PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2E1	1	RNF115	1	two hybrid	van Wijk SJ (2009)	1
UBE2I	0	RNF40	11	two hybrid	Rolland T (2014)	1
LRSAM1	2	RNF111	2	two hybrid	Woodsmith J (2012)	1
RNF26	2	EPS15	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Jongsma ML (2016), Jongsma ML (2016), Jongsma ML (2016)	3
RNF2	1	RNF114	0	affinity chromatography technology	Cao Q (2014)	1
UBE2E1	1	UBOX5	4	two hybrid	Markson G (2009)	1
UBE3A	4	JADE1	6	two hybrid, two hybrid, two hybrid	Vinayagam A (2011), Lim J (2006), Corominas R (2014)	3
TRIM33	4	UBE2E1	1	pull down	Weng L (2014)	1
USP7	14	WWP2	7	two hybrid, affinity chromatography technology	Lim J (2006), Chaudhary N (2014)	2
UBE2I	0	RNF10	0	two hybrid	Markson G (2009)	1
TRIM23	3	POLL	3	two hybrid	Rolland T (2014)	1
DTX3L	1	RNF111	2	two hybrid	Woodsmith J (2012)	1
RNF11	0	EPS15	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2004), Kostaras E (2012), Kostaras E (2014)	3
UBE2I	0	TRAF6	0	enzymatic study, enzymatic study	Li Y (2013), Pham LV (2008)	2
BRCA1	7	XIAP	0	affinity chromatography technology, pull down	Martin SA (2005), Martin SA (2005)	2
UBE2E1	1	ZNF827	2	biochemical	Havugimana PC (2012)	1
UBE2E1	1	UBASH3B	4	enzymatic study	Hoeller D (2007)	1
TRIM28	1	UBE2E1	1	pull down	Doyle JM (2010)	1
BRCA1	7	H2AFY	1	imaging technique	Ganesan S (2002)	1
ATXN1	2	TRIM32	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
UBE2E1	1	CUL3	17	pull down	Plafker KS (2009)	1
STUB1	4	UBE2E1	1	pull down, pull down	Soss SE (2011), Parsons JL (2009)	2
UBE2E1	1	RING1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Markson G (2009), Wheaton K (2017), Wheaton K (2017)	3
TRAF6	0	MARCH5	0	affinity chromatography technology	Shi HX (2011)	1
UBE2E1	1	RNF166	0	two hybrid	Markson G (2009)	1
BRCA1	7	UBE2I	0	fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Morris JR (2009), Morris JR (2009), Xu J (2009), Xu J (2009)	4
UBE2E1	1	RELA	1	enzymatic study	Ryo A (2003)	1
PRKN	1	FBXO7	1	affinity chromatography technology, pull down, pull down	Burchell VS (2013), Burchell VS (2013), Burchell VS (2013)	3
CNOT4	4	UBE2E1	1	two hybrid, two hybrid	Winkler GS (2004), Albert TK (2002)	2
PRKN	1	EPS15	1	pull down, enzymatic study	Fallon L (2006), Fallon L (2006)	2
TRIM7	2	UBE2E1	1	two hybrid	Napolitano LM (2011)	1
UBE2E1	1	RFWD3	5	two hybrid	Markson G (2009)	1
RNF166	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chen HW (2015), Chen HW (2015)	2
CUL3	17	TRIM3	2	affinity chromatography technology	Wimuttisuk W (2014)	1
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
MAP3K1	4	RNF114	0	enzymatic study	Charlaftis N (2014)	1
PCGF5	1	RING1	2	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Woodsmith J (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
UBE2E1	1	UFM1	0	two hybrid	van Wijk SJ (2009)	1
UBE2E1	1	ZNRF4	1	two hybrid	van Wijk SJ (2009)	1
BRCA1	7	RELA	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Benezra M (2003), Benezra M (2003), Benezra M (2003), Volcic M (2012)	4
MID2	1	UBE2E1	1	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
ARIH2	4	TRIM27	2	two hybrid	Woodsmith J (2012)	1
RNF2	1	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
