PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZMYM2	5	RCOR1	0	affinity chromatography technology, pull down	Gocke CB (2008), Gocke CB (2008)	2
RCOR1	0	HDAC1	4	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Gocke CB (2008), Battaglioli E (2002), Gu H (2005), Pflum MK (2001), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Cetinkaya C (2007), Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	15
SP1	0	DDX5	2	pull down	Miyamoto-Sato E (2010)	1
NR2E1	0	DGCR8	4	affinity chromatography technology, affinity chromatography technology	Murai K (2016), Murai K (2016)	2
HDAC7	4	HDAC2	1	pull down	Dressel U (2001)	1
NR2E1	0	DCAF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR2E1	0	MTDH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RERE	9	NR2E1	0	pull down	Wang L (2006)	1
RERE	9	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Wang L (2006), Bantscheff M (2011)	2
IMPDH1	2	DDX5	2	biochemical	Wan C (2015)	1
NR2E1	0	GSE1	14	affinity chromatography technology	Yokoyama A (2008)	1
DGCR8	4	DROSHA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shiohama A (2007), Li S (2014), Li S (2014), Hein MY (2015), Huttlin EL (2017)	5
NR2E1	0	RGPD5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC3	5	NR2E1	0	affinity chromatography technology, affinity chromatography technology	Sun G (2007), Sun G (2007)	2
ERBIN	5	NR2E1	0	unspecified method	Boisguerin P (2004)	1
SP1	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won J (2002), Zhang Y (2002), Sun JM (2002), Glasspool RM (2005), Duan H (2005), Sekhavat A (2007), Itoh Y (2007), Marshall GM (2010), Tsai PF (2011), Schnur N (2007)	10
HDAC5	4	NR2E1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun G (2007), Sun G (2007), Murai K (2016)	3
KDM1A	2	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cui S (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013)	4
RERE	9	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang L (2006), Joshi P (2013), Shen Y (2007), Hein MY (2015), Huttlin EL (2017)	5
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
HDAC3	5	SP1	0	affinity chromatography technology	Huang W (2006)	1
NR2E1	0	HDAC1	4	affinity chromatography technology	Yokoyama A (2008)	1
HDAC7	4	HDAC5	4	pull down	Dressel U (2001)	1
NR2E1	0	CARNMT1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RERE	9	ATN1	2	pull down, pull down, two hybrid, two hybrid	Yanagisawa H (2000), Yanagisawa H (2000), Lim J (2006), Lim J (2006)	4
ZMYM2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gocke CB (2008), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	4
NR2E1	0	TMSB10	0	affinity chromatography technology	Huttlin EL (2015)	1
ATN1	2	NR2E1	0	pull down	Wang L (2006)	1
HDAC1	4	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2003), You A (2001), You A (2001), Shi YJ (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Godmann M (2007), Godmann M (2007), Terhune SS (2010), Godmann M (2010), Godmann M (2010), Wang Y (2009), Nicholson TB (2011), Li Q (2011), Cui S (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Wang Q (2016), Huttlin EL (2017)	26
NR2E1	0	IMPDH1	2	affinity chromatography technology	Huttlin EL (2015)	1
DDX5	2	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Mooney SM (2010), Mooney SM (2010)	2
NR2E1	0	KDM1A	2	affinity chromatography technology, affinity chromatography technology, pull down	Yokoyama A (2008), Yokoyama A (2008), Yokoyama A (2008)	3
NR2E1	0	DDX5	2	affinity chromatography technology	Murai K (2016)	1
NR2E1	0	DROSHA	0	affinity chromatography technology, affinity chromatography technology	Murai K (2016), Murai K (2016)	2
HDAC3	5	RCOR1	0	affinity chromatography technology	Joshi P (2013)	1
NR2E1	0	UPF3B	6	affinity chromatography technology	Huttlin EL (2015)	1
CARNMT1	2	HDAC1	4	affinity chromatography technology	Huttlin EL (2017)	1
NR2E1	0	CIZ1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR2E1	0	BCL11A	14	pull down, two hybrid, affinity chromatography technology, two hybrid	Chan CM (2013), Chan CM (2013), Chan CM (2013), Chan CM (2013)	4
SP1	0	NR2E1	0	affinity chromatography technology, affinity chromatography technology	Elmi M (2010), Elmi M (2010)	2
DGCR8	4	DDX5	2	affinity chromatography technology	Shiohama A (2007)	1
