PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MARCH8	0	UBE2H	3	pull down	Bartee E (2004)	1
TRIM23	3	TRAIP	0	two hybrid	Woodsmith J (2012)	1
RNF2	1	RNF114	0	affinity chromatography technology	Cao Q (2014)	1
UBE2H	3	RNF186	1	two hybrid	van Wijk SJ (2009)	1
UBE2H	3	TRIM5	4	two hybrid	Markson G (2009)	1
RNF2	1	HDAC2	1	affinity chromatography technology	Cao Q (2014)	1
RMND5B	0	MAEA	3	affinity chromatography technology	Boldt K (2016)	1
TRIM21	0	TRIM5	4	pull down	Li X (2006)	1
TRIM23	3	POLL	3	two hybrid	Rolland T (2014)	1
ELAVL1	0	NEURL1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
MARCH4	0	UBE2H	3	pull down	Bartee E (2004)	1
ELAVL1	0	DTX3L	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2H	3	ARMC8	1	affinity chromatography technology, affinity chromatography technology	Boldt K (2016), Lampert F (2018)	2
ELAVL1	0	PTK2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2H	3	MARCH10	1	two hybrid	Markson G (2009)	1
HNRNPL	3	CD99	0	affinity chromatography technology	Fei T (2017)	1
PRKN	1	UBE2H	3	pull down	Kazlauskaite A (2014)	1
WDR26	6	ARMC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Boldt K (2016), Lampert F (2018), Lampert F (2018), Lampert F (2018)	4
UBE2H	3	IDH1	0	biochemical	Kristensen AR (2012)	1
UBE2H	3	STAM2	0	enzymatic study	Hoeller D (2007)	1
LACTB2	1	TXNL1	2	biochemical	Havugimana PC (2012)	1
UBE2H	3	RNF103	1	two hybrid	van Wijk SJ (2009)	1
LACTB2	1	SSU72	0	biochemical	Havugimana PC (2012)	1
PRKN	1	EPS15	1	pull down, enzymatic study	Fallon L (2006), Fallon L (2006)	2
ARMC8	1	PRDX2	1	affinity chromatography technology	Lampert F (2018)	1
ELAVL1	0	RNF38	4	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAIP	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
CD99	0	UBE2H	3	two hybrid	Kim HJ (2004)	1
THOP1	4	UBE2H	3	biochemical	Havugimana PC (2012)	1
ARMC8	1	HBP1	1	affinity chromatography technology, affinity chromatography technology	Lampert F (2018), Lampert F (2018)	2
RMND5B	0	UBE2H	3	affinity chromatography technology	Boldt K (2016)	1
TRIM72	5	UBE2H	3	pull down, affinity chromatography technology, affinity chromatography technology	Yi JS (2013), Yi JS (2013), Yi JS (2013)	3
UBE2H	3	BRAP	0	two hybrid	Markson G (2009)	1
UBE2H	3	TRIM37	7	two hybrid	Markson G (2009)	1
HNRNPL	3	PTK2	2	affinity chromatography technology	Fei T (2017)	1
UBE2H	3	POLL	3	enzymatic study	Hoeller D (2007)	1
RNF2	1	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
MKRN3	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
UBE2H	3	TRIM27	2	two hybrid	Markson G (2009)	1
RNF4	1	TRAIP	0	two hybrid	Woodsmith J (2012)	1
TRIM21	0	UBE2H	3	pull down	Wada K (2006)	1
RMND5B	0	ARMC8	1	affinity chromatography technology, affinity chromatography technology	Boldt K (2016), Lampert F (2018)	2
RNF38	4	DTX3	4	two hybrid	Woodsmith J (2012)	1
UBE2H	3	RELA	1	enzymatic study	Ryo A (2003)	1
STAM2	0	EPS15	1	affinity chromatography technology	Bache KG (2003)	1
PTK2	2	UBE2H	3	affinity chromatography technology, affinity chromatography technology	Nguyen N (2014), Nguyen N (2014)	2