RNF13	0	RNF167	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2E1	1	RNF181	0	two hybrid, pull down	van Wijk SJ (2009), Pedersen SM (2015)	2
MKRN3	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
UBE2E1	1	PAEP	1	two hybrid	Stelzl U (2005)	1
CUL3	17	USP7	14	affinity chromatography technology	Bennett EJ (2010)	1
TRAF6	0	UBOX5	4	two hybrid	Woodsmith J (2012)	1
BIRC7	0	UBE2E1	1	two hybrid	Dynek JN (2010)	1
NHLRC1	3	UBE2E1	1	pull down	Gentry MS (2005)	1
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
UBE2E1	1	LRSAM1	2	two hybrid	Markson G (2009)	1
ZNF827	2	BRCA1	7	imaging technique	Conomos D (2014)	1
HDAC6	0	STUB1	4	affinity chromatography technology	Cook C (2012)	1
RNF2	1	RELA	1	affinity chromatography technology	Cao Q (2014)	1
TRIM17	5	LRSAM1	2	two hybrid	Woodsmith J (2012)	1
TRIM50	1	UBE2E1	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
UBE2E1	1	TRIM39	0	two hybrid, pull down	Markson G (2009), Woodsmith J (2012)	2
ATXN1	2	DZIP3	6	two hybrid, affinity chromatography technology, enzymatic study	Lim J (2006), Yoon JH (2013), Yoon JH (2013)	3
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
RNF11	0	USP7	14	affinity chromatography technology	Poulsen SL (2013)	1
USP7	14	TRAF6	0	pull down, affinity chromatography technology, enzymatic study	Zapata JM (2001), Daubeuf S (2009), Bremm A (2010)	3
TRIM29	2	TRIM23	3	two hybrid, two hybrid, two hybrid	Reymond A (2001), Reymond A (2001), Rolland T (2014)	3
UBE2I	0	UBE2E1	1	biochemical	Wan C (2015)	1
DTX3	4	CHFR	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATXN1	2	USP7	14	two hybrid, affinity chromatography technology	Hong S (2002), Hong S (2002)	2
UBE2E1	1	RNF14	2	two hybrid, two hybrid, pull down	Ito K (2001), Markson G (2009), Ito K (2001)	3
MAP3K1	4	UBASH3B	4	enzymatic study	Charlaftis N (2014)	1
BRCA1	7	UBE3A	4	pull down	Wu-Baer F (2003)	1
UBE3A	4	UBE2E1	1	pull down, two hybrid, pull down	Nuber U (1996), Kumar S (1997), Kumar S (1997)	3
BRCA1	7	UBA1	1	affinity chromatography technology	Ertych N (2016)	1
USP7	14	MARCH7	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Hayes SD (2012), Nathan JA (2008), Zhang L (2016)	4
RNF169	1	UBE2E1	1	pull down	Poulsen M (2012)	1
JADE1	6	UBE2E1	1	pull down	Chitalia VC (2008)	1
UBE2I	0	DTX3L	1	two hybrid	Markson G (2009)	1
UBE2E1	1	RNF13	0	two hybrid	van Wijk SJ (2009)	1
USP7	14	RNF168	0	pull down, affinity chromatography technology	Zhu Q (2015), Zhu Q (2015)	2
RNF111	2	MARCH7	0	two hybrid	Woodsmith J (2012)	1
UBE2E1	1	PAF1	6	affinity chromatography technology, affinity chromatography technology	Zhu B (2005), Zhu B (2005)	2
RNF8	2	BARD1	4	affinity chromatography technology	Yang Q (2016)	1
UBE2E1	1	RNF5	0	two hybrid	Markson G (2009)	1
UBE2I	0	RNF111	2	two hybrid, two hybrid, two hybrid	Markson G (2009), Bandyopadhyay S (2010), Rolland T (2014)	3
UBE2E1	1	ZNRF1	1	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Markson G (2009)	3
DTX3	4	RNF114	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC8	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ID2	0	UBE2E1	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE3A	4	IPO11	0	biochemical	Kristensen AR (2012)	1
