PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KLF10	1	SF3B3	4	two hybrid	Vinayagam A (2011)	1
KLF10	1	RPL14	2	two hybrid	Vinayagam A (2011)	1
KDM5B	27	KLF10	1	pull down, affinity chromatography technology	Kim J (2010), Kim J (2010)	2
KLF10	1	LRRC75A-AS1	0	two hybrid	Vinayagam A (2011)	1
KLF10	1	CRIP2	0	two hybrid	Vinayagam A (2011)	1
CDK2	0	RPL14	2	affinity chromatography technology	Neganova I (2011)	1
KLF10	1	KAT2B	2	pull down	Xiong Y (2014)	1
KLF10	1	TNS1	6	two hybrid	Vinayagam A (2011)	1
KLF10	1	LENG1	2	two hybrid	Vinayagam A (2011)	1
CDK2	0	CDK6	0	biochemical, imaging technique	Cheng A (2000), Chen TC (2014)	2
CDK2	0	SF3B3	4	affinity chromatography technology	Neganova I (2011)	1
KLF10	1	SIAH1	2	two hybrid, affinity chromatography technology, pull down	Johnsen SA (2002), Johnsen SA (2002), Lin CH (2015)	3
CDK6	0	KLF10	1	enzymatic study	Anders L (2011)	1
KLF10	1	23246	0	two hybrid	Vinayagam A (2011)	1
KLF10	1	ITCH	1	affinity chromatography technology, affinity chromatography technology	Venuprasad K (2008), Venuprasad K (2008)	2
KLF10	1	PIGC	2	two hybrid	Vinayagam A (2011)	1
CDK2	0	SP1	0	enzymatic study	Fojas de Borja P (2001)	1
ZNF512B	2	KLF10	1	two hybrid	Colland F (2004)	1
CCNE1	1	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
KLF10	1	CDK2	0	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Lin CH (2015), Lin CH (2015), Lin CH (2015), Lin CH (2015)	4
KLF10	1	CCNE1	1	affinity chromatography technology, affinity chromatography technology	Lin CH (2015), Lin CH (2015)	2
KLF10	1	TYK2	1	affinity chromatography technology, affinity chromatography technology	Peng DJ (2011), Peng DJ (2011)	2
SP1	0	KLF10	1	pull down, pull down	Gunther M (2000), Noti JD (2004)	2
SIAH1	2	ZNF512B	2	two hybrid	Rolland T (2014)	1
KLF10	1	SIN3A	13	pull down, affinity chromatography technology	Zhang JS (2001), Xiong Y (2014)	2
SP1	0	SIN3A	13	affinity chromatography technology	Plaisance V (2005)	1
KAT2B	2	CDK2	0	pull down, affinity chromatography technology, enzymatic study	Mateo F (2009), Mateo F (2009), Mateo F (2009)	3
CCNE1	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McKenzie PP (2003), Shanahan F (1999), Koff A (1992), Koff A (1992), Mayer C (2004), Connor MK (2003), Boudrez A (2000), Varshochi R (2005), Jeong JH (2010), Bustany S (2011), Yeh ES (2006), Hui S (2011), Kim J (2007), Kiviharju-af Haellstroem TM (2007), Abbas T (2007), Nishimura T (2005), Matsumoto Y (2004), Harwell RM (2004), Harwell RM (2004), Peiretti A (2003), Peiretti A (2003), Kim YB (2000), Manenti S (1999), Datta NS (1998), Sheaff RJ (1997), Higashi H (1996), Higashi H (1996), Musgrove EA (1996), Vlach J (1996), Grim JE (2008), Liu S (2009), Ciarallo S (2002), Desai D (1995), Baydoun HH (2010), Baydoun HH (2010), Chu I (2007), Chu I (2007), Levkau B (1998), Poon RY (1996), Zhao J (1998), Zhao J (1998), Larrea MD (2009), Varjosalo M (2013), Varjosalo M (2013), Chan HM (2001), So J (2015), Ungermannova D (2005), Song MS (2011), Huttlin EL (2015), Hein MY (2015), Lin CH (2015), Lin CH (2015), Davis RJ (2017), Huttlin EL (2017)	54