PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	RDH5	3	affinity chromatography technology	Abdelmohsen K (2009)	1
HUWE1	22	UBA1	1	affinity chromatography technology	Thompson JW (2014)	1
UBE2G1	2	APP	1	pull down	Olah J (2011)	1
ELAVL1	0	DIO2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	UBE2G1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	UBA1	1	affinity chromatography technology	Pauli EK (2014)	1
CUL9	5	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pei XH (2011), Pei XH (2011), Skaar JR (2007), Skaar JR (2007), Skaar JR (2007)	5
ITCH	1	UBE2G1	2	pull down, pull down	Gallagher E (2006), Wei W (2012)	2
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
RC3H1	6	UBE2G1	2	pull down	Zhang Q (2015)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
FBXL2	2	APP	1	affinity chromatography technology, enzymatic study	Watanabe T (2012), Watanabe T (2012)	2
CUL9	5	UBE2G1	2	pull down	Gama V (2014)	1
UNK	3	HUWE1	22	affinity chromatography technology	Murn J (2015)	1
CYP3A4	1	UBE2G1	2	affinity chromatography technology	Wang Y (2015)	1
FBXL2	2	UBE2G1	2	pull down	Han S (2015)	1
UBE2G1	2	USP8	7	biochemical	Havugimana PC (2012)	1
RBCK1	0	APP	1	pull down	Olah J (2011)	1
RBX1	2	APP	1	pull down	Olah J (2011)	1
MARCH6	1	UBE2G1	2	pull down	Hassink G (2005)	1
UBE2G1	2	UBE2G1	2	enzymatic study, pull down	David Y (2010), David Y (2010)	2
TRIM25	5	AMFR	2	enzymatic study, pull down	Wang Y (2014), Wang Y (2014)	2
MAP3K1	4	RBCK1	0	enzymatic study	Charlaftis N (2014)	1
PRKN	1	UBE2G1	2	affinity chromatography technology, pull down, pull down, pull down	Imai Y (2001), Kalia SK (2004), Fallon L (2006), Durcan TM (2011)	4
NAXE	2	UBE2G1	2	biochemical	Wan C (2015)	1
TRIM25	5	DIO2	0	affinity chromatography technology	Choudhury NR (2017)	1
RDH5	3	UBE2G1	2	affinity chromatography technology	Huttlin EL (2015)	1
UBE2G1	2	WWP2	7	biochemical	Havugimana PC (2012)	1
UNK	3	UBA1	1	affinity chromatography technology	Murn J (2015)	1
TRIM25	5	HUWE1	22	affinity chromatography technology	Choudhury NR (2017)	1
UBE2G1	2	RBCK1	0	two hybrid	Markson G (2009)	1
RBX1	2	UBE2G1	2	pull down, pull down, pull down	Chen BB (2012), Zou C (2011), Chen BB (2013)	3
ELAVL1	0	ITCH	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PRKN	1	APP	1	affinity chromatography technology, imaging technique	Rosen KM (2010), Lonskaya I (2012)	2
PRKN	1	RBCK1	0	two hybrid	Corominas R (2014)	1
DIO2	0	RBX1	2	affinity chromatography technology	Dentice M (2005)	1
HUWE1	22	UBE2G1	2	pull down	Zhang J (2011)	1
SMURF1	4	RBCK1	0	enzymatic study	Andrews PS (2010)	1
AMFR	2	CYP3A4	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Pabarcus MK (2009), Wang Y (2011), Wang Y (2011), Wang Y (2015), Wang Y (2015)	5
UBE2G1	2	AMFR	2	x-ray crystallography, pull down, pull down, pull down, pull down, pull down	Das R (2009), Wang Y (2011), Ye Y (2003), Ying Z (2009), Wang Y (2011), Wang Y (2015)	6
SMURF1	4	APP	1	pull down	Olah J (2011)	1
MARCH6	1	DIO2	0	affinity chromatography technology, fluorescent resonance energy transfe	Zavacki AM (2009), Egri P (2014)	2
UBA1	1	UBE2G1	2	pull down	Jin J (2007)	1
DIO2	0	UBE2G1	2	fluorescent resonance energy transfe, pull down	Sagar GD (2007), Kim BW (2003)	2
ELAVL1	0	MARCH6	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	RBCK1	0	affinity chromatography technology, imaging technique, pull down, enzymatic study	Inn KS (2011), Inn KS (2011), Inn KS (2011), Inn KS (2011)	4
ELAVL1	0	AMFR	2	affinity chromatography technology	Abdelmohsen K (2009)	1
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
TRIM25	5	UBE2G1	2	affinity chromatography technology	Choudhury NR (2017)	1
ITCH	1	UBA1	1	affinity chromatography technology	OConnor HF (2015)	1
UNK	3	UBE2G1	2	affinity chromatography technology	Murn J (2015)	1
TRIM25	5	RC3H1	6	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	RBX1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SMURF1	4	UBE2G1	2	enzymatic study	Andrews PS (2010)	1
MAP3K1	4	UBE2G1	2	enzymatic study	Charlaftis N (2014)	1
PRKN	1	ELAVL1	0	affinity chromatography technology	Zanon A (2013)	1