UBE2E1	1	RNF111	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
UBE2E1	1	RNF26	2	two hybrid	Markson G (2009)	1
ATXN1	2	UBE2I	0	two hybrid	Lim J (2006)	1
RING1	2	RNF2	1	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Gearhart MD (2006), Wang H (2004), Trojer P (2011), Gao Z (2012), Gao Z (2012), Cao Q (2014), Hein MY (2015)	8
UBE2E1	1	POLM	5	enzymatic study	Hoeller D (2007)	1
BRCA1	7	UBE2E1	1	two hybrid, x-ray crystallography, pull down, two hybrid, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011)	5
UBE2I	0	CHFR	5	enzymatic study	Kwon YE (2013)	1
UBE2E1	1	RNF4	1	two hybrid, pull down	Markson G (2009), Banka PA (2015)	2
UBE2E1	1	ARIH2	4	two hybrid	Markson G (2009)	1
RNF103	1	UBE2E1	1	two hybrid	Scheper J (2009)	1
XIAP	0	UBE2E1	1	two hybrid, pull down	Dynek JN (2010), Markson G (2009)	2
USP7	14	RNF2	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maertens GN (2010), Maertens GN (2010), de Bie P (2010), de Bie P (2010), de Bie P (2010), de Bie P (2010), de Bie P (2010), Gao Z (2012), Cao Q (2014), Lecona E (2015), Lecona E (2015), Hein MY (2015)	12
USP8	7	RNF128	1	affinity chromatography technology	Soares L (2004)	1
RNF5	0	RNF185	1	two hybrid	Rolland T (2014)	1
BARD1	4	UBE2E1	1	pull down	David Y (2011)	1
USP8	7	UBE2E1	1	biochemical	Wan C (2015)	1
UBE2E1	1	LEO1	3	affinity chromatography technology	Zhu B (2005)	1
CUL3	17	TRIM28	1	affinity chromatography technology	Bennett EJ (2010)	1
WWP2	7	UBE2E1	1	pull down	Xu H (2009)	1
TRIB1	1	UBE2E1	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2E1	1	RNF114	0	two hybrid, enzymatic study	Markson G (2009), Lin B (2017)	2
TOPORS	6	UBE2I	0	two hybrid, pull down	Weger S (2003), Weger S (2005)	2
PRKN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Imai Y (2003), Zhu X (2017)	5
UBE2I	0	TRIM29	2	two hybrid	Rual JF (2005)	1
NEDD4L	3	H1F0	3	pull down	Persaud A (2009)	1
ZNRF2	0	UBE2E1	1	two hybrid	Scheper J (2009)	1
TRIM38	3	TRAF6	0	affinity chromatography technology	Zhao W (2012)	1
UBE2E1	1	RNF2	1	two hybrid, affinity chromatography technology, pull down	Markson G (2009), Wheaton K (2017), Wheaton K (2017)	3
UBE2E1	1	NEDD4	2	enzymatic study, pull down, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, pull down	Anan T (1998), Malakhova OA (2008), Malakhova OA (2008), Woelk T (2006), Sarkari F (2013), Sarkari F (2013), Sugeno N (2014), Zhang X (2017)	8
UBE2I	0	MAP3K1	4	two hybrid, pull down, affinity chromatography technology	Saltzman A (1998), Saltzman A (1998), Kubota Y (2011)	3
RNF168	0	H2AFZ	1	enzymatic study	OConnor HF (2015)	1
TRIM23	3	UBE2E1	1	pull down, pull down, pull down, enzymatic study, pull down	Ko JA (2006), Vichi A (2005), Vichi A (2006), Vichi A (2005), Dawidziak DM (2017)	5
MARCH7	0	UBE2E1	1	pull down	Flach K (2014)	1
TRIM37	7	UBE2E1	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
USP7	14	RNF169	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Hein MY (2015), An L (2017), An L (2017), An L (2017), An L (2017), An L (2017)	6
UBE2E1	1	220869	0	two hybrid	Stelzl U (2005)	1
UBE2E1	1	RNF167	2	two hybrid, pull down	van Wijk SJ (2009), Yamada HY (2006)	2
DTL	0	UBE2E1	1	affinity chromatography technology	Shibata E (2011)	1
