PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PLK1	0	TMF1	2	affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Huttlin EL (2017)	2
TMEM216	0	TMF1	2	bioid	Gupta GD (2015)	1
CCDC183	3	TMF1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BSPRY	2	TMF1	2	affinity chromatography technology	Huttlin EL (2017)	1
TCP10L2	2	TMF1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMF1	2	AR	3	pull down, two hybrid, far western blotting	Hsiao PW (1999), Hsiao PW (1999), Hsiao PW (1999)	3
FOXK2	9	TMF1	2	affinity chromatography technology	Li X (2015)	1
PPM1H	3	TMF1	2	bioid	St-Denis N (2016)	1
NR3C1	2	TMF1	2	pull down	Miyamoto-Sato E (2010)	1
FER	1	TMF1	2	two hybrid, enzymatic study	Schwartz Y (1998), Schwartz Y (1998)	2
GFI1B	1	TMF1	2	two hybrid	Lim J (2006)	1
AP1M2	2	TMF1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP7	14	TMF1	2	affinity chromatography technology	Hein MY (2015)	1
ITSN2	7	TMF1	2	two hybrid	Wong KA (2012)	1
AR	3	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Chen ST (2015), Chen ST (2015), Chen ST (2015), Chen ST (2015)	4
KAT2B	2	TMF1	2	two hybrid	Albers M (2005)	1
PDHA1	7	TMF1	2	affinity chromatography technology	Malty RH (2017)	1
AR	3	KAT2B	2	pull down, enzymatic study	Fu M (2000), Fu M (2000)	2