PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCM2	3	EWSR1	2	affinity chromatography technology	Drissi R (2015)	1
CALM1	0	SQSTM1	0	pull down	Shen X (2005)	1
CRYAB	0	ALB	1	affinity chromatography technology	Rothbard JB (2011)	1
CPSF6	1	TTN	102	biochemical	Havugimana PC (2012)	1
MCM2	3	TUBA1A	13	affinity chromatography technology	Drissi R (2015)	1
EGFR	5	TOP1	1	affinity chromatography technology	Liccardi G (2014)	1
CUL3	17	RBM3	1	affinity chromatography technology	Bennett EJ (2010)	1
SQSTM1	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanji K (2012), Chen K (2016), Chen K (2016)	3
MCM2	3	TTN	102	affinity chromatography technology	Drissi R (2015)	1
CHEK2	2	CHEK1	2	genetic interference	Srivas R (2016)	1
TTN	102	ANKRD2	3	pull down	Miller MK (2003)	1
MCM2	3	MAPK1	1	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	YWHAQ	0	affinity chromatography technology	Drissi R (2015)	1
TTN	102	TRIM63	0	two hybrid, pull down, two hybrid, x-ray crystallography, pull down, two hybrid	Centner T (2001), Centner T (2001), Witt SH (2005), Mrosek M (2007), Bogomolovas J (2014), Witt CC (2008)	6
MAPK1	1	ARRB1	2	enzymatic study	Lin FT (1999)	1
TTN	102	NBR1	0	two hybrid, affinity chromatography technology, enzymatic study	Lange S (2005), Lange S (2005), Lange S (2005)	3
COPS5	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
BRCA1	7	EWSR1	2	affinity chromatography technology	Ertych N (2016)	1
CUL2	3	TTN	102	affinity chromatography technology	Bennett EJ (2010)	1
ADAM2	1	TTN	102	affinity chromatography technology	Huttlin EL (2017)	1
TRIM55	2	TCAP	0	two hybrid	Witt CC (2008)	1
YWHAQ	0	LMNA	2	affinity chromatography technology, pull down	Pozuelo-Rubio M (2010), Meek SE (2004)	2
LMNA	2	FHL1	1	bioid	Roux KJ (2012)	1
HEY1	2	TTN	102	affinity chromatography technology	Lopez-Mateo I (2016)	1
SRPK2	1	SRSF2	0	enzymatic study, affinity chromatography technology, enzymatic study	Wang HY (1998), Varjosalo M (2013), Jang SW (2009)	3
CUL7	4	ACTN1	5	affinity chromatography technology	Hanson D (2014)	1
CUL7	4	SQSTM1	0	affinity chromatography technology	Hanson D (2014)	1
MCM2	3	CUL4B	8	affinity chromatography technology	Drissi R (2015)	1
RNF2	1	EWSR1	2	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	TTN	102	affinity chromatography technology	Cao Q (2014)	1
TOP3A	0	TTN	102	genetic interference	Srivas R (2016)	1
TTN	102	OBSCN	32	two hybrid, pull down, two hybrid, affinity chromatography technology	Young P (2001), Young P (2001), Arimura T (2007), Arimura T (2007)	4
UBE2A	0	OBSCN	32	affinity chromatography technology	An H (2017)	1
ADAM2	1	CRYAB	0	affinity chromatography technology	Cottrell BA (2005)	1
CUL2	3	YWHAQ	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	RBM3	1	affinity chromatography technology	Bennett EJ (2010)	1
TTN	102	CRYAB	0	affinity chromatography technology	Bullard B (2004)	1
NTRK1	1	SRPK2	1	affinity chromatography technology	Emdal KB (2015)	1
CUL7	4	PUF60	16	affinity chromatography technology	Hanson D (2014)	1
CUL7	4	TOP1	1	affinity chromatography technology	Hanson D (2014)	1