UBE2E1	1	DDA1	1	affinity chromatography technology	Pick E (2007)	1
LEO1	3	PAF1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology	Rozenblatt-Rosen O (2005), Nordick K (2008), Nordick K (2008), Nordick K (2008), Kim J (2010), Mak AB (2010), Mak AB (2010), Takahashi A (2011), Havugimana PC (2012), Rolland T (2014), Wan C (2015), Hein MY (2015)	12
ZNRF2	0	ZNRF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hoxhaj G (2012), Hoxhaj G (2012), Hoxhaj G (2012), Hoxhaj G (2012)	4
TRIM27	2	MID2	1	two hybrid	Rolland T (2014)	1
UBE2E1	1	MID1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Du H (2014)	5
TRIB2	2	UBE2E1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM28	1	TRIM23	3	biochemical	Reymond A (2001)	1
UBE2E1	1	CADPS2	0	two hybrid	van Wijk SJ (2009)	1
MBD5	14	UBE2E1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2E1	1	RNF10	0	two hybrid	Markson G (2009)	1
RNF115	1	UBE2I	0	two hybrid, pull down	Amemiya Y (2008), Colomer-Lluch M (2017)	2
MGRN1	4	ITCH	1	affinity chromatography technology	Gunn TM (2012)	1
PAF1	6	RNF20	9	affinity chromatography technology, biochemical, biochemical, pull down	Zhu B (2005), Wu L (2014), Wu L (2014), Wu L (2014)	4
RNF11	0	NEDD4L	3	two hybrid	Colland F (2004)	1
CUL3	17	UBA1	1	affinity chromatography technology	Bennett EJ (2010)	1
UBE2E1	1	UBE2E1	1	enzymatic study, enzymatic study	David Y (2010), Banka PA (2015)	2
MID2	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
LEO1	3	CTR9	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rozenblatt-Rosen O (2005), Nordick K (2008), Nordick K (2008), Kim J (2010), Mak AB (2010), Mak AB (2010), Ouna BA (2012), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Hein MY (2015), Boldt K (2016)	12
TRIM17	5	UBE2E1	1	two hybrid	Napolitano LM (2011)	1
STUB1	4	RELA	1	affinity chromatography technology	Wang S (2012)	1
FBXO7	1	H1F0	3	enzymatic study	Teixeira FR (2016)	1
TRIM32	2	MID2	1	two hybrid	Reymond A (2001)	1
RNF4	1	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay	Bruderer R (2011), Kuo CY (2014), Kuo CY (2014), Kuo CY (2014), Kuo CY (2014)	5
RNF11	0	NEDD4	2	affinity chromatography technology, enzymatic study, two hybrid	Santonico E (2010), Persaud A (2009), Colland F (2004)	3
CUL3	17	TRIM33	4	affinity chromatography technology	Bennett EJ (2010)	1
DTX3L	1	ITCH	1	affinity chromatography technology, pull down, pull down	Holleman J (2014), Holleman J (2014), Holleman J (2014)	3
FBXO7	1	RNF181	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF128	1	OTUB1	0	two hybrid, affinity chromatography technology, pull down	Soares L (2004), Soares L (2004), Soares L (2004)	3
TRIM32	2	TRIM27	2	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
UBA1	1	UBE2E1	1	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Nuber U (1996), Takeuchi T (2005), Wauer T (2015), Huguenin-Dezot N (2016)	6
UBE2I	0	DTL	0	affinity chromatography technology	Hein MY (2015)	1
MGRN1	4	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Gunn TM (2012), Gunn TM (2012)	2
RNF11	0	RNF168	0	two hybrid	Colland F (2004)	1
