Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
TPH1 7166 TELOTRISTAT CHEMBL2103855 antagonist, inhibitor ChemblInteractions, DrugBank
TPH1 7166 FENFLURAMINE CHEMBL87493 inhibitor GuideToPharmacologyInteractions
TPH1 7166 SAPROPTERIN CHEMBL1201774 cofactor TdgClinicalTrial, TEND, DrugBank 2665179, 12414107, 10381000, 11472242, 15223360
TPH1 7166 CHEMBL472222 CHEMBL472222 inhibitor GuideToPharmacologyInteractions
TPH1 7166 TELOTRISTAT ETHYL CHEMBL2105695 inhibitor GuideToPharmacologyInteractions, ChemblInteractions
TPH1 7166 LITHIUM CHEMBL2146126 PharmGKB
TPH1 7166 FENCLONINE CHEMBL1256351 inhibitor GuideToPharmacologyInteractions
TPH1 7166 ROPINIROLE CHEMBL589 inhibitor GuideToPharmacologyInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
TPH1 rs1800532 GT + TT citalopram efficacy yes This association with worse treatment outcome is only significant associated in patients with major depression clinical features psychotic (F(6, 378) = 2.90; p = 0.009) and melancholic (F(6, 381) = 2.86; p = 0.0097). Genotypes GT + TT are associated with decreased response to citalopram in people with Depressive Disorder, Major as compared to genotype GG. 23221997 982023021
TPH1 rs1800532 GG antidepressants efficacy no Genotype GG is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to genotypes GT + TT. 23733030 982028731
TPH1 rs1800532 GT + TT escitalopram efficacy yes Genotypes GT + TT are associated with decreased response to escitalopram in people with Depression as compared to genotype GG. 31721892 1451148543
TPH1 rs1799913 TT lithium efficacy not stated This is from a review article which does not give all the details. Genotype TT is associated with decreased response to lithium in people with Bipolar Disorder. 21047205 699639287
TPH1 rs1800532 TT lithium efficacy not stated This is from a review article which does not give all the details Genotype TT is associated with decreased response to lithium in people with Bipolar Disorder. 21047205 699639285
TPH1 rs1800532 T citalopram efficacy no This SNP was also not found to be associated with Major Depressive Disorder. Allele T is not associated with response to citalopram, fluoxetine or paroxetine in people with Depressive Disorder, Major as compared to allele G. 19590397 981750815
TPH1 rs1800532 G venlafaxine efficacy no Response assessed as remission, defined as MADRS score =<10 at the end of treatment. Allele G is not associated with response to venlafaxine in people with Depressive Disorder, Major as compared to allele T. 28068779 1448601874