TOP1	1	WEE1	2	genetic interference	Srivas R (2016)	1
TUBA1A	13	CHEK2	2	genetic interference	Srivas R (2016)	1
NTRK1	1	COPS5	0	affinity chromatography technology	Emdal KB (2015)	1
CUL7	4	TOP2A	2	affinity chromatography technology	Hanson D (2014)	1
RNF2	1	TOP1	1	affinity chromatography technology	Cao Q (2014)	1
CEP57	0	TTN	102	affinity chromatography technology	Fogeron ML (2013)	1
CDH1	4	TTN	102	bioid	Guo Z (2014)	1
CHEK2	2	WEE1	2	genetic interference	Srivas R (2016)	1
SQSTM1	0	NBR1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	DAgostino C (2011), Lange S (2005), Lamark T (2003), Lamark T (2003), Yang JQ (2010), Erdogan E (2006), Yamashita SI (2014), Nicot AS (2014)	8
BRCA1	7	LMNA	2	affinity chromatography technology	Ertych N (2016)	1
LMNA	2	TOP2A	2	bioid	Roux KJ (2012)	1
CUL3	17	TTN	102	affinity chromatography technology	Bennett EJ (2010)	1
TOP2A	2	TOP1	1	biochemical	Wan C (2015)	1
NTRK1	1	SRSF2	0	affinity chromatography technology	Emdal KB (2015)	1
ASF1B	0	TTN	102	affinity chromatography technology	Ewing RM (2007)	1
COPS5	0	PUF60	16	affinity chromatography technology	Bennett EJ (2010)	1
TOP2A	2	WEE1	2	genetic interference	Srivas R (2016)	1
TOP2A	2	COPS5	0	affinity chromatography technology, two hybrid, pull down	Chen MC (2011), Yun J (2004), Yun J (2004)	3
ANK1	8	OBSCN	32	two hybrid, pull down, affinity chromatography technology	Kontrogianni-Konstantopoulos A (2003), Kontrogianni-Konstantopoulos A (2003), Lange S (2012)	3
TRIM55	2	TTN	102	two hybrid	Witt CC (2008)	1
NTRK1	1	TOP3A	0	affinity chromatography technology	Emdal KB (2015)	1
MAPK1	1	FHL2	0	two hybrid, pull down, pull down, affinity chromatography technology	Purcell NH (2004), Purcell NH (2004), Purcell NH (2004), Purcell NH (2004)	4
NTRK1	1	EWSR1	2	affinity chromatography technology	Emdal KB (2015)	1
CDK2	0	LMNA	2	affinity chromatography technology	Neganova I (2011)	1
UBE2A	0	PUF60	16	affinity chromatography technology	An H (2017)	1
CPSF6	1	PUF60	16	biochemical	Havugimana PC (2012)	1
SP1	0	TTN	102	affinity chromatography technology	Chuang JY (2012)	1
TRIM55	2	SQSTM1	0	affinity chromatography technology, two hybrid	Lange S (2005), Witt CC (2008)	2
BRCA1	7	TTN	102	affinity chromatography technology	Ertych N (2016)	1
MCM2	3	MYPN	7	affinity chromatography technology	Drissi R (2015)	1
NTRK1	1	PUF60	16	affinity chromatography technology	Emdal KB (2015)	1
MYPN	7	TTN	102	two hybrid	Miller MK (2003)	1
CHEK1	2	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference	Yarden RI (2002), Yarden RI (2002), Inoue Y (2007), Shen JP (2017)	4
MAPK1	1	TOP2A	2	pull down, enzymatic study	Shapiro PS (1999), Shapiro PS (1999)	2
NTRK1	1	MCM2	3	affinity chromatography technology	Emdal KB (2015)	1
TRIM63	0	ANKRD1	0	two hybrid, pull down	Witt CC (2008), Witt CC (2008)	2
CDK2	0	ACTN1	5	affinity chromatography technology	Neganova I (2011)	1
TUBA1A	13	SQSTM1	0	affinity chromatography technology	Seiberlich V (2012)	1
GAN	4	TTN	102	affinity chromatography technology	Johnson-Kerner BL (2015)	1
MCM2	3	ACTN1	5	affinity chromatography technology	Drissi R (2015)	1
