PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UPF2	2	TNNI2	2	two hybrid	Lehner B (2004)	1
TNNI2	2	TLE1	6	affinity chromatography technology	Huttlin EL (2017)	1
ESRRA	2	TNNI2	2	two hybrid	Albers M (2005)	1
TNNI2	2	RFTN2	2	affinity chromatography technology	Huttlin EL (2017)	1
TNNI2	2	NUCB2	1	affinity chromatography technology	Huttlin EL (2017)	1
HNF4G	1	TNNI2	2	two hybrid	Albers M (2005)	1
TLE4	5	TLE1	6	affinity chromatography technology	Huttlin EL (2017)	1
RORB	3	TNNI2	2	two hybrid	Albers M (2005)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
ESRRA	2	SIRT1	3	pull down, enzymatic study	Wilson BJ (2010), Wilson BJ (2010)	2
TNNI2	2	TLE4	5	affinity chromatography technology	Huttlin EL (2017)	1
TRIM63	0	TNNI2	2	two hybrid, two hybrid	Witt SH (2005), Witt CC (2008)	2
TRIM55	2	TNNI2	2	two hybrid	Witt CC (2008)	1
SIRT1	3	TLE1	6	two hybrid, affinity chromatography technology	Ghosh HS (2007), Ghosh HS (2007)	2
TRIM63	0	TNNC1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Kedar V (2004), Kedar V (2004), Kedar V (2004), Kedar V (2004), Kedar V (2004)	5
TNNI2	2	KLHL21	3	affinity chromatography technology	Huttlin EL (2017)	1
TNNI2	2	SIRT1	3	affinity chromatography technology	Huttlin EL (2017)	1
TNNC1	2	TNNI2	2	x-ray crystallography	Grand RJ (1982)	1