity chromatography technology, pull down	Bonvini P (2001), Aicher B (1997)	2
TRAF6	0	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique	Sorrentino A (2008), Yamashita M (2008), Yamashita M (2008), Yamashita M (2008), Zhang J (2014), Cao Q (2016), Sundar R (2015), Sundar R (2015), Sundar R (2015)	9
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
DAXX	5	TERT	7	affinity chromatography technology	Tang M (2015)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
CBL	7	PDGFRA	3	affinity chromatography technology, pull down	Bonita DP (1997), Bonita DP (1997)	2
TGFBR2	0	SPSB1	3	affinity chromatography technology, affinity chromatography technology	Liu S (2015), Liu S (2015)	2
ACVR2A	0	DAXX	5	two hybrid	Perlman R (2001)	1
TGFBR2	0	PIK3CB	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RASSF1	3	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology	Lee MG (2016), Lee MG (2016), Lee MG (2016)	3
TRAF6	0	TRAF4	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Takeshita F (2005), Takeshita F (2005), Chen TC (2014)	3
SMAD7	1	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Kamiya Y (2010)	2
TGFBR2	0	CTDNEP1	1	affinity chromatography technology	Huttlin EL (2015)	1
RAB6B	2	SBF1	15	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	TERT	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Holt SE (1999), Lee JH (2010), Lee JH (2010), Forsythe HL (2001)	6
ENG	5	ACVR1	4	affinity chromatography technology	Barbara NP (1999)	1
ENG	5	ACVR2A	0	affinity chromatography technology	Barbara NP (1999)	1
PAK1	2	SH3KBP1	1	affinity chromatography technology	Schmidt MH (2006)	1
HSP90AA1	7	TGFBR1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wrighton KH (2008), Wrighton KH (2008), Wrighton KH (2008), Zhang K (2012), Zhang K (2012), Antonov AS (2012)	6
SMURF1	4	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Ebisawa T (2001), Johansson E (2016)	2
TGFBR2	0	NDFIP1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCNK18	0	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
TGFB3	0	TGFBR2	0	pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	De Crescenzo G (2003), Hart PJ (2002), Barbara NP (1999), Rotzer D (2001)	4
PDGFRA	3	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCNB2	3	TGFBR2	0	pull down, pull down	Liu JH (1999), Liu JH (1999)	2
HSP90AA1	7	JAK1	6	affinity chromatography technology	Taipale M (2012)	1
ARHGEF6	0	CBL	7	affinity chromatography technology, affinity chromatography technology	Kortuem F (2015), Kortuem F (2015)	2
PDGFRA	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, imaging technique	Zhu MJ (2007), Zhu MJ (2007), Chen TC (2014)	3
FGFR1	2	CTNNB1	30	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), Boscher C (2008), Boscher C (2008)	3
FGFR1	2	PIK3R2	3	two hybrid	Hu Y (2004)	1
SNX6	1	ACVR2B	0	affinity chromatography technology	Parks WT (2001)	1
PIK3CB	2	PIK3R1	6	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique	Hu P (1994), Havugimana PC (2012), Sun M (2010), Wan C (2015), Hein MY (2015), Chen TC (2014)	6
HSP90AA1	7	FGFR1	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Vecchione A (2007)	2
ACVR1B	1	ACVR2A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lebrun JJ (1999), De Winter JP (1996), Yamakawa N (2002)	3
PIK3R2	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
TGFBR2	0	TGFBRAP1	2	affinity chromatography technology	Wurthner JU (2001)	1
CLU	1	TGFBR1	2	two hybrid, pull down, affinity chromatography technology	Reddy KB (1996), Reddy KB (1996), Reddy KB (1996)	3
ERBB2	6	AP2B1	3	affinity chromatography technology	Giri DK (2005)	1
TGFBR2	0	MARCH7	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARHGEF6	0	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
GOPC	5	PKN2	6	affinity chromatography technology	Huttlin EL (2017)	1
TRAF4	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Wang A (2014), Wang A (2014)	2
CTNNB1	30	APP	1	pull down	Olah J (2011)	1
RASSF1	3	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RAB6B	2	RAB6A	0	affinity chromatography technology	Huttlin EL (2017)	1
TGFBR2	0	PIK3R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Krymskaya VP (1997), Huttlin EL (2015), Huttlin EL (2017)	3
CTNNB1	30	CBL	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Chitalia V (2013), Chitalia V (2013), Chitalia V (2013), Shivanna S (2015)	4
CBL	7	IQGAP1	1	affinity chromatography technology	Brehme M (2009)	1
NRP1	2	TGFBR1	2	affinity chromatography technology, pull down, affinity chromatography technology	Cao Y (2010), Glinka Y (2011), Glinka Y (2011)	3