HSPB2	1	FHL2	0	two hybrid	Grose JH (2015)	1
TOP1	1	CHEK1	2	genetic interference	Srivas R (2016)	1
MCM2	3	FHL2	0	affinity chromatography technology	Drissi R (2015)	1
EWSR1	2	FHL1	1	affinity chromatography technology	Elzi DJ (2014)	1
CDK2	0	CUL4B	8	affinity chromatography technology	Neganova I (2011)	1
GAN	4	CUL3	17	affinity chromatography technology, affinity chromatography technology	Zhang DD (2005), Bennett EJ (2010)	2
EWSR1	2	SRSF2	0	bioid	Elzi DJ (2014)	1
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
CUL3	17	TOP1	1	affinity chromatography technology	Bennett EJ (2010)	1
CDH1	4	PUF60	16	bioid	Guo Z (2014)	1
YWHAQ	0	WEE1	2	pull down	Meek SE (2004)	1
CDK2	0	RBM3	1	affinity chromatography technology	Neganova I (2011)	1
COPS5	0	RBM3	1	affinity chromatography technology	Bennett EJ (2010)	1
LMNA	2	TOP1	1	affinity chromatography technology	Depreux FF (2015)	1
CUL7	4	TTN	102	affinity chromatography technology	Hanson D (2014)	1
CUL3	17	SRPK2	1	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	EWSR1	2	affinity chromatography technology	Tong J (2014)	1
BRCA1	7	FHL2	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Yan J (2003), Yan J (2003), Yan JH (2003), Yan JH (2003), Yan JH (2003), Yan J (2003), Wang J (2011), Hill SJ (2014)	8
MCM2	3	CALM1	0	affinity chromatography technology	Drissi R (2015)	1
ANXA7	0	TTN	102	biochemical	Wan C (2015)	1
COPS5	0	SRSF2	0	affinity chromatography technology	Bennett EJ (2010)	1
FHL2	0	PUF60	16	two hybrid	Gao J (2008)	1
COPS5	0	CDK2	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Chun Y (2013)	2
UBE2A	0	TTN	102	affinity chromatography technology	An H (2017)	1
ANKRD23	1	MYPN	7	two hybrid, two hybrid	Miller MK (2003), Miller MK (2003)	2
BRCA1	7	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2003), Maor S (2007), Maor S (2007), Abramovitch S (2003)	4
VAV2	6	TTN	102	two hybrid	Thalappilly S (2008)	1
NTRK1	1	CUL3	17	affinity chromatography technology	Emdal KB (2015)	1
CAPN3	1	TTN	102	two hybrid, two hybrid	Ono Y (1998), Sorimachi H (1995)	2
TRIM55	2	ANKRD1	0	two hybrid, pull down	Witt CC (2008), Witt CC (2008)	2
NEDD8	0	TTN	102	affinity chromatography technology	Bennett EJ (2010)	1
VAV2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moores SL (2000), Tong J (2009), Duan L (2011), Duan L (2011), Tong J (2008), Tong J (2014)	6
LMNA	2	TTN	102	affinity chromatography technology	Depreux FF (2015)	1
SRPK2	1	CHEK2	2	enzymatic study	Lipp JJ (2015)	1
TOP3A	0	WEE1	2	genetic interference	Srivas R (2016)	1
CUL2	3	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	CPSF6	1	affinity chromatography technology	Emdal KB (2015)	1
CUL3	17	ANK1	8	affinity chromatography technology	Lange S (2012)	1
MAPK1	1	CHEK1	2	biochemical	Wan C (2015)	1
SRPK2	1	CPSF6	1	affinity chromatography technology	Varjosalo M (2013)	1
MAPK1	1	SP1	0	enzymatic study, enzymatic study	Milanini-Mongiat J (2002), Cramer T (2008)	2
PUF60	16	EWSR1	2	affinity chromatography technology	Ewing RM (2007)	1
TRIM63	0	FHL2	0	two hybrid	Witt CC (2008)	1
VAV2	6	SRPK2	1	two hybrid	Thalappilly S (2008)	1
