PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VHL	0	HNRNPL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lai Y (2011), Yao P (2013), Yao P (2013)	3
BRCA1	7	VEGFA	3	genetic interference	Shen JP (2017)	1
VEGFA	3	VPS35	2	two hybrid	Wang J (2011)	1
U2AF1	0	VEGFA	3	two hybrid	Wang J (2011)	1
VEGFA	3	LYVE1	0	pull down	Boensch C (1995)	1
VEGFA	3	FLT1	4	pull down, affinity chromatography technology	Allain B (2012), Huttlin EL (2017)	2
ELAVL1	0	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Abdelmohsen K (2009), Datta K (2005), Datta K (2005), Yuen JS (2007)	4
HSP90AA1	7	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Johnson N (2013), Johnson N (2013), Ertych N (2016)	3
HSP90AA1	7	HIF1A	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hogenesch JB (1997), Qian DZ (2006), Kong X (2006), Kubo T (2004), Zhou J (2004), Fu B (2007), Choi YK (2010), Choi YK (2010), Lee JM (2011), Liu YV (2007), Liu YV (2007), Katschinski DM (2004), Katschinski DM (2004), Katschinski DM (2004), Trisciuoglio D (2010), Trisciuoglio D (2010), Ueda K (2008), Sun H (2013), Kawanami D (2009), Prince TL (2015), Prince TL (2015), Isaacs JS (2004), Lee SH (2015)	23
BRCA1	7	HNRNPL	3	affinity chromatography technology	Ertych N (2016)	1
HSP90AA1	7	STAT3	0	affinity chromatography technology	Sato N (2003)	1
HIF1A	1	VEGFA	3	imaging technique	Pawlus MR (2013)	1
VEGFA	3	VHL	0	genetic interference	Shen JP (2017)	1
ELAVL1	0	VEGFA	3	unspecified method, affinity chromatography technology	Datta K (2005), Xin H (2011)	2
HIF1A	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kong X (2006), Qian DZ (2006), Kong X (2006), Zhou J (2004), Zhou J (2004), van de Sluis B (2009), Luo W (2010), Luo W (2010), Luo W (2010), Bento CF (2010), Katschinski DM (2004), Sun H (2013)	12
FLT1	4	KDR	4	enzymatic study, affinity chromatography technology	Autiero M (2003), Raikwar NS (2014)	2
HSPA4	3	CRYAB	0	affinity chromatography technology	Chavez Zobel AT (2003)	1
ELAVL1	0	CTGF	1	affinity chromatography technology	Abdelmohsen K (2009)	1
HNRNPL	3	VEGFA	3	affinity chromatography technology	Yao P (2013)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
ILF3	5	VTN	1	biochemical	Havugimana PC (2012)	1
VEGFA	3	CRYAB	0	affinity chromatography technology, unspecified method	Ruan Q (2011), Ghosh JG (2007)	2
IGFBP7	1	VEGFA	3	pull down	Usui T (2002)	1
MDM2	2	CLU	1	pull down	Miyamoto-Sato E (2010)	1
HSP90AA1	7	CHEK1	2	affinity chromatography technology, pull down, affinity chromatography technology	Ha K (2011), Arlander SJ (2006), Taipale M (2012)	3
CHEK1	2	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference	Yarden RI (2002), Yarden RI (2002), Inoue Y (2007), Shen JP (2017)	4
HNRNPD	3	HNRNPL	3	biochemical	Havugimana PC (2012)	1
ILF3	5	HSP90AA1	7	affinity chromatography technology	Chu L (2012)	1
PGF	0	VEGFA	3	biochemical, imaging technique	Eriksson A (2002), Chen TC (2014)	2
VEGFA	3	PTPRB	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Koutsioumpa M (2015), Koutsioumpa M (2015), Koutsioumpa M (2015)	3
VEGFB	2	VEGFA	3	affinity chromatography technology, imaging technique, affinity chromatography technology	Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017)	3
FLT1	4	VEGFB	2	affinity chromatography technology, pull down, pull down	Olofsson B (1998), Olofsson B (1998), Makinen T (1999)	3
USF2	3	VEGFA	3	imaging technique	Pawlus MR (2013)	1
HNRNPD	3	VEGFA	3	unspecified method, affinity chromatography technology, affinity chromatography technology, unspecified method	Xin H (2011), Xin H (2011), Kishor A (2013), Kishor A (2013)	4
HIF1A	1	STAT3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jung JE (2008), Jung JE (2008), Gray MJ (2005), Gray MJ (2005), Pawlus MR (2013), Pawlus MR (2013)	6
HNRNPD	3	BRCA1	7	affinity chromatography technology, two hybrid, affinity chromatography technology	Shimizu Y (2012), Lehner B (2004), Ertych N (2016)	3
NRP1	2	PGF	0	pull down	Mamluk R (2002)	1
VHL	0	HSP90AA1	7	affinity chromatography technology, genetic interference	Yang C (2013), Shen JP (2017)	2
HNRNPL	3	PTPRB	4	affinity chromatography technology	Fei T (2017)	1
PRRG4	1	VEGFA	3	two hybrid	Wang J (2011)	1
HGS	5	VPS35	2	affinity chromatography technology	Popoff V (2009)	1
BRCA1	7	ILF3	5	affinity chromatography technology	Ertych N (2016)	1
VEGFA	3	KDR	4	enzymatic study, pull down, pull down, imaging technique, pull down	Luque A (2003), Di Benedetto M (2008), Tirand L (2006), Koutsioumpa M (2015), Patel NS (2010)	5
NRP1	2	VEGFA	3	pull down, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down	Mamluk R (2002), Soker S (1998), Soker S (1998), Parker MW (2012), Parker MW (2012), Di Benedetto M (2008), Tirand L (2006), Allain B (2012), Novoa A (2010)	9
VHL	0	ACTBL2	0	affinity chromatography technology	Huttlin EL (2017)	1
NRP1	2	VEGFB	2	pull down	Makinen T (1999)	1
VHL	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, far western blotting, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down, protein complementation assay, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Corn PG (2003), Li Z (2003), Mahon PC (2001), Tanimoto K (2000), Min JH (2002), Yu F (2001), Yu F (2001), Jung JE (2008), Jung JE (2008), Andre H (2008), Park YK (2008), Kim BY (2008), Park SS (2008), Baek JH (2007), Baek JH (2007), Baek JH (2007), Kondo S (2006), Ietta F (2006), Kwon SJ (2005), Bae MK (2005), Baek JH (2005), Hon WC (2002), Hon WC (2002), Lewis MD (2004), Kasuno K (2004), Metzen E (2003), Metzen E (2003), Zhou J (2003), Yuan Y (2003), Maynard MA (2003), Jeong JW (2002), Yoo YG (2008), Hansen WJ (2002), Masson N (2001), Masson N (2001), Clifford SC (2001), Jaakkola P (2001), Jaakkola P (2001), Kamura T (2000), Kamura T (2000), Kamura T (2000), Ohh M (2000), Ohh M (2000), Cockman ME (2000), Cockman ME (2000), Sufan RI (2006), Chang CC (2011), Sufan RI (2009), Stickle NH (2004), Luo W (2010), Lee HY (2011), Roe JS (2011), Ivan M (2001), Ivan M (2001), Huang LE (2002), Callapina M (2005), Callapina M (2005), Maranchie JK (2002), DAngelo G (2003), DAngelo G (2003), Miller F (2005), Grosfeld A (2007), Grosfeld A (2007), Rajakumar A (2008), Bonicalzi ME (2001), Bemis L (2004), Berra E (2001), Yu F (2001), Bex C (2007), Zhou J (2012), Wiesener MS (2002), Maxwell PH (1999), Maxwell PH (1999), Lee SH (2012), Lee SH (2012), Ivan M (2002), Aprelikova O (2009), Choi CY (2009), Choi CY (2009), Heir P (2013), Russell RC (2008), Russell RC (2008), Park JH (2011), Park JH (2011), Liu Q (2013), Yeh IJ (2013), Choi YK (2010), Yang F (2014), Yang F (2014), Yang F (2014), Parsanejad M (2014), Yang C (2013), Yang C (2013), Chen K (2013), Park MH (2014), Gerez J (2015), Hein MY (2015), Park MH (2015), Fu R (2016), Alahari S (2015), Zhang CS (2015), Song D (2013), Chen K (2016), Hicks KC (2016), Groulx I (2002), Groulx I (2002), Groulx I (2002), Huttlin EL (2017), Guo J (2016), Sun W (2017), Sun W (2017), Guo J (2016), Li YM (2005), Yoo YG (2004), Kimura M (2008), Ferrer CM (2014)	116
HNRNPD	3	CHEK1	2	biochemical	Wan C (2015)	1
VEGFA	3	PTPRZ1	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Koutsioumpa M (2015), Koutsioumpa M (2015), Koutsioumpa M (2015)	3
MDM2	2	HSPA4	3	affinity chromatography technology	Lu TL (2010)	1
ELAVL1	0	HIF1A	1	affinity chromatography technology, unspecified method	Galban S (2008), Galban S (2008)	2
VEGFA	3	HSP90AA1	7	affinity chromatography technology	Park JH (2008)	1
BRCA1	7	VPS35	2	affinity chromatography technology	Ertych N (2016)	1
VTN	1	VEGFA	3	pull down	Schoppet M (2002)	1
ILF3	5	VEGFA	3	affinity chromatography technology	Yao P (2013)	1
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
MDM2	2	HSP90AA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, biochemical, unspecified method, affinity chromatography technology	Lu TL (2010), Burch L (2004), Burch L (2004), Burch L (2004), Burch L (2004), Burch LR (2004), Okoro DR (2013)	7
CHEK1	2	VEGFA	3	genetic interference	Shen JP (2017)	1
MDM2	2	HIF1A	1	pull down, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Chen D (2003), Chen D (2003), Ravi R (2000), Lee YM (2009), Lee YM (2009), Lee YM (2009), Maroni P (2014), Amelio I (2015), Yoo YG (2004), LaRusch GA (2007), LaRusch GA (2007), Nieminen AL (2005)	12
CHEK1	2	VHL	0	genetic interference	Shen JP (2017)	1
SPARC	1	VEGFA	3	far western blotting	Kupprion C (1998)	1
HNRNPL	3	NRP1	2	affinity chromatography technology	Fei T (2017)	1
STAT3	0	VEGFA	3	imaging technique	Pawlus MR (2013)	1
ADAMTS1	1	VEGFA	3	biochemical, affinity chromatography technology, pull down	Luque A (2003), Luque A (2003), Luque A (2003)	3
ELAVL1	0	VPS35	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HNRNPD	3	NRP1	2	affinity chromatography technology	Hein MY (2015)	1
VHL	0	HNRNPD	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down	Lai Y (2011), Xin H (2011), Xin H (2011), Xin H (2011), Xin H (2011), Xin H (2011)	6
MDM2	2	VEGFA	3	affinity chromatography technology, unspecified method	Xiong J (2017), Xiong J (2017)	2
USF2	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Cable PL (2003), Cable PL (2003)	2
BRCA1	7	HIF1A	1	affinity chromatography technology, affinity chromatography technology	Kang HJ (2006), Kang HJ (2006)	2
HNRNPD	3	HSPA4	3	affinity chromatography technology, affinity chromatography technology, pull down	Sinsimer KS (2008), Laroia G (1999), Lu JY (2006)	3
VHL	0	ILF3	5	affinity chromatography technology	Yao P (2013)	1
CLU	1	VEGFA	3	affinity chromatography technology, affinity chromatography technology	Li Y (2016), Li Y (2016)	2
UBIAD1	0	VEGFA	3	two hybrid	Nickerson ML (2013)	1
VEGFA	3	VEGFA	3	biochemical, biochemical, x-ray crystallography	Eriksson A (2002), Keyt BA (1996), Muller YA (1997)	3
NRP1	2	KDR	4	affinity chromatography technology	Ohsaka A (2009)	1
MDM2	2	HNRNPD	3	affinity chromatography technology	Jacob AG (2014)	1
BRCA1	7	HSPA4	3	affinity chromatography technology	Ertych N (2016)	1
FLT1	4	PGF	0	pull down	Davis-Smyth T (1998)	1
MDM2	2	ILF3	5	affinity chromatography technology	Okoro DR (2013)	1
HNRNPL	3	ILF3	5	affinity chromatography technology, pull down, affinity chromatography technology	Yao P (2013), Yao P (2013), Yao P (2013)	3
VEGFA	3	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Park JH (2008), Kishor A (2013)	2
VHL	0	HSPA4	3	affinity chromatography technology	Yang C (2013)	1
VEGFA	3	GPC1	4	pull down	Gengrinovitch S (1999)	1
ELAVL1	0	STAT3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
VHL	0	CLU	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Xue J (2012), Xue J (2012), Xue J (2012), Xue J (2012)	4
CTGF	1	VEGFA	3	affinity chromatography technology, pull down	Inoki I (2002), Inoki I (2002)	2
HNRNPL	3	HIF1A	1	affinity chromatography technology	Fei T (2017)	1
VEGFA	3	ACTBL2	0	affinity chromatography technology	Huttlin EL (2017)	1
NRP2	2	VEGFA	3	pull down	Geretti E (2007)	1
HGS	5	VEGFA	3	affinity chromatography technology	Hasseine LK (2007)	1