BCL11A	14	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cismasiu VB (2005), Joshi P (2013), Huttlin EL (2017)	3
HDAC2	1	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, genetic interference	Hakimi MA (2002), Hakimi MA (2003), Hakimi MA (2003), Hakimi MA (2003), Tong JK (1998), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Wang Y (2009), Li Q (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Wong AS (2016)	17
HDAC2	1	ZMYM2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Gocke CB (2008), Bantscheff M (2011), Joshi P (2013)	4
NR2E1	0	SUFU	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DROSHA	0	DDX5	2	affinity chromatography technology, affinity chromatography technology	Hong S (2013), Hong S (2013)	2
DNMT3L	2	NR2E1	0	pull down	Pacaud R (2014)	1
NSD1	25	NR2E1	0	two hybrid	Chan CM (2013)	1
SP1	0	DCAF6	0	affinity chromatography technology	Chen PH (2008)	1
NR2E1	0	TNRC6C	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR2E1	0	VRK3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR2E1	0	ZMYM2	5	affinity chromatography technology	Yokoyama A (2008)	1
HDAC1	4	DDX5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wilson BJ (2004), Wilson BJ (2004), Guo J (2010), Jacobs AM (2007), Mooney SM (2010), Mooney SM (2010)	6
HDAC5	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Zhang J (2002), Grozinger CM (2000), Greco TM (2011), Greco TM (2011)	6
NR2E1	0	HDAC2	1	affinity chromatography technology	Yokoyama A (2008)	1
NR2E1	0	ARL10	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC5	4	HDAC1	4	affinity chromatography technology	Greco TM (2011)	1
HDAC1	4	GSE1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	4
RCOR1	0	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Gocke CB (2008), Chen Y (2006), Yang M (2006), Shi YJ (2005), Shi YJ (2005), Lee MG (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Hwang S (2011), Lin Y (2010), Nicholson TB (2011), Nicholson TB (2011), Cui S (2011), Adamo A (2011), Adamo A (2011), Bantscheff M (2011), Mosammaparast N (2013), Lin Y (2010), Wan C (2015), Boldt K (2016)	25
HDAC7	4	HDAC1	4	pull down	Dressel U (2001)	1
RCOR1	0	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Battaglioli E (2002), Humphrey GW (2001), Humphrey GW (2001), Bantscheff M (2011), Joshi P (2013)	8
NR2E1	0	GNB4	2	affinity chromatography technology	Huttlin EL (2015)	1
HDAC2	1	BCL11A	14	affinity chromatography technology	Joshi P (2013)	1
HDAC7	4	NR2E1	0	affinity chromatography technology	Sun G (2007)	1
NR2E1	0	RCOR1	0	affinity chromatography technology, affinity chromatography technology	Yokoyama A (2008), Yokoyama A (2008)	2
HDAC7	4	HDAC3	5	pull down, affinity chromatography technology, affinity chromatography technology	Fischle W (2001), Fischle W (2001), Joshi P (2013)	3
DNMT3L	2	HDAC1	4	pull down, pull down, pull down, pull down, affinity chromatography technology	Aapola U (2002), Aapola U (2002), Deplus R (2002), Deplus R (2002), Deplus R (2002)	5
SMURF1	4	NR2E1	0	affinity chromatography technology	Johansson E (2016)	1
SMURF1	4	DDX5	2	affinity chromatography technology	Xie Y (2013)	1
SP1	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Di Padova M (2003), Singh J (2002), Zhang Y (2002), Sun JM (2002), Gao J (2009), Shon JK (2009), Mottet D (2009), Goto T (2006), Hung JJ (2006), Lagger G (2003), Choi HS (2002), Choi HS (2002), Kang JE (2005), Kang JE (2005), Kang JE (2005), Gan Y (2005), Gan Y (2005), Duan H (2005), Varshochi R (2005), Varshochi R (2005), Plaisance V (2005), Walker GE (2001), Walker GE (2001), Ammanamanchi S (2004), Doetzlhofer A (1999), Sekhavat A (2007), Liu T (2007), Enya K (2008), Liu S (2010), Leclerc GJ (2010), Leclerc GJ (2010), Wong CY (2011), Schnur N (2007)	33
KDM1A	2	ZMYM2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Gocke CB (2008), Shi YJ (2005), Lee MG (2005)	4
KDM1A	2	GSE1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Lee MG (2005), Bantscheff M (2011)	3
NR2E1	0	TWISTNB	1	affinity chromatography technology	Huttlin EL (2015)	1
DDX5	2	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Mooney SM (2010), Mooney SM (2010)	2
HDAC2	1	GSE1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Bantscheff M (2011), Joshi P (2013)	3