PPI network (data source: BioGrid)

Symbol A GeneA coding DNM count Symbol B GeneB coding DNM count Interaction detection method Publication Evidence
WWP2 7 WWP1 3 affinity chromatography technology, affinity chromatography technology Chaudhary N (2014), Chaudhary N (2014) 2
SMURF1 4 ANKRD13A 1 enzymatic study Andrews PS (2010) 1
LDLRAD4 1 MAGI1 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
SMURF2 3 SMURF1 4 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017) 4
SMURF1 4 EPN1 4 enzymatic study Andrews PS (2010) 1
LDLRAD4 1 NCAPH2 4 affinity chromatography technology Huttlin EL (2015) 1
LDLRAD4 1 NCAPD3 6 affinity chromatography technology Huttlin EL (2015) 1
ACVR2B 0 SMAD2 5 affinity chromatography technology Miura S (2000) 1
LDLRAD4 1 CSNK1E 0 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
LDLRAD4 1 FLCN 1 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
RNF31 3 RBCK1 0 affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017) 21
NEDD4 2 SMURF2 3 affinity chromatography technology, affinity chromatography technology Kuratomi G (2005), Huttlin EL (2017) 2
YAP1 0 SMAD2 5 affinity chromatography technology Pefani DE (2016) 1
LDLRAD4 1 UBR3 13 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
SMAD2 5 CSNK1D 3 affinity chromatography technology, affinity chromatography technology, enzymatic study Brown KA (2008), Ding L (2009), Ding L (2009) 3
LDLRAD4 1 ACVR2A 0 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
LDLRAD4 1 ITCH 1 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
WWOX 3 SMAD3 1 pull down, affinity chromatography technology Ferguson BW (2013), Ferguson BW (2013) 2
SMAD2 5 NEDD4 2 affinity chromatography technology, affinity chromatography technology Kuratomi G (2005), Kuratomi G (2005) 2
SMURF1 4 ANKRD13D 4 enzymatic study Andrews PS (2010) 1
SMAD3 1 WWP1 3 affinity chromatography technology, affinity chromatography technology, two hybrid Komuro A (2004), Seo SR (2004), Rolland T (2014) 3
RNF31 3 SMAD3 1 affinity chromatography technology, two hybrid Wang J (2011), Wang J (2011) 2
ITCH 1 TAX1BP1 3 affinity chromatography technology, affinity chromatography technology Shembade N (2008), Shembade N (2008) 2
LDLRAD4 1 HECW1 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
SMAD2 5 WWP1 3 affinity chromatography technology, affinity chromatography technology Komuro A (2004), Seo SR (2004) 2
ITCH 1 WWP1 3 affinity chromatography technology OConnor HF (2015) 1
SMAD2 5 SMURF2 3 two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Runyan CE (2009), Runyan CE (2009), Chong PA (2010), Brown KA (2008), Colland F (2004), Colland F (2004), Zhang Y (2017), Zhou F (2017), Zhou F (2017) 16
LDLRAD4 1 SMAD3 1 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
LDLRAD4 1 ANKRD13D 4 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
NEDD4L 3 CUEDC1 4 enzymatic study, pull down Persaud A (2009), Persaud A (2009) 2
LDLRAD4 1 RBCK1 0 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
SMAD3 1 SMURF2 3 two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Tang LY (2011), Brown KA (2008), Zhang L (2013), Li Y (2017), Zhang Y (2017) 12
LDLRAD4 1 ACVR2B 0 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
SMURF2 3 CUEDC1 4 two hybrid Colland F (2004) 1
LDLRAD4 1 CUEDC1 4 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
LDLRAD4 1 SUFU 2 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
SMAD2 5 WASHC4 0 two hybrid Colland F (2004) 1
LDLRAD4 1 ARFGEF2 9 affinity chromatography technology Huttlin EL (2015) 1
LDLRAD4 1 NEDD4 2 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
SMAD2 5 SMURF1 4 affinity chromatography technology, affinity chromatography technology, two hybrid Komuro A (2004), Ito I (2010), Colland F (2004) 3
LDLRAD4 1 NEDD4L 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
FGFR1 2 NEDD4 2 pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology Persaud A (2011), Persaud A (2011), Persaud A (2009), Persaud A (2014) 4
LDLRAD4 1 VPS18 4 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
LDLRAD4 1 UIMC1 4 affinity chromatography technology Huttlin EL (2017) 1