CUL3	17	SRSF2	0	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	ARRB1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
RNF2	1	CALM1	0	affinity chromatography technology	Cao Q (2014)	1
BRCA1	7	CUL2	3	affinity chromatography technology	Ertych N (2016)	1
NTRK1	1	ACTN1	5	affinity chromatography technology	Emdal KB (2015)	1
PUF60	16	TTN	102	affinity chromatography technology	Ewing RM (2007)	1
EGFR	5	YWHAQ	0	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CUL3	17	PUF60	16	affinity chromatography technology	Bennett EJ (2010)	1
CDK2	0	YWHAQ	0	affinity chromatography technology	Neganova I (2011)	1
TCAP	0	ANKRD2	3	affinity chromatography technology, pull down	Kojic S (2004), Kojic S (2004)	2
CUL2	3	RBM3	1	affinity chromatography technology	Bennett EJ (2010)	1
TOP3A	0	CHEK1	2	genetic interference	Srivas R (2016)	1
CUL7	4	MAPK1	1	affinity chromatography technology	Hanson D (2014)	1
HEY1	2	EWSR1	2	affinity chromatography technology	Lopez-Mateo I (2016)	1
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
OBSCN	32	BRCA1	7	two hybrid	Hill SJ (2014)	1
CHEK1	2	MAP2K1	8	genetic interference	Shen JP (2017)	1
BRCA1	7	MCM2	3	affinity chromatography technology	Ertych N (2016)	1
ARRB1	2	CUL3	17	affinity chromatography technology	Skieterska K (2016)	1
ADRB2	0	CALM1	0	affinity chromatography technology	Roy SJ (2013)	1
CDK2	0	NEDD8	0	affinity chromatography technology	Ewing RM (2007)	1
COPS5	0	TOP1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	ANXA7	0	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
ARRB1	2	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
CUL3	17	CPSF6	1	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	TTN	102	affinity chromatography technology	Emdal KB (2015)	1
TCAP	0	TTN	102	two hybrid, enzymatic study, biochemical, two hybrid, pull down, two hybrid, enzymatic study	Gregorio CC (1998), Mayans O (1998), Zou P (2003), Zou P (2003), Mues A (1998), Mues A (1998), Lange S (2005)	7
EGFR	5	CUL4B	8	affinity chromatography technology	Tong J (2014)	1
ANK1	8	TTN	102	two hybrid, pull down	Kontrogianni-Konstantopoulos A (2003), Kontrogianni-Konstantopoulos A (2003)	2
MCM2	3	RBM3	1	affinity chromatography technology	Drissi R (2015)	1
RBM3	1	TTN	102	affinity chromatography technology	Zhu X (2016)	1
BRCA1	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Yan Y (2008), Yan Y (2008)	2
MCM2	3	PUF60	16	affinity chromatography technology	Drissi R (2015)	1
BRCA1	7	CDH1	4	genetic interference	Shen JP (2017)	1
MAPK1	1	MAP2K1	8	affinity chromatography technology, enzymatic study, two hybrid, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, enzymatic study, protein complementation assay, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sanz-Moreno V (2003), Sanz-Moreno V (2003), Robinson FL (2002), Yeung K (2000), Yeung K (2000), Wunderlich W (2001), Xu Be (2001), Xu Be (2001), Chen Z (2001), Srivastav RK (2011), Kubota Y (2011), Ho DT (2003), Wang J (2009), Jahrling JB (2014)	14
CDH1	4	EGFR	5	affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, bioid	Pece S (2000), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Li J (2013), Guo Z (2014)	6