TGFBR1	2	ENG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Barbara NP (1999), Blanco FJ (2008), Blanco FJ (2008), Blanco FJ (2005)	7
TGFBR2	0	FGFR1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TGFBR2	0	PKN3	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP3K7	2	NDFIP1	0	affinity chromatography technology, affinity chromatography technology	Kathania M (2015), Kathania M (2015)	2
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
ERBB2	6	PIK3R2	3	pull down, unspecified method	Gout I (1992), Jones RB (2006)	2
TGFB2	2	APP	1	imaging technique	Chen TC (2014)	1
ACVR1	4	TGFBRAP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TGFBR2	0	EIF3I	0	affinity chromatography technology, affinity chromatography technology	Choy L (1998), Choy L (1998)	2
PDGFRA	3	TGFBR2	0	two hybrid	Wang J (2011)	1
TGFBR2	0	PKN2	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APP	1	CLU	1	pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology	Hammad SM (1997), Ghiso J (1993), Chen P (2013), Chen P (2013)	4
FGFR1	2	PIK3R1	6	imaging technique, two hybrid, pull down	Chen TC (2014), Hu Y (2004), Shi E (1993)	3
TGFBR3	1	FGFR1	2	affinity chromatography technology	Knelson EH (2013)	1
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
OCLN	1	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
TGFBR2	0	CDC6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAK1	2	TGFBR1	2	pull down, affinity chromatography technology	Barrios-Rodiles M (2005), Barrios-Rodiles M (2005)	2
NRP1	2	TGFBR2	0	affinity chromatography technology, pull down, affinity chromatography technology	Cao Y (2010), Glinka Y (2011), Glinka Y (2011)	3
TGFBR2	0	ENG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Barbara NP (1999), Barbara NP (1999), Blanco FJ (2005)	6
ERBB2	6	JAK1	6	unspecified method	Jones RB (2006)	1
CTNNB1	30	PIK3R1	6	pull down, imaging technique	Espada J (1999), Chen TC (2014)	2
TRIM25	5	TGFB1	2	affinity chromatography technology	Choudhury NR (2017)	1
NRP2	2	TGFBR2	0	affinity chromatography technology	Glinka Y (2011)	1
RCVRN	0	TGFBR2	0	two hybrid	Wang J (2011)	1
SMAD7	1	ACVR1	4	affinity chromatography technology	Kamiya Y (2010)	1
RASSF1	3	TGFBR2	0	affinity chromatography technology	Pefani DE (2016)	1
TGFBR1	2	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhang L (2013)	2
RASSF1	3	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TGFBR1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sorrentino A (2008), Kim SI (2009), Kim SI (2009), Zhang L (2013)	4
PEG10	2	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
TGFB1	2	DAXX	5	imaging technique	Chen TC (2014)	1
DAB2	1	APP	1	pull down	Morris SM (2001)	1
PIK3R3	0	PIK3CB	2	two hybrid, affinity chromatography technology	Grossmann A (2015), Huttlin EL (2017)	2
PDGFRA	3	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSP90AA1	7	TYK2	1	affinity chromatography technology	Taipale M (2012)	1
PTPRF	9	FAM171A2	1	bioid	St-Denis N (2016)	1
TGFBR2	0	DIP2A	12	affinity chromatography technology	Huttlin EL (2015)	1
ERBB2	6	PIK3R1	6	affinity chromatography technology, unspecified method	Crovello CS (1998), Jones RB (2006)	2
SNX6	1	PDGFRA	3	affinity chromatography technology	Parks WT (2001)	1
CDC42	3	IQGAP1	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuroda S (1996), Kuroda S (1996), Fukata M (2002), Hart MJ (1996), Hart MJ (1996), Joyal JL (1997), Zhang B (1998), Bourguignon LY (2005), Hein MY (2015), Hein MY (2015)	10
SMURF1	4	TRAF4	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, genetic interference, enzymatic study	Li S (2010), Li S (2010), Li S (2010), Li S (2010), Li S (2010), Zhang L (2013)	6
TRAF4	1	MAP3K7	2	affinity chromatography technology	Zhang L (2013)	1
TGFBR2	0	SBF1	15	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNX6	1	TGFBR2	0	affinity chromatography technology	Parks WT (2001)	1
PEG10	2	ACVR1	4	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
RASSF1	3	TGFBR1	2	affinity chromatography technology	Pefani DE (2016)	1
HSP90AA1	7	TGFBR2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wrighton KH (2008), Wrighton KH (2008), Wrighton KH (2008), Zhang K (2012), Zhang K (2012)	5
CBL	7	PIK3R3	0	two hybrid, two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015), Grossmann A (2015)	3
PEG10	2	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
GOPC	5	TGFBR2	0	two hybrid	Wang J (2011)	1
TRIM25	5	RAB6A	0	affinity chromatography technology	Choudhury NR (2017)	1