Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
TRAF1	rs3761847	A	adalimumab	efficacy	no		Allele A is not associated with response to adalimumab, etanercept, infliximab or Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Arthritis, Rheumatoid as compared to allele G.	23007924	981417500
TRAF1	rs3761847	G	Tumor necrosis factor alpha	efficacy	yes	using either the absolute change in DAS28 or the proportion of good responders and non-responders as outcomes. The G allele is also a susceptibility factor for RA related to TNF signaling.	Allele G is associated with decreased response to Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Arthritis, Rheumatoid as compared to allele A.	25834819	1444702631
TRAF1	rs1081848	GG	rituximab	efficacy	no	No significant association was seen between genotype and whether a patient was a "responder" or a "non-responder". "Responders" had a post-rituximab disease activity score (DAS28) of lower than 5.1 and a DAS28 variation between baseline and post-treatment higher than 0.6.	Genotype GG is not associated with response to rituximab in people with Arthritis, Rheumatoid as compared to genotypes AA + AG.	22129793	982047114