MARCH1	1	UBE2H	3	pull down	Bartee E (2004)	1
RNF2	1	RELA	1	affinity chromatography technology	Cao Q (2014)	1
TRIM17	5	LRSAM1	2	two hybrid	Woodsmith J (2012)	1
UBE2H	3	WDR26	6	affinity chromatography technology, affinity chromatography technology	Boldt K (2016), Lampert F (2018)	2
UBE2H	3	RNF113B	1	two hybrid	Markson G (2009)	1
PRDX2	1	UBA3	0	biochemical	Havugimana PC (2012)	1
ELAVL1	0	TRIM37	7	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM69	0	UBE2H	3	pull down	Han Y (2012)	1
HBP1	1	WDR26	6	affinity chromatography technology	Lampert F (2018)	1
CDK2	0	UBA1	1	affinity chromatography technology	Neganova I (2011)	1
RNF2	1	BYSL	3	affinity chromatography technology	Cao Q (2014)	1
CDK2	0	TRIM21	0	affinity chromatography technology	Neganova I (2011)	1
BYSL	3	TRIM37	7	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
CDK2	0	UBE2H	3	enzymatic study	Lv Z (2017)	1
UBE2H	3	MAEA	3	enzymatic study	Lampert F (2018)	1
HNRNPL	3	RNF4	1	affinity chromatography technology	Fei T (2017)	1
UBE2H	3	RNF114	0	two hybrid	Markson G (2009)	1
MAEA	3	WDR26	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Boldt K (2016), Lampert F (2018), Lampert F (2018), Lampert F (2018)	4
MAEA	3	ARMC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Boldt K (2016), Lampert F (2018), Lampert F (2018), Lampert F (2018)	4
MARCH2	2	UBE2H	3	pull down	Bartee E (2004)	1
SEC23IP	3	UBE2H	3	biochemical	Havugimana PC (2012)	1
DTX3	4	RNF114	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2H	3	RNF34	1	two hybrid	Markson G (2009)	1
ELAVL1	0	UBE2H	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ANXA6	4	IDH1	0	biochemical	Kristensen AR (2012)	1
TXNDC17	0	UBA3	0	biochemical	Havugimana PC (2012)	1
UBE2H	3	MTAP	3	biochemical	Kristensen AR (2012)	1
TXNDC17	0	TXNL1	2	biochemical	Havugimana PC (2012)	1
ELAVL1	0	IDH1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
RAG1	1	UBE2H	3	pull down	Jones JM (2011)	1
PRDX1	1	PRDX2	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
UBE2H	3	RNF139	4	two hybrid	Markson G (2009)	1
UBE2H	3	RNF185	1	two hybrid	Markson G (2009)	1
TXNL1	2	UBE2H	3	biochemical	Havugimana PC (2012)	1
UBE2H	3	DTX3L	1	two hybrid	Markson G (2009)	1
ELAVL1	0	MARCH2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
THOP1	4	ANXA6	4	biochemical	Kristensen AR (2012)	1
CDK2	0	POLL	3	enzymatic study	Markkanen E (2012)	1
GOT1	2	IDH1	0	biochemical	Kristensen AR (2012)	1
UBE2H	3	MKRN3	2	two hybrid	Markson G (2009)	1
HNRNPL	3	EPS15	1	affinity chromatography technology	Fei T (2017)	1
UBE2H	3	UBAP2L	4	biochemical	Havugimana PC (2012)	1
HDAC6	0	TRIM21	0	affinity chromatography technology	Watson GW (2016)	1
HDAC2	1	UBE2H	3	affinity chromatography technology	Brandl A (2012)	1
UBE2H	3	TRIM17	5	two hybrid	Markson G (2009)	1
UBR2	8	UBE2H	3	pull down	An JY (2012)	1
DZIP3	6	RNF38	4	two hybrid	Woodsmith J (2012)	1
PRDX2	1	UBE2H	3	biochemical	Havugimana PC (2012)	1
RNF2	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
TRIM28	1	TRIM23	3	biochemical	Reymond A (2001)	1
UBE2H	3	RNF4	1	two hybrid	Markson G (2009)	1