RNF20	9	RNF40	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Zhang F (2011), Jaeaeskelaeinen T (2011), Jaeaeskelaeinen T (2011), Moyal L (2011), Moyal L (2011), Zhu B (2005), Kim J (2009), Bedi U (2015), Klement K (2014), Duan Y (2016), Duan Y (2016), Foglizzo M (2016)	12
FBXO7	1	UBE2E1	1	pull down	Teixeira FR (2016)	1
TRIB2	2	DET1	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM17	5	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Woodsmith J (2012), Rolland T (2014)	3
FBXO2	0	UBE2E1	1	pull down	Nelson RF (2006)	1
UBE2E1	1	RNF130	0	two hybrid, pull down	van Wijk SJ (2009), Guais A (2006)	2
TRIM23	3	UBOX5	4	two hybrid	Woodsmith J (2012)	1
UBE2E1	1	RNF150	2	two hybrid	van Wijk SJ (2009)	1
UBE2E1	1	RNF11	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
RNF2	1	SIK1	0	affinity chromatography technology, affinity chromatography technology, pull down	Qu C (2017), Qu C (2017), Qu C (2017)	3
UBE2E1	1	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
BARD1	4	UBE3A	4	pull down	Wu-Baer F (2003)	1
UBE2I	0	RNF4	1	two hybrid, two hybrid	Markson G (2009), Bandyopadhyay S (2010)	2
UBE2E1	1	H2AFY	1	affinity chromatography technology	Wheaton K (2017)	1
PRKN	1	UBE2E1	1	pull down, pull down	Shin JH (2011), Kazlauskaite A (2014)	2
TRIM45	1	UBE2E1	1	two hybrid	Napolitano LM (2011)	1
BRCA1	7	TRIM28	1	affinity chromatography technology	Ertych N (2016)	1
RNF2	1	OTUB1	0	affinity chromatography technology	Cao Q (2014)	1
UBE2E1	1	EPS15	1	enzymatic study	Hoeller D (2007)	1
PRKN	1	UBASH3B	4	pull down	Ikeda F (2007)	1
NEDD4	2	EPS15	1	enzymatic study	Woelk T (2006)	1
UBE2I	0	WWP2	7	enzymatic study	Bawa-Khalfe T (2016)	1
TRIM27	2	TRIM11	1	two hybrid	Reymond A (2001)	1
USP8	7	OTUB1	0	affinity chromatography technology	Soares L (2004)	1
UBE2E1	1	RNF8	2	two hybrid, pull down	Ito K (2001), Ito K (2001)	2
CUL3	17	ITCH	1	affinity chromatography technology	Bennett EJ (2010)	1
ATXN1	2	STUB1	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Al-Ramahi I (2006), Al-Ramahi I (2006), Choi JY (2007), Choi JY (2007)	4
TRIM33	4	UBE2I	0	affinity chromatography technology, affinity chromatography technology	Fattet L (2013), Ikeuchi Y (2014)	2
UBE2I	0	TRIM23	3	two hybrid, two hybrid, two hybrid	Markson G (2009), Rolland T (2014), Yu H (2011)	3
TRAF6	0	UBE2E1	1	pull down	Markson G (2009)	1
BIRC7	0	UBE2I	0	two hybrid, two hybrid	Dynek JN (2010), Dynek JN (2010)	2
PCGF5	1	RNF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Woodsmith J (2012), Woodsmith J (2012), Cao Q (2014), Huttlin EL (2015), Gao Z (2014), Gao Z (2014), Taherbhoy AM (2015), Taherbhoy AM (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	13
TOPORS	6	UBE2E1	1	pull down	Rajendra R (2004)	1
UBE2E1	1	DTX3	4	two hybrid	Markson G (2009)	1
TRIM29	2	TRIM27	2	two hybrid, affinity chromatography technology	Reymond A (2001), Hein MY (2015)	2
RNF11	0	WWP2	7	two hybrid	Colland F (2004)	1
MID1	1	MID2	1	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reymond A (2001), Reymond A (2001), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2006), Short KM (2006), Rolland T (2014), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016)	13
UBE2E1	1	BIRC8	0	two hybrid	Markson G (2009)	1
TRIM3	2	UBE2E1	1	pull down	Raheja R (2014)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
