PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VPS11	3	VPS33A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001), Hein MY (2015), van der Kant R (2015), van der Kant R (2015)	5
VPS33A	0	TGFBRAP1	2	affinity chromatography technology	van der Kant R (2015)	1
XPO1	8	PIK3R4	3	affinity chromatography technology	Kirli K (2015)	1
UVRAG	2	PIK3R4	3	affinity chromatography technology	Behrends C (2010)	1
VPS18	4	TGFBRAP1	2	affinity chromatography technology	Hein MY (2015)	1
UVRAG	2	CUL4A	2	affinity chromatography technology, affinity chromatography technology	Yang Y (2016), Yang Y (2016)	2
UVRAG	2	RUBCN	3	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Matsunaga K (2009)	2
RUBCN	3	PIK3R4	3	affinity chromatography technology	Matsunaga K (2009)	1
DDB2	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, imaging technique	Kapetanaki MG (2006), Takedachi A (2010), Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Matsumoto S (2015), Hein MY (2015), Groisman R (2006), Groisman R (2006), Chitale S (2017)	10
UVRAG	2	VPS11	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liang C (2008), Liang C (2008), Liang C (2008)	3
UVRAG	2	VPS33A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Liang C (2008), Liang C (2008), Jiang P (2014)	4
RALB	0	UVRAG	2	affinity chromatography technology	Bodemann BO (2011)	1
CUL4A	2	DDB2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Kapetanaki MG (2006), Matsuda N (2005), Higa LA (2006), Nag A (2001), Takedachi A (2010), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), Groisman R (2003), Groisman R (2003), Hrecka K (2007), Shiyanov P (1999), Shiyanov P (1999), Bennett EJ (2010), Kulaksiz G (2005), Kulaksiz G (2005), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Groisman R (2003), Huttlin EL (2015), Hein MY (2015), Groisman R (2006), Yang Y (2016), Huttlin EL (2017), Fantini D (2017)	31
UVRAG	2	DDB1	6	affinity chromatography technology, affinity chromatography technology	Yang Y (2016), Yang Y (2016)	2
UVRAG	2	VPS33B	2	affinity chromatography technology, affinity chromatography technology	Liang C (2008), Liang C (2008)	2
RUBCNL	1	PIK3R4	3	affinity chromatography technology	Huttlin EL (2017)	1
UVRAG	2	VPS18	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Liang C (2008), Liang C (2008)	3
VPS33A	0	VPS16	6	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wartosch L (2015), Hein MY (2015), Graham SC (2013), Graham SC (2013), Graham SC (2013), van der Kant R (2015), van der Kant R (2015)	8
BECN1	2	RUBCN	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Ma B (2014), Hein MY (2015), Chauhan S (2015), Lei Y (2016)	8
PIK3C3	1	USP18	1	affinity chromatography technology	Xu D (2015)	1
RUBCNL	1	PIK3C3	1	affinity chromatography technology	Huttlin EL (2017)	1
BECN1	2	PIK3C3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Platta HW (2012), Platta HW (2012), Platta HW (2012), Wang J (2008), Xia P (2013), Luciani A (2010), Luciani A (2010), Matsunaga K (2009), Ma B (2014), Xia P (2014), Itakura E (2008), Itakura E (2008), Sun Q (2008), Sun Q (2008), Sun Q (2008), Pattingre S (2005), Luo S (2010), Ramachandran N (2013), Fogel AI (2013), Xu D (2015), Hein MY (2015), Ma B (2015), Zeng X (2006), Verma N (2017), Wei Y (2015), Stjepanovic G (2017), Liu X (2017), Li X (2017)	30
UVRAG	2	VPS39	3	affinity chromatography technology, affinity chromatography technology	Liang C (2008), Liang C (2008)	2
DDB2	1	DDB1	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bergametti F (2002), Martinez E (2001), Guerrero-Santoro J (2008), Angers S (2006), Wang H (2006), Kapetanaki MG (2006), Kapetanaki MG (2006), Higa LA (2006), Takedachi A (2010), Fischer ES (2011), Scrima A (2008), Groisman R (2003), Groisman R (2003), Schroefelbauer B (2007), Kulaksiz G (2005), Inoki T (2004), Bontron S (2002), Rapic-Otrin V (2003), Olma MH (2009), Liu W (2000), Jin J (2006), Huttlin EL (2015), Zhao R (2014), Xie X (2015), Groisman R (2006), Yang Y (2016), Huttlin EL (2017), Chitale S (2017), Fantini D (2017), Fantini D (2017), Ohtake F (2007)	31
