Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CCT3 7203 CHEMBL1230989 CHEMBL1230989 DrugBank 10592235

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CCT3 rs12138564 T bevacizumab efficacy no GWAS in discovery and replication cohort the T allele was nominally associated with improved response (as assessed by improvements in visual acuity (VA)) but only nominally after multiple testing correction. The GT genotype was associated with greater improvement in VA as compared to the GG genotype (P = .008), but the TT was associated with the largest improvement in VA (P = .002). Allele T is associated with increased response to bevacizumab and ranibizumab in people with Macular Degeneration as compared to allele G. 29852030 1449566942