NEDD4 2 RBCK1 0 pull down Persaud A (2009) 1
LDLRAD4 1 PLCG1 6 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
WWP2 7 SMAD2 5 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Soond SM (2011), Soond SM (2011), Brown KA (2008) 3
LDLRAD4 1 SMURF2 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
SMURF1 4 CSNK1D 3 enzymatic study Andrews PS (2010) 1
LDLRAD4 1 CALCOCO2 0 affinity chromatography technology Huttlin EL (2015) 1
LDLRAD4 1 SMAD2 5 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
YAP1 0 ITCH 1 affinity chromatography technology Levy D (2007) 1
LDLRAD4 1 UBR1 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
SMURF1 4 RBCK1 0 enzymatic study Andrews PS (2010) 1
SMAD3 1 SMURF1 4 affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology Komuro A (2004), Colland F (2004), Li Y (2017), Li Y (2017) 4
FGFR1 2 PLCG1 6 two hybrid, imaging technique, two hybrid, pull down, enzymatic study, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology Xu H (1998), Chen TC (2014), Hu Y (2004), Shi E (1993), Shi E (1993), Bae JH (2009), Bae JH (2009), Bae JH (2009), Browaeys-Poly E (2010), Browaeys-Poly E (2010), Vecchione A (2007) 11
NEDD4 2 CUEDC1 4 enzymatic study, pull down Persaud A (2009), Persaud A (2009) 2
HECW2 13 HECW1 3 affinity chromatography technology Lu L (2013) 1
WWP2 7 SMAD3 1 affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid Soond SM (2011), Soond SM (2011), Soond SM (2011), Brown KA (2008), Soond SM (2013), Yu H (2011) 6
LDLRAD4 1 FGFR1 2 affinity chromatography technology Huttlin EL (2015) 1
LDLRAD4 1 DPY19L1 0 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
LDLRAD4 1 WWC2 6 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
LDLRAD4 1 WASHC4 0 affinity chromatography technology Huttlin EL (2017) 1
SMAD3 1 SMAD2 5 affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017) 12
SMAD3 1 YAP1 0 affinity chromatography technology Alarcon C (2009) 1
NEDD4 2 ANKRD13D 4 enzymatic study Persaud A (2009) 1
LDLRAD4 1 CMTR1 3 affinity chromatography technology Huttlin EL (2015) 1
LDLRAD4 1 HECW2 13 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
LDLRAD4 1 WWP2 7 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
LDLRAD4 1 WWOX 3 affinity chromatography technology Huttlin EL (2015) 1
LDLRAD4 1 WWP1 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
NCAPH2 4 NCAPD3 6 affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Onn I (2007), Ono T (2003), Ono T (2003), Wan C (2015), Hein MY (2015), Li W (2015), Huttlin EL (2017) 7
LDLRAD4 1 USP22 1 affinity chromatography technology Huttlin EL (2017) 1
LDLRAD4 1 USP33 1 affinity chromatography technology Huttlin EL (2015) 1
LDLRAD4 1 DHX38 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
WWP2 7 ITCH 1 affinity chromatography technology Chaudhary N (2014) 1
LDLRAD4 1 ANKRD13A 1 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
LDLRAD4 1 CSNK1D 3 affinity chromatography technology Huttlin EL (2015) 1
ITCH 1 SMAD2 5 enzymatic study, affinity chromatography technology Bai Y (2004), Bai Y (2004) 2
LDLRAD4 1 TAX1BP1 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
NEDD4 2 CSNK1D 3 affinity chromatography technology Liu J (2014) 1
SMURF1 4 CUEDC1 4 enzymatic study Andrews PS (2010) 1
LDLRAD4 1 EPN1 4 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
LDLRAD4 1 MAGI3 1 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
CSNK1E 0 CSNK1D 3 affinity chromatography technology, affinity chromatography technology Varjosalo M (2013), Huttlin EL (2017) 2
LDLRAD4 1 YAP1 0 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
CALCOCO2 0 TAX1BP1 3 affinity chromatography technology, two hybrid Morriswood B (2007), Morriswood B (2007) 2
LDLRAD4 1 STXBP4 0 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
LDLRAD4 1 SMURF1 4 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
ITCH 1 SMAD3 1 pull down Feng L (2004) 1
SMAD2 5 NEDD4L 3 affinity chromatography technology, two hybrid, pull down, affinity chromatography technology Gao S (2009), Colland F (2004), Gao S (2009), Yan X (2