PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MST1	1	TNNC1	2	enzymatic study	You B (2009)	1
AKAP1	3	TNNI3	0	affinity chromatography technology	Hein MY (2015)	1
HSPB2	1	TNNI3	0	two hybrid	Grose JH (2015)	1
TNNC1	2	TNNT2	1	two hybrid	Mogensen J (2004)	1
PKD2	1	TNNI3	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Li Q (2003), Li Q (2003), Li Q (2003), Li Q (2003)	4
RCAN3	0	TNNI3	0	two hybrid, pull down, protein complementation assay	Canaider S (2006), Canaider S (2006), Canaider S (2006)	3
PSMC5	4	TNNI3	0	two hybrid	Albers M (2005)	1
MST1	1	TNNI3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	You B (2009), You B (2009), You B (2009), You B (2009)	4
TRIM63	0	TNNI3	0	two hybrid, enzymatic study	Witt CC (2008), Kim HT (2007)	2
PKD2L1	3	TNNI3	0	two hybrid, affinity chromatography technology, pull down	Li Q (2003), Li Q (2003), Li Q (2003)	3
TNNI3	0	IFNA4	3	affinity chromatography technology	Huttlin EL (2017)	1
SOX4	5	TNNI3	0	two hybrid	Jang SM (2015)	1
TNNI3	0	TNNT2	1	pull down, pull down	Schmidtmann A (2002), You B (2009)	2
TNNC2	1	TNNI3	0	two hybrid	Rolland T (2014)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
TNNI3K	0	TNNI3	0	two hybrid, affinity chromatography technology	Zhao Y (2003), Zhao Y (2003)	2
TRIM63	0	TNNC1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Kedar V (2004), Kedar V (2004), Kedar V (2004), Kedar V (2004), Kedar V (2004)	5
TRIM55	2	TNNI3	0	two hybrid	Witt CC (2008)	1
LYST	8	TNNI3	0	two hybrid	Tchernev VT (2002)	1
TNNI3	0	TNNC1	2	pull down, pull down, pull down, x-ray crystallography, unspecified method, pull down, pull down	Ward DG (2004), Ward DG (2004), Ward DG (2003), Wang X (2002), Li MX (2002), al-Hillawi E (1994), You B (2009)	7
MST1	1	TNNT2	1	enzymatic study	You B (2009)	1