YWHAQ	0	TTN	102	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
TUBA1A	13	WEE1	2	genetic interference	Srivas R (2016)	1
SRPK2	1	SPEN	22	enzymatic study	Lipp JJ (2015)	1
CUL4B	8	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
CHEK1	2	TTN	102	genetic interference	Srivas R (2016)	1
SP1	0	FHL1	1	affinity chromatography technology	Chuang JY (2012)	1
ANKRD1	0	MYPN	7	two hybrid, two hybrid, two hybrid, pull down	Miller MK (2003), Miller MK (2003), Bang ML (2001), Bang ML (2001)	4
SQSTM1	0	CUL3	17	imaging technique, affinity chromatography technology	Lau A (2010), Mori Y (2015)	2
ADRB2	0	CUL2	3	affinity chromatography technology	Xie L (2009)	1
EGFR	5	SRSF2	0	affinity chromatography technology	Yao Z (2017)	1
TTN	102	ANKRD1	0	two hybrid, pull down, two hybrid	Miller MK (2003), Miller MK (2003), Miller MK (2003)	3
RNF2	1	CDH1	4	affinity chromatography technology	Cao Q (2014)	1
CDK2	0	SP1	0	enzymatic study	Fojas de Borja P (2001)	1
NTRK1	1	TOP1	1	affinity chromatography technology	Emdal KB (2015)	1
TLE3	2	TTN	102	affinity chromatography technology	Huttlin EL (2017)	1
CUL2	3	SRSF2	0	affinity chromatography technology	Bennett EJ (2010)	1
GAN	4	TUBA1A	13	affinity chromatography technology	Johnson-Kerner BL (2015)	1
EGFR	5	LMNA	2	affinity chromatography technology	Liccardi G (2014)	1
SRPK2	1	TOP1	1	enzymatic study	Lipp JJ (2015)	1
TOP1	1	TTN	102	genetic interference	Srivas R (2016)	1
CRYAB	0	CDH1	4	affinity chromatography technology	Huang Z (2012)	1
NTRK1	1	CDK2	0	affinity chromatography technology	Emdal KB (2015)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
ANXA7	0	TUBA1A	13	two hybrid	Vinayagam A (2011)	1
SQSTM1	0	NTRK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wooten MW (2001), Geetha T (2003), Jadhav T (2008), Wooten MW (2008), Wooten MW (2008), Zheng C (2015)	6
COPS5	0	TTN	102	affinity chromatography technology	Bennett EJ (2010)	1
CHEK2	2	BRCA1	7	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Lee JS (2000), Lee JS (2000), Chabalier-Taste C (2008), Chabalier-Taste C (2008), Liu Y (2002), Inoue Y (2007), Dutta D (2015), Dutta D (2015)	8
CUL4B	8	TTN	102	affinity chromatography technology	Bennett EJ (2010)	1
TUBA1A	13	CHEK1	2	genetic interference	Srivas R (2016)	1
CDK2	0	TOP1	1	affinity chromatography technology	Neganova I (2011)	1
LMNA	2	CPSF6	1	bioid	Roux KJ (2012)	1
WEE1	2	TTN	102	genetic interference	Srivas R (2016)	1
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
TTN	102	CALM1	0	affinity chromatography technology	Gautel M (1995)	1
EGFR	5	TUBA1A	13	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
SRSF2	0	TTN	102	biochemical	Havugimana PC (2012)	1
RNF2	1	TOP2A	2	affinity chromatography technology	Hein MY (2015)	1
CDK2	0	TTN	102	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), So J (2015)	2
FHL2	0	FHL1	1	pull down	Lange S (2002)	1
BRCA1	7	TOP1	1	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Shen JP (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017)	7