BECN1	2	DDB1	6	affinity chromatography technology	Antonioli M (2014)	1
DDB1	6	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Wang H (2006), Kapetanaki MG (2006), Hu J (2004), Ahn J (2010), Fischer ES (2011), Groisman R (2006)	6
UVRAG	2	RBX1	2	affinity chromatography technology	Yang Y (2016)	1
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
VPS11	3	TGFBRAP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), van der Kant R (2015), Huttlin EL (2017)	4
UVRAG	2	TGFBRAP1	2	affinity chromatography technology	Behrends C (2010)	1
UVRAG	2	PTPRA	3	affinity chromatography technology	Behrends C (2010)	1
VPS33A	0	VPS18	4	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Havugimana PC (2012), Wan C (2015), Wartosch L (2015), Wartosch L (2015), Wartosch L (2015), Hein MY (2015), van der Kant R (2015), van der Kant R (2015), Hunter MR (2017)	10
RUBCNL	1	UVRAG	2	affinity chromatography technology	Huttlin EL (2017)	1
PIK3C3	1	PIK3R4	3	affinity chromatography technology, biochemical, pull down	Behrends C (2010), Wan C (2015), Stjepanovic G (2017)	3
MYO1C	5	UVRAG	2	affinity chromatography technology	Hein MY (2015)	1
BECN1	2	RUBCNL	1	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2017)	2
UVRAG	2	VPS16	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Liang C (2008), Liang C (2008), Liang C (2008), Liang C (2008)	4
YWHAE	0	RUBCN	3	affinity chromatography technology	Choudhary C (2009)	1
UVRAG	2	DDB2	1	affinity chromatography technology	Yang Y (2016)	1
PIK3C3	1	RUBCN	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Matsunaga K (2009), Ma B (2014)	3
UVRAG	2	USP18	1	affinity chromatography technology	Xu D (2015)	1
YWHAE	0	UVRAG	2	affinity chromatography technology	Choudhary C (2009)	1
VPS16	6	TGFBRAP1	2	affinity chromatography technology	Hein MY (2015)	1
VPS11	3	VPS39	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), van der Kant R (2015), Huttlin EL (2017)	4
BECN1	2	USP18	1	affinity chromatography technology	Xu D (2015)	1
VPS11	3	VPS18	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001), Huttlin EL (2015), Wartosch L (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017), Hunter MR (2017)	8
YWHAE	0	XPO1	8	biochemical	Kristensen AR (2012)	1
YWHAE	0	PIK3R4	3	affinity chromatography technology	Choudhary C (2009)	1
RBX1	2	CUL4A	2	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, enzymatic study, pull down, biochemical	Dias DC (2002), Ohta T (1999), Guerrero-Santoro J (2008), Hu J (2004), Furukawa M (2002), Maddika S (2009), Tron AE (2012), Tron AE (2012), He YJ (2006), Gastaldello S (2012), Olma MH (2009), Kristensen AR (2012), Huang DT (2009), Pick E (2007), Yang Y (2016), Scherer PC (2016), Nguyen TV (2016)	17
XPO1	8	UVRAG	2	affinity chromatography technology	Kirli K (2015)	1
VPS16	6	VPS18	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001), Havugimana PC (2012), Wartosch L (2015), Wartosch L (2015), Wartosch L (2015), Hein MY (2015), Hein MY (2015), Graham SC (2013), van der Kant R (2015), van der Kant R (2015)	11
XPO1	8	BECN1	2	affinity chromatography technology	Kirli K (2015)	1
BECN1	2	UVRAG	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Noble CG (2008), Itakura E (2008), Itakura E (2008), Sun Q (2008), Sun Q (2008), Sun Q (2008), Sun Q (2008), Fogel AI (2013), Hein MY (2015), Yang Y (2016)	16
PIK3C3	1	UVRAG	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Ma B (2014), Itakura E (2008), Itakura E (2008)	5
BECN1	2	PIK3R4	3	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Luciani A (2010), Luciani A (2010), Matsunaga K (2009), Sun Q (2008), Fogel AI (2013), Hein MY (2015)	7
VPS11	3	VPS16	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001), Hein MY (2015), Hein MY (2015), van der Kant R (2015), van der Kant R (2015)	6