UBE2H	3	HDAC6	0	enzymatic study	Hoeller D (2007)	1
TXNDC17	0	UBE2H	3	biochemical	Havugimana PC (2012)	1
UBE2H	3	TRAIP	0	two hybrid	Markson G (2009)	1
PRDX1	1	USP5	2	biochemical	Havugimana PC (2012)	1
UBA3	0	UBE2H	3	biochemical	Havugimana PC (2012)	1
HNRNPL	3	PRKN	1	affinity chromatography technology	Fei T (2017)	1
RNF4	1	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay	Bruderer R (2011), Kuo CY (2014), Kuo CY (2014), Kuo CY (2014), Kuo CY (2014)	5
UBE2H	3	USP5	2	biochemical	Havugimana PC (2012)	1
NHLRC1	3	UBE2H	3	pull down	Gentry MS (2005)	1
PTK2	2	TRIM72	5	affinity chromatography technology, affinity chromatography technology	Nguyen N (2014), Nguyen N (2014)	2
ELAVL1	0	HDAC2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
EPS15	1	PRDX1	1	affinity chromatography technology	Brehme M (2009)	1
ELAVL1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Scott GK (2008), Scott GK (2008)	2
MTAP	3	ANXA6	4	biochemical	Kristensen AR (2012)	1
DZIP3	6	UBR3	13	two hybrid	Woodsmith J (2012)	1
TRIM23	3	UBOX5	4	two hybrid	Woodsmith J (2012)	1
RNF128	1	UBE2H	3	pull down	Anandasabapathy N (2003)	1
HBP1	1	MAEA	3	affinity chromatography technology	Lampert F (2018)	1
HNRNPL	3	MARCH1	1	affinity chromatography technology	Fei T (2017)	1
SEC23IP	3	SSU72	0	biochemical	Havugimana PC (2012)	1
SSU72	0	UBE2H	3	biochemical	Havugimana PC (2012)	1
RNF34	1	TRIM23	3	two hybrid	Woodsmith J (2012)	1
TRIM5	4	MKRN3	2	two hybrid	Woodsmith J (2012)	1
PRKN	1	UBASH3B	4	pull down	Ikeda F (2007)	1
HNRNPL	3	ANXA6	4	affinity chromatography technology	Fei T (2017)	1
ELAVL1	0	TRIM2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF114	0	RNF38	4	two hybrid	Woodsmith J (2012)	1
HNRNPL	3	THOP1	4	affinity chromatography technology	Fei T (2017)	1
PRDX2	1	SEC23IP	3	biochemical	Havugimana PC (2012)	1
UBE2H	3	TRIM23	3	two hybrid	Markson G (2009)	1
TRIM28	1	UBE2H	3	pull down	Doyle JM (2010)	1
GOT1	2	ANXA6	4	biochemical	Kristensen AR (2012)	1
UBE2H	3	RNF133	1	two hybrid	Markson G (2009)	1
CDK2	0	PRDX2	1	affinity chromatography technology	Neganova I (2011)	1
LACTB2	1	UBE2H	3	biochemical	Havugimana PC (2012)	1
ELAVL1	0	UBASH3B	4	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
RNF166	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2H	3	TRIM2	1	two hybrid	Markson G (2009)	1
GOT1	2	UBE2H	3	biochemical	Kristensen AR (2012)	1
HNRNPL	3	UBE2H	3	affinity chromatography technology	Fei T (2017)	1
TRIM21	0	TRIM27	2	two hybrid	Woodsmith J (2012)	1
RELA	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kiernan R (2003), Yu Z (2002), Yu Z (2002), Ito K (2001), Ito K (2000), Sun JM (2007), Adenuga D (2010), Wang H (2010), Chen TC (2014)	9
UBE2H	3	RNF10	0	two hybrid	Markson G (2009)	1
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
TXNDC17	0	USP5	2	biochemical	Havugimana PC (2012)	1
CDK2	0	TRIM28	1	affinity chromatography technology	Neganova I (2011)	1
RNF2	1	HNRNPL	3	affinity chromatography technology	Cao Q (2014)	1
UBE2H	3	RNF144A	1	two hybrid	Markson G (2009)	1
UBE2H	3	DZIP3	6	two hybrid	Markson G (2009)	1
TRIM21	0	DZIP3	6	two hybrid	Woodsmith J (2012)	1
