PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MMP2	2	COL5A1	1	affinity chromatography technology	Huttlin EL (2017)	1
FCGRT	0	IQCB1	3	affinity chromatography technology	Huttlin EL (2017)	1
MMP2	2	COL4A1	9	affinity chromatography technology	Huttlin EL (2017)	1
THBS1	6	COL5A1	1	pull down	Galvin NJ (1987)	1
ELAVL1	0	IQCB1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ITGB1	4	THBS1	6	affinity chromatography technology	Ashton AW (2004)	1
THBS1	6	ITGB3	6	pull down, affinity chromatography technology	Lawler J (1989), Ashton AW (2004)	2
YAP1	0	ITGB1	4	affinity chromatography technology	Enzo E (2015)	1
THBS1	6	COL2A1	9	pull down	Galvin NJ (1987)	1
FGA	5	ITGB3	6	unspecified method	Wierzbicka I (1997)	1
ITGB3	6	ITGAV	7	x-ray crystallography, imaging technique, affinity chromatography technology	Xiong JP (2002), Moon HE (2015), Ward CM (2000)	3
DDX31	1	THBS1	6	affinity chromatography technology	Huttlin EL (2017)	1
TGFB1	2	COL2A1	9	pull down	Zhu Y (1999)	1
THBS1	6	PDGFB	1	pull down	Hogg PJ (1997)	1
MMP2	2	ITGB1	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Kesanakurti D (2012), Kesanakurti D (2012), Kesanakurti D (2012)	3
COL2A1	9	PDGFB	1	pull down, far western blotting	Somasundaram R (1996), Somasundaram R (1996)	2
SOX2	4	THBS1	6	affinity chromatography technology	Cox JL (2013)	1
MMP2	2	ITGB3	6	affinity chromatography technology	Kesanakurti D (2012)	1
FGF2	1	THBS1	6	pull down, pull down	Margosio B (2007), Margosio B (2007)	2
TFPI	0	THBS1	6	pull down	Mast AE (2000)	1
ITGAV	7	THBS1	6	affinity chromatography technology	Ashton AW (2004)	1
ELAVL1	0	YAP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	TFPI	0	affinity chromatography technology	Abdelmohsen K (2009)	1
MMP9	1	THBS2	2	affinity chromatography technology	Bein K (2000)	1
MMP9	1	COL4A1	9	affinity chromatography technology	Huttlin EL (2017)	1
COL1A1	1	ITGB1	4	biochemical	Staatz WD (1990)	1
YAP1	0	THBS1	6	affinity chromatography technology	Enzo E (2015)	1
COL1A1	1	PDGFB	1	pull down, far western blotting	Somasundaram R (1996), Somasundaram R (1996)	2
COL7A1	19	COL4A1	9	pull down	Chen M (1997)	1
F2	2	FGA	5	x-ray crystallography, imaging technique	Stubbs MT (1992), Chen TC (2014)	2
MMP2	2	ITGAV	7	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kesanakurti D (2012), Kesanakurti D (2012), Kesanakurti D (2012), Kesanakurti D (2012)	4
COL1A1	1	MMP2	2	pull down	Ellerbroek SM (2001)	1
THBS1	6	COL4A1	9	pull down	Galvin NJ (1987)	1
FCGRT	0	THBS1	6	affinity chromatography technology	Huttlin EL (2017)	1
IQCB1	3	THBS1	6	affinity chromatography technology	Sang L (2011)	1
MMP9	1	TGFB1	2	enzymatic study, imaging technique	Yu Q (2000), Chen TC (2014)	2
MMP2	2	COL2A1	9	affinity chromatography technology	Huttlin EL (2017)	1
THBS1	6	FGA	5	pull down	Panetti TS (1999)	1
MMP2	2	TGFB1	2	enzymatic study, imaging technique	Yu Q (2000), Chen TC (2014)	2
THBS1	6	IGFBP5	0	pull down	Nam TJ (2000)	1
COL7A1	19	COL1A1	1	pull down	Chen M (1997)	1
CALCR	0	THBS1	6	pull down	Goicoechea S (2002)	1
THBS1	6	ELANE	0	pull down	Hogg PJ (1993)	1
ELAVL1	0	ITGB1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
COL3A1	4	PDGFB	1	pull down, far western blotting	Somasundaram R (1996), Somasundaram R (1996)	2
ITGB3	6	ITGB1	4	imaging technique	Moon HE (2015)	1
ELAVL1	0	THBS1	6	affinity chromatography technology	Abdelmohsen K (2009)	1
THBS3	3	THBS1	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MMP9	1	COL5A1	1	affinity chromatography technology	Huttlin EL (2017)	1
LRP1	25	PDGFB	1	pull down	Loukinova E (2002)	1
THBS1	6	MMP2	2	two hybrid, affinity chromatography technology	Bein K (2000), Bein K (2000)	2
ELAVL1	0	COL1A1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CALCR	0	LRP1	25	pull down, affinity chromatography technology	Orr AW (2003), Orr AW (2003)	2
THBS1	6	PLG	3	pull down, pull down	Silverstein RL (1984), DePoli P (1989)	2
SCARB2	2	THBS1	6	pull down	Crombie R (1998)	1
LRP2	13	THBS1	6	pull down	Godyna S (1995)	1
COL4A1	9	PDGFB	1	pull down, far western blotting	Somasundaram R (1996), Somasundaram R (1996)	2
THBS2	2	MMP2	2	two hybrid, affinity chromatography technology	Bein K (2000), Bein K (2000)	2
ITGAV	7	ITGB1	4	biochemical, pull down, imaging technique	Wan C (2015), Hu B (2006), Moon HE (2015)	3
MMP9	1	THBS1	6	affinity chromatography technology	Bein K (2000)	1
THBS1	6	F2	2	pull down	Asch AS (1987)	1
THBS1	6	COL7A1	19	two hybrid	Aho S (1998)	1
MMP9	1	COL2A1	9	affinity chromatography technology	Huttlin EL (2017)	1
THBS1	6	COL1A1	1	pull down	Galvin NJ (1987)	1
TGFB1	2	THBS1	6	biochemical	Murphy-Ullrich JE (1992)	1
THBS1	6	LRP1	25	pull down, pull down, pull down	Wang S (2004), Mikhailenko I (1997), Godyna S (1995)	3
PSMD4	1	THBS1	6	affinity chromatography technology	Zhou J (2004)	1
COL5A1	1	PDGFB	1	pull down, far western blotting	Somasundaram R (1996), Somasundaram R (1996)	2
THBS1	6	COL3A1	4	pull down	Galvin NJ (1987)	1
THBS2	2	THBS1	6	affinity chromatography technology	Huttlin EL (2017)	1