CHEK1	2	WEE1	2	genetic interference, genetic interference	Srivas R (2016), Srivas R (2016)	2
FHL1	1	TTN	102	two hybrid, two hybrid	Raskin A (2012), Raskin A (2012)	2
CUL7	4	YWHAQ	0	affinity chromatography technology	Hanson D (2014)	1
MAPK1	1	CHEK2	2	biochemical	Wan C (2015)	1
WEE1	2	MCM2	3	affinity chromatography technology	Boldt K (2016)	1
SQSTM1	0	MAPK1	1	affinity chromatography technology	Linares JF (2011)	1
TRIM55	2	FHL2	0	two hybrid	Witt CC (2008)	1
EGFR	5	SPEN	22	affinity chromatography technology	Yao Z (2017)	1
BRCA1	7	TOP2A	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lou Z (2005), Lou Z (2005), Lou Z (2005), Hill SJ (2014)	4
CUL2	3	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	YWHAQ	0	affinity chromatography technology	Bennett EJ (2010)	1
SRPK2	1	LMNA	2	enzymatic study	Lipp JJ (2015)	1
CALM1	0	NBR1	0	pull down	Shen X (2005)	1
ACTN1	5	TUBA1A	13	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Cerecedo D (2008), Cerecedo D (2008), Cerecedo D (2008)	3
TTN	102	ANKRD23	1	two hybrid, pull down, two hybrid	Miller MK (2003), Miller MK (2003), Miller MK (2003)	3
TOP2A	2	TTN	102	genetic interference	Srivas R (2016)	1
CUL3	17	YWHAQ	0	affinity chromatography technology	Bennett EJ (2010)	1
TRIM63	0	TCAP	0	two hybrid, two hybrid	Witt SH (2005), Witt CC (2008)	2
RAPGEF2	5	TTN	102	affinity chromatography technology	Kim TY (2014)	1
MAP2K1	8	TTN	102	genetic interference	Srivas R (2016)	1
HEY1	2	TUBA1A	13	affinity chromatography technology	Lopez-Mateo I (2016)	1
CDH1	4	ACTN1	5	affinity chromatography technology	Hazan RB (1998)	1
SPEN	22	TTN	102	biochemical	Havugimana PC (2012)	1
CRYAB	0	HSPB2	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, two hybrid	Sugiyama Y (2000), Sugiyama Y (2000), Fu L (2003), Fu L (2003), Delbecq SP (2012), Aquilina JA (2013), Grose JH (2015)	7
TRIM55	2	MYBPC3	2	two hybrid	Witt CC (2008)	1
EWSR1	2	CPSF6	1	two hybrid	Rual JF (2005)	1
NTRK1	1	CUL4B	8	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	YWHAQ	0	affinity chromatography technology	Emdal KB (2015)	1
SRPK2	1	TTN	102	enzymatic study	Varjosalo M (2013)	1
CUL4B	8	CALM1	0	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	LMNA	2	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	TTN	102	affinity chromatography technology	Yao Z (2017)	1
TSC22D2	2	TTN	102	two hybrid	Li Q (2016)	1
EWSR1	2	CALM1	0	pull down	Deloulme JC (1997)	1
MAPK1	1	TTN	102	enzymatic study, genetic interference	Raskin A (2012), Srivas R (2016)	2
TOP2A	2	CHEK1	2	genetic interference	Srivas R (2016)	1
CDK2	0	UBE2A	0	enzymatic study	Sarcevic B (2002)	1
NEDD8	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
CUL4B	8	TLE3	2	affinity chromatography technology	Higa LA (2006)	1
CUL3	17	TUBA1A	13	affinity chromatography technology	Bennett EJ (2010)	1
TTN	102	SQSTM1	0	enzymatic study	Lange S (2005)	1
NEDD8	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
TSC22D2	2	RNF2	1	two hybrid	Li Q (2016)	1
ADRB2	0	TTN	102	affinity chromatography technology	Roy SJ (2013)	1
COPS5	0	CHEK1	2	affinity chromatography technology	Bennett EJ (2010)	1