RNF166	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM50	1	HDAC6	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Fusco C (2012), Fusco C (2014), Fusco C (2014)	3
RNF122	0	UBE2E1	1	pull down	Peng Z (2010)	1
UBE2E1	1	RNF25	1	two hybrid, two hybrid, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Huttlin EL (2017)	3
STUB1	4	NHLRC1	3	affinity chromatography technology, affinity chromatography technology	Rao SN (2010), Sengupta S (2011)	2
CHFR	5	RELA	1	affinity chromatography technology, affinity chromatography technology	Kashima L (2009), Kashima L (2009)	2
UBE2E1	1	TRIM2	1	two hybrid	Markson G (2009)	1
DTX1	2	DTX3L	1	affinity chromatography technology	Takeyama K (2003)	1
ATXN1	2	UBE2E1	1	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hong S (2008), Hong S (2008), Hong S (2008), Hong S (2008), Hong S (2008), Kang AR (2015)	6
DET1	2	UBE2E1	1	affinity chromatography technology, affinity chromatography technology	Pick E (2007), Huttlin EL (2017)	2
XIAP	0	UBE2I	0	two hybrid, two hybrid	Dynek JN (2010), Dynek JN (2010)	2
IPO11	0	UBE2E1	1	two hybrid, pull down, pull down, pull down	Plafker SM (2000), Plafker SM (2000), Plafker SM (2000), Plafker SM (2004)	4
UBE2E1	1	CHFR	5	two hybrid	Markson G (2009)	1
BRCA1	7	USP7	14	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
UBE3A	4	RNF2	1	enzymatic study, affinity chromatography technology, pull down, enzymatic study	Zaaroor-Regev D (2010), Zaaroor-Regev D (2010), Zaaroor-Regev D (2010), Mortensen F (2015)	4
UBE2I	0	RNF128	1	two hybrid	Markson G (2009)	1
RELA	1	USP7	14	affinity chromatography technology, affinity chromatography technology, enzymatic study	Colleran A (2013), Colleran A (2013), Colleran A (2013)	3
DDA1	1	DTL	0	affinity chromatography technology	Olma MH (2009)	1
UBE2I	0	RNF185	1	two hybrid	Markson G (2009)	1
UBE2E1	1	PCGF5	1	affinity chromatography technology	Wheaton K (2017)	1
TRIM38	3	UBE2E1	1	two hybrid	Napolitano LM (2011)	1
UBE2E1	1	F12	0	pull down	Koh MY (2008)	1
RNF40	11	PAF1	6	biochemical, biochemical	Wu L (2014), Wu L (2014)	2
TRAF6	0	ITCH	1	affinity chromatography technology	Shembade N (2008)	1
UBE2E1	1	MUL1	1	two hybrid, pull down	van Wijk SJ (2009), Ni G (2017)	2
TRAF6	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
TRIM11	1	UBE2E1	1	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
UBE2E1	1	DTX1	2	two hybrid	van Wijk SJ (2009)	1
TRIB1	1	DET1	2	affinity chromatography technology	Huttlin EL (2017)	1
RNF2	1	TRIM28	1	affinity chromatography technology	Cao Q (2014)	1
HDAC6	0	RELA	1	affinity chromatography technology	Yang CJ (2015)	1
UBASH3B	4	CUL3	17	pull down	Krupina K (2016)	1
UBA7	2	UBE2E1	1	enzymatic study	Takeuchi T (2005)	1
USP7	14	RING1	2	affinity chromatography technology, pull down, affinity chromatography technology	Maertens GN (2010), de Bie P (2010), Hein MY (2015)	3
ITCH	1	HDAC6	0	affinity chromatography technology	OConnor HF (2015)	1
UBE2E1	1	MARCH3	0	two hybrid	Markson G (2009)	1
RNF40	11	UBE2E1	1	pull down	Zhu B (2005)	1
XIAP	0	DTX3	4	two hybrid	Woodsmith J (2012)	1
UBE2E1	1	RNF43	5	two hybrid	van Wijk SJ (2009)	1
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
