Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
UMOD 7369 RETINOL CHEMBL986 NCI 6224621

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
UMOD rs12917707 GT + TT cyclosporine efficacy yes In death-censored adjusted multivariate analysis, the presence of the DONOR T allele was associated with a significantly lower hazard ratio for graft loss. No significant results were seen when looking at RECIPIENT genotype. Additionally, no significant results were found for blood pressure, serum creatinine or acute graft rejections 1 year after transplantation. No association with graft survival was found in Kaplan-Meier analysis (0.65). Genotypes GT + TT is associated with increased response to cyclosporine in people with Kidney Transplantation as compared to genotype GG. 28418009 1449154836