CDK2	0	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Ruffner H (1999), Ruffner H (1999), Ruffner H (1999), Wang H (1997), Chen Y (1996)	5
CUL3	17	CALM1	0	affinity chromatography technology	Bennett EJ (2010)	1
HSPB2	1	TCAP	0	two hybrid	Grose JH (2015)	1
EGFR	5	CALM1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, pull down	Li H (2004), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Aifa S (2002)	5
CUL7	4	CPSF6	1	affinity chromatography technology	Hanson D (2014)	1
TOP2A	2	CUL2	3	affinity chromatography technology	Yun J (2009)	1
CUL7	4	SPEN	22	affinity chromatography technology	Hanson D (2014)	1
NTRK1	1	CUL2	3	affinity chromatography technology	Emdal KB (2015)	1
CDK2	0	PUF60	16	affinity chromatography technology	Neganova I (2011)	1
DYRK2	1	TTN	102	affinity chromatography technology	Varjosalo M (2013)	1
ASF1B	0	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jasencakova Z (2010), Campos EI (2015), Drissi R (2015), Huttlin EL (2017)	4
ACTN1	5	TTN	102	pull down, two hybrid, pull down, affinity chromatography technology	Joseph C (2001), Young P (1998), Young P (1998), Young P (1998)	4
BRCA1	7	YWHAQ	0	affinity chromatography technology	Ertych N (2016)	1
NTRK1	1	TUBA1A	13	affinity chromatography technology	Emdal KB (2015)	1
HSPB2	1	TTN	102	two hybrid	Grose JH (2015)	1
COPS5	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), He F (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
CUL7	4	EWSR1	2	affinity chromatography technology	Hanson D (2014)	1
CUL3	17	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	TLE3	2	affinity chromatography technology	Emdal KB (2015)	1
BRCA1	7	WEE1	2	genetic interference	Shen JP (2017)	1
CHEK2	2	TTN	102	genetic interference	Srivas R (2016)	1
CDH1	4	LMNA	2	affinity chromatography technology	Catimel B (2005)	1
ALB	1	TTN	102	affinity chromatography technology	Zhou M (2004)	1
RAPGEF2	5	LMNA	2	affinity chromatography technology	Kim TY (2014)	1
NTRK1	1	MAPK1	1	affinity chromatography technology	Emdal KB (2015)	1
SP1	0	CALM1	0	affinity chromatography technology	Chuang JY (2012)	1
EWSR1	2	TTN	102	bioid	Elzi DJ (2014)	1
MYBPC3	2	TRIM63	0	two hybrid, two hybrid	Mearini G (2010), Witt CC (2008)	2
TTN	102	MYBPC3	2	far western blotting	Freiburg A (1996)	1
CUL7	4	LMNA	2	affinity chromatography technology	Hanson D (2014)	1
HSPB2	1	MYBPC3	2	two hybrid	Grose JH (2015)	1
SQSTM1	0	TRIM63	0	two hybrid, two hybrid	Lange S (2005), Witt CC (2008)	2
FHL2	0	TTN	102	two hybrid, pull down	Lange S (2002), Lange S (2002)	2
TUBA1A	13	TTN	102	genetic interference	Srivas R (2016)	1
NEDD8	0	SRSF2	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
YWHAQ	0	CALM1	0	affinity chromatography technology, pull down, biochemical	Pozuelo-Rubio M (2010), Meek SE (2004), Pozuelo-Rubio M (2010)	3
COPS5	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Pick E (2012)	7
ARRB1	2	TTN	102	affinity chromatography technology	Xiao K (2007)	1
MCM2	3	LMNA	2	affinity chromatography technology	Drissi R (2015)	1
NTRK1	1	VAV2	6	affinity chromatography technology	Emdal KB (2015)	1
YWHAQ	0	TUBA1A	13	pull down	Meek SE (2004)	1