UBE2E1	1	HDAC6	0	enzymatic study	Hoeller D (2007)	1
RNF128	1	UBE2E1	1	pull down	Anandasabapathy N (2003)	1
CUL3	17	H2AFY	1	affinity chromatography technology	Hernandez-Munoz I (2005)	1
TRIM37	7	TRAF6	0	pull down	Zapata JM (2001)	1
OTUB1	0	STUB1	4	affinity chromatography technology	Scholz CC (2016)	1
SIK1	0	UBE2E1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM29	2	TRIM11	1	two hybrid	Reymond A (2001)	1
FBXO7	1	MBD5	14	enzymatic study	Teixeira FR (2016)	1
TRIM2	1	TRIM3	2	affinity chromatography technology	Huttlin EL (2017)	1
RNF25	1	TRIM27	2	two hybrid	Woodsmith J (2012)	1
TRIM29	2	UBE2E1	1	pull down	Xing J (2016)	1
UBE2E1	1	H2AFZ	1	affinity chromatography technology	Wheaton K (2017)	1
UBE2E1	1	DTX3L	1	two hybrid	Markson G (2009)	1
UBE2E1	1	POLL	3	enzymatic study	Hoeller D (2007)	1
UBE2E1	1	RNF165	0	two hybrid	van Wijk SJ (2009)	1
DTX1	2	MAP3K1	4	affinity chromatography technology, pull down	Liu WH (2005), Liu WH (2005)	2
MARCH5	0	UBE2E1	1	pull down	Nakamura N (2006)	1
BARD1	4	RELA	1	affinity chromatography technology	Benezra M (2003)	1
RNF168	0	UBE2E1	1	pull down	Poulsen M (2012)	1
UBE2E1	1	RNF185	1	two hybrid	Markson G (2009)	1
UBE2I	0	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2I	0	USP8	7	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TOPORS	6	TRIM28	1	affinity chromatography technology	Pungaliya P (2007)	1
NEDD4	2	UBOX5	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
UBE2E1	1	RNF20	9	affinity chromatography technology, affinity chromatography technology, pull down	Zhu B (2005), Zhu B (2005), Zhu B (2005)	3
XIAP	0	TRIM32	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ryu YS (2011), Ryu YS (2011), Ryu YS (2011)	3
TRIM32	2	UBE2E1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Locke M (2009), Albor A (2006)	5
PRKN	1	H1F0	3	affinity chromatography technology	Zanon A (2013)	1
ITCH	1	UBA1	1	affinity chromatography technology	OConnor HF (2015)	1
ATXN1	2	LRSAM1	2	two hybrid	Lim J (2006)	1
TRIM32	2	TRIM23	3	two hybrid	Reymond A (2001)	1
UBE2E1	1	RLIM	1	two hybrid	Markson G (2009)	1
TRIM29	2	MID2	1	two hybrid	Reymond A (2001)	1
MUL1	1	UBE2I	0	affinity chromatography technology	Braschi E (2009)	1
UBE2E1	1	RNF152	0	two hybrid	van Wijk SJ (2009)	1
BRCA1	7	RNF169	1	affinity chromatography technology	Hill SJ (2014)	1
DET1	2	RNF14	2	affinity chromatography technology	Pick E (2007)	1
RNF166	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
DET1	2	DDA1	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pick E (2007), Pick E (2007), Pick E (2007), Olma MH (2009), Pick E (2007), Huttlin EL (2017)	6
UBE2E1	1	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2I	0	TRIM28	1	affinity chromatography technology, pull down, enzymatic study, pull down	Liang Q (2011), Garvin AJ (2013), Ivanov AV (2007), Neo SH (2015)	4
HDAC6	0	TRIM27	2	affinity chromatography technology	Joshi P (2013)	1
BIRC7	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oberoi-Khanuja TK (2012), Oberoi-Khanuja TK (2012), Huttlin EL (2015), Huttlin EL (2017)	4
UBE2E1	1	DZIP3	6	two hybrid	Markson G (2009)	1
ITCH	1	RNF11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Santonico E (2010), Pranski EL (2012), Kitching R (2003)	4
UBE2E1	1	CTR9	10	affinity chromatography technology	Zhu B (2005)	1
NEDD4L	3	UBE2E1	1	pull down	Todaro DR (2017)	1
OTUB1	0	TRAF6	0	affinity chromatography technology, enzymatic study	Li S (2010), Bremm A (2010)	2
RELA	1	RNF25	1	two hybrid, pull down, pull down, affinity chromatography technology	Asamitsu K (2003), Asamitsu K (2003), Asamitsu K (2003), Asamitsu K (2003)	4
TRIM17	5	TRAF6	0	two hybrid	Woodsmith J (2012)	1
HDAC6	0	USP7	14	affinity chromatography technology	Joshi P (2013)	1
TRIM29	2	RNF8	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yang H (2015), Yang H (2015), Yang H (2015), Yang H (2015)	4
UBE2I	0	MGRN1	4	two hybrid	Markson G (2009)	1
ITCH	1	UBE2E1	1	pull down, pull down	Bai Y (2004), Ahn YH (2009)	2
UBE2I	0	TRIM38	3	two hybrid	Rolland T (2014)	1
PAF1	6	CTR9	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Nordick K (2008), Nordick K (2008), Nordick K (2008), Kim J (2010), Kim J (2010), Mak AB (2010), Mak AB (2010), Takahashi A (2011), Havugimana PC (2012), Wan C (2015), Hein MY (2015)	11
UBE2E1	1	H1F0	3	affinity chromatography technology	Wheaton K (2017)	1
UBE2I	0	DZIP3	6	two hybrid	Markson G (2009)	1
RNF166	0	TRIM39	0	two hybrid	Woodsmith J (2012)	1
USP7	14	TRIM27	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hayes SD (2012), Hein MY (2015), Zaman MM (2013), Zaman MM (2013)	4
UBE2I	0	TRIM27	2	two hybrid, affinity chromatography technology	Markson G (2009), Chu Y (2011)	2
FBXO2	0	STUB1	4	affinity chromatography technology, pull down, enzymatic study	Nelson RF (2006), Nelson RF (2006), Nelson RF (2006)	3
FBXO7	1	RNF20	9	enzymatic study	Teixeira FR (2016)	1
RNF4	1	ATXN1	2	imaging technique, enzymatic study	Guo L (2014), Guo L (2014)	2
TRIM69	0	UBE2E1	1	pull down	Han Y (2012)	1
RNF2	1	H1F0	3	affinity chromatography technology	Cao Q (2014)	1
USP7	14	CHFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oh YM (2007), Oh YM (2009), Oh YM (2009)	3
PRKN	1	MARCH5	0	affinity chromatography technology	Sarraf SA (2013)	1
LRSAM1	2	MKRN3	2	two hybrid	Woodsmith J (2012)	1
ATXN1	2	TRIM38	3	two hybrid	Suter B (2013)	1
CUL3	17	TRIM32	2	affinity chromatography technology	Wimuttisuk W (2014)	1
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
UBE2E1	1	MGRN1	4	two hybrid	Markson G (2009)	1
RNF2	1	H2AFY	1	affinity chromatography technology	Cao Q (2014)	1
UBE2I	0	MARCH5	0	two hybrid	Markson G (2009)	1
TRIB2	2	TRIB1	1	affinity chromatography technology	Huttlin EL (2017)	1
ITCH	1	DTX1	2	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Chastagner P (2008), Chastagner P (2006), Chastagner P (2006), Chastagner P (2006)	4
TRIM27	2	UBE2E1	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
LRSAM1	2	UBE3A	4	biochemical	Kristensen AR (2012)	1
OTUB1	0	UBE2E1	1	affinity chromatography technology, affinity chromatography technology	Scholz CC (2016), Wheaton K (2017)	2
UBE2E1	1	RMND5B	0	two hybrid	van Wijk SJ (2009)	1
BRCA1	7	MAP3K1	4	two hybrid	Woods NT (2012)	1
USP7	14	UBE2E1	1	unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Wheaton K (2017)	6
EPS15	1	USP8	7	affinity chromatography technology, enzymatic study	Mizuno E (2006), Mizuno E (2006)	2