CDK2	0	PRDX1	1	affinity chromatography technology	Neganova I (2011)	1
RNF2	1	TRIM56	0	affinity chromatography technology	Cao Q (2014)	1
THOP1	4	IDH1	0	biochemical	Kristensen AR (2012)	1
BYSL	3	TRIM27	2	two hybrid	Rolland T (2014)	1
USP5	2	UBA1	1	affinity chromatography technology	Song AX (2014)	1
UBE2H	3	RNF6	4	two hybrid	Markson G (2009)	1
ELAVL1	0	MTAP	3	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAIP	0	UBOX5	4	two hybrid	Woodsmith J (2012)	1
RNF2	1	TRIM28	1	affinity chromatography technology	Cao Q (2014)	1
HDAC6	0	RELA	1	affinity chromatography technology	Yang CJ (2015)	1
ELAVL1	0	UBAP2L	4	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2H	3	RNF2	1	two hybrid	Markson G (2009)	1
UBE2H	3	CBLC	1	two hybrid	Markson G (2009)	1
SSU72	0	THOP1	4	biochemical	Havugimana PC (2012)	1
UBE2H	3	HBP1	1	enzymatic study	Lampert F (2018)	1
UBA1	1	UBE2H	3	pull down, enzymatic study	Jin J (2007), Huguenin-Dezot N (2016)	2
UBE2H	3	TRIM56	0	two hybrid	van Wijk SJ (2009)	1
UBE2H	3	ANXA6	4	biochemical	Kristensen AR (2012)	1
PRKN	1	PRDX1	1	affinity chromatography technology	Zanon A (2013)	1
UBA3	0	UFC1	0	biochemical	Havugimana PC (2012)	1
UBE2H	3	TRIM36	0	two hybrid	Markson G (2009)	1
BYSL	3	UBE2H	3	two hybrid	Rolland T (2014)	1
UBE2H	3	DTX3	4	two hybrid	Markson G (2009)	1
UBE2H	3	EPS15	1	enzymatic study	Hoeller D (2007)	1
HNRNPL	3	UBAP2L	4	affinity chromatography technology	Fei T (2017)	1
UBE2H	3	UBOX5	4	two hybrid	Markson G (2009)	1
SSU72	0	HNRNPL	3	affinity chromatography technology	St-Denis N (2016)	1
UBE2H	3	LRSAM1	2	two hybrid	Markson G (2009)	1
UBE2H	3	RNF146	4	two hybrid	Markson G (2009)	1
RNF166	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBE2H	3	POLM	5	enzymatic study	Hoeller D (2007)	1
HDAC6	0	TRIM27	2	affinity chromatography technology	Joshi P (2013)	1
CDK2	0	IDH1	0	affinity chromatography technology	Neganova I (2011)	1
GOT1	2	MTAP	3	biochemical	Kristensen AR (2012)	1
HNRNPL	3	UBR2	8	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	RNF144A	1	affinity chromatography technology	Fei T (2017)	1
TXNL1	2	USP5	2	biochemical	Havugimana PC (2012)	1
RNF216	2	UBE2H	3	affinity chromatography technology	Chuang TH (2004)	1
LRSAM1	2	MKRN3	2	two hybrid	Woodsmith J (2012)	1
PRDX1	1	UBE2H	3	biochemical	Havugimana PC (2012)	1
UBE2H	3	UBE2H	3	enzymatic study	David Y (2010)	1
JADE1	6	UBE2H	3	pull down	Chitalia VC (2008)	1
UBE2H	3	NEURL1	0	two hybrid	van Wijk SJ (2009)	1
UBR3	13	UBE2H	3	pull down	Meisenberg C (2012)	1
UBE2H	3	RNF166	0	two hybrid	Markson G (2009)	1
UBE2H	3	RNF38	4	two hybrid	Markson G (2009)	1
HNRNPL	3	MAEA	3	affinity chromatography technology	Fei T (2017)	1
RMND5B	0	WDR26	6	affinity chromatography technology, affinity chromatography technology	Boldt K (2016), Lampert F (2018)	2
ELAVL1	0	EPS15	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2H	3	UFC1	0	biochemical	Havugimana PC (2012)	1
PRKN	1	ELAVL1	0	affinity chromatography technology	Zanon A (2013)	1
USP5	2	TRIM5	4	two hybrid	Hayes SD (2012)	1
UBE2H	3	UBASH3B	4	enzymatic study	Hoeller D (2007)	1