PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CHCHD10	1	PRRC2A	10	affinity chromatography technology	Huttlin EL (2017)	1
GNAS	9	MAGED2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Laghmani K (2016), Huttlin EL (2017)	3
PRKN	1	RPS2	3	affinity chromatography technology	Zanon A (2013)	1
ZNF707	2	MRPS22	0	affinity chromatography technology	Huttlin EL (2015)	1
LUC7L	2	LUC7L2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UIMC1	4	UBC	7	pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, unspecified method, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Sobhian B (2007), Sobhian B (2007), Wang B (2009), Hu X (2012), Sekiyama N (2012), Cho HJ (2009), Markin CJ (2010), Sekiyama N (2012), Sekiyama N (2012), Sato Y (2009), Sato Y (2009), Nikkilae J (2009), Nikkilae J (2009), Wu J (2009), Guzzo CM (2012), Nathan JA (2013), Anamika A (2014), Kensche T (2012), Yan J (2007), Castaneda CA (2013), Nakasone MA (2013), Thach TT (2015), Zhang X (2017), Li Y (2017), Kristariyanto YA (2017)	25
FBL	1	C1QBP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yanagida M (2004), Huttlin EL (2015), Huttlin EL (2017)	3
CHCHD10	1	LUC7L	2	affinity chromatography technology	Huttlin EL (2017)	1
LUC7L2	0	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UIMC1	4	C1QBP	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Cho HJ (2013), Chung HJ (2017), Chung HJ (2017), Chung HJ (2017), Chung HJ (2017)	5
C1QBP	0	PRRC2A	10	two hybrid, two hybrid	Lehner B (2004), Lehner B (2004)	2
C1QBP	0	DAP3	1	affinity chromatography technology, affinity chromatography technology	Yagi M (2012), Yagi M (2012)	2
YWHAE	0	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Choudhary C (2009)	2
BEND7	0	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
C1QBP	0	PRKCZ	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Storz P (2000), Storz P (2000), Chen R (2013), So J (2015)	4
FBL	1	RPS2	3	biochemical	Havugimana PC (2012)	1
MAGED2	1	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Huttlin EL (2017)	2
C1QBP	0	PRKD1	7	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Storz P (2000), Storz P (2000), Storz P (2000), Storz P (2000)	4
RPS2	3	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RSRP1	0	C1QBP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
C1QBP	0	PRKCA	7	pull down, affinity chromatography technology	Storz P (2000), Storz P (2000)	2
OSM	0	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
C1QBP	0	TFAM	1	affinity chromatography technology, affinity chromatography technology	Yagi M (2012), Yagi M (2012)	2
PRKCA	7	HABP4	1	enzymatic study	Nery FC (2004)	1
LUC7L	2	PRRC2A	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
HABP4	1	C1QBP	0	two hybrid, two hybrid	Nery FC (2006), Bressan GC (2009)	2
ZNF707	2	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNF524	0	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHST8	3	FBL	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DAP3	1	MRPS22	0	biochemical	Wan C (2015)	1
UBC	7	PPP2R1A	8	affinity chromatography technology	Matsumoto M (2005)	1
C1QBP	0	MRPS22	0	affinity chromatography technology, affinity chromatography technology	Yagi M (2012), Yagi M (2012)	2
ZRSR2	0	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	DAP3	1	affinity chromatography technology	Matsumoto M (2005)	1
PRKN	1	DAP3	1	affinity chromatography technology	Zanon A (2013)	1
PRKN	1	YWHAE	0	affinity chromatography technology	Zanon A (2013)	1
PPP2R1A	8	TFAM	1	affinity chromatography technology	Fogeron ML (2013)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
CHCHD10	1	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Floyd BJ (2016), Huttlin EL (2017)	2
UBC	7	MRPS22	0	affinity chromatography technology	Matsumoto M (2005)	1
C1QBP	0	PRKN	1	affinity chromatography technology, affinity chromatography technology	Li Y (2011), Zanon A (2013)	2
C1QBP	0	PRKCD	2	pull down, affinity chromatography technology	Storz P (2000), Storz P (2000)	2
ZNF707	2	DAP3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	FBL	1	affinity chromatography technology	Matsumoto M (2005)	1
PRKN	1	MRPS22	0	affinity chromatography technology	Zanon A (2013)	1
RSPO1	3	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LUC7L	2	MRPS22	0	affinity chromatography technology	Huttlin EL (2015)	1
PPP2R1A	8	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Aranda-Orgilles B (2008), Hein MY (2015)	2
GNAS	9	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHST8	3	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LUC7L	2	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2