PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
SMURF1	4	ANKRD13A	1	enzymatic study	Andrews PS (2010)	1
LDLRAD4	1	MAGI1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
SMURF1	4	EPN1	4	enzymatic study	Andrews PS (2010)	1
LDLRAD4	1	NCAPH2	4	affinity chromatography technology	Huttlin EL (2015)	1
LDLRAD4	1	NCAPD3	6	affinity chromatography technology	Huttlin EL (2015)	1
ACVR2B	0	SMAD2	5	affinity chromatography technology	Miura S (2000)	1
LDLRAD4	1	CSNK1E	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	FLCN	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
NEDD4	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Huttlin EL (2017)	2
YAP1	0	SMAD2	5	affinity chromatography technology	Pefani DE (2016)	1
LDLRAD4	1	UBR3	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD2	5	CSNK1D	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Brown KA (2008), Ding L (2009), Ding L (2009)	3
LDLRAD4	1	ACVR2A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWOX	3	SMAD3	1	pull down, affinity chromatography technology	Ferguson BW (2013), Ferguson BW (2013)	2
SMAD2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005)	2
SMURF1	4	ANKRD13D	4	enzymatic study	Andrews PS (2010)	1
SMAD3	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Seo SR (2004), Rolland T (2014)	3
RNF31	3	SMAD3	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
ITCH	1	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology	Shembade N (2008), Shembade N (2008)	2
LDLRAD4	1	HECW1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD2	5	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
ITCH	1	WWP1	3	affinity chromatography technology	OConnor HF (2015)	1
SMAD2	5	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Runyan CE (2009), Runyan CE (2009), Chong PA (2010), Brown KA (2008), Colland F (2004), Colland F (2004), Zhang Y (2017), Zhou F (2017), Zhou F (2017)	16
LDLRAD4	1	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	ANKRD13D	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD4L	3	CUEDC1	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
LDLRAD4	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD3	1	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Tang LY (2011), Brown KA (2008), Zhang L (2013), Li Y (2017), Zhang Y (2017)	12
LDLRAD4	1	ACVR2B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMURF2	3	CUEDC1	4	two hybrid	Colland F (2004)	1
LDLRAD4	1	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	SUFU	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD2	5	WASHC4	0	two hybrid	Colland F (2004)	1
LDLRAD4	1	ARFGEF2	9	affinity chromatography technology	Huttlin EL (2015)	1
LDLRAD4	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD2	5	SMURF1	4	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Ito I (2010), Colland F (2004)	3
LDLRAD4	1	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FGFR1	2	NEDD4	2	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Persaud A (2011), Persaud A (2011), Persaud A (2009), Persaud A (2014)	4
LDLRAD4	1	VPS18	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	UIMC1	4	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4	2	RBCK1	0	pull down	Persaud A (2009)	1
LDLRAD4	1	PLCG1	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWP2	7	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Brown KA (2008)	3
LDLRAD4	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMURF1	4	CSNK1D	3	enzymatic study	Andrews PS (2010)	1
LDLRAD4	1	CALCOCO2	0	affinity chromatography technology	Huttlin EL (2015)	1
LDLRAD4	1	SMAD2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YAP1	0	ITCH	1	affinity chromatography technology	Levy D (2007)	1
LDLRAD4	1	UBR1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMURF1	4	RBCK1	0	enzymatic study	Andrews PS (2010)	1
SMAD3	1	SMURF1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Colland F (2004), Li Y (2017), Li Y (2017)	4
FGFR1	2	PLCG1	6	two hybrid, imaging technique, two hybrid, pull down, enzymatic study, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Xu H (1998), Chen TC (2014), Hu Y (2004), Shi E (1993), Shi E (1993), Bae JH (2009), Bae JH (2009), Bae JH (2009), Browaeys-Poly E (2010), Browaeys-Poly E (2010), Vecchione A (2007)	11
NEDD4	2	CUEDC1	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
HECW2	13	HECW1	3	affinity chromatography technology	Lu L (2013)	1
WWP2	7	SMAD3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid	Soond SM (2011), Soond SM (2011), Soond SM (2011), Brown KA (2008), Soond SM (2013), Yu H (2011)	6
LDLRAD4	1	FGFR1	2	affinity chromatography technology	Huttlin EL (2015)	1
LDLRAD4	1	DPY19L1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	WWC2	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	WASHC4	0	affinity chromatography technology	Huttlin EL (2017)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
SMAD3	1	YAP1	0	affinity chromatography technology	Alarcon C (2009)	1
NEDD4	2	ANKRD13D	4	enzymatic study	Persaud A (2009)	1
LDLRAD4	1	CMTR1	3	affinity chromatography technology	Huttlin EL (2015)	1
LDLRAD4	1	HECW2	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	WWP2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	WWOX	3	affinity chromatography technology	Huttlin EL (2015)	1
LDLRAD4	1	WWP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCAPH2	4	NCAPD3	6	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Onn I (2007), Ono T (2003), Ono T (2003), Wan C (2015), Hein MY (2015), Li W (2015), Huttlin EL (2017)	7
LDLRAD4	1	USP22	1	affinity chromatography technology	Huttlin EL (2017)	1
LDLRAD4	1	USP33	1	affinity chromatography technology	Huttlin EL (2015)	1
LDLRAD4	1	DHX38	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
LDLRAD4	1	ANKRD13A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	CSNK1D	3	affinity chromatography technology	Huttlin EL (2015)	1
ITCH	1	SMAD2	5	enzymatic study, affinity chromatography technology	Bai Y (2004), Bai Y (2004)	2
LDLRAD4	1	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD4	2	CSNK1D	3	affinity chromatography technology	Liu J (2014)	1
SMURF1	4	CUEDC1	4	enzymatic study	Andrews PS (2010)	1
LDLRAD4	1	EPN1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	MAGI3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CSNK1E	0	CSNK1D	3	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
LDLRAD4	1	YAP1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CALCOCO2	0	TAX1BP1	3	affinity chromatography technology, two hybrid	Morriswood B (2007), Morriswood B (2007)	2
LDLRAD4	1	STXBP4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITCH	1	SMAD3	1	pull down	Feng L (2004)	1
SMAD2	5	NEDD4L	3	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Gao S (2009), Colland F (2004), Gao S (2009), Yan X (2016)	4
LDLRAD4	1	RTFDC1	0	affinity chromatography technology	Huttlin EL (2015)	1
WWOX	3	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Abu-Odeh M (2014), Abu-Odeh M (2014)	3
SMAD3	1	CSNK1D	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Brown KA (2008), Ding L (2009), Ding L (2009)	3
LDLRAD4	1	TOMM40	1	affinity chromatography technology	Huttlin EL (2015)	1
LDLRAD4	1	KIDINS220	4	affinity chromatography technology	Huttlin EL (2015)	1
NEDD4L	3	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology	Gao S (2009), Gao S (2009), Aragon E (2012), Herhaus L (2013), Gao S (2009), Gao S (2009), Yan X (2016)	7
SMAD3	1	NEDD4	2	affinity chromatography technology, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down	Kuratomi G (2005), Persaud A (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011)	6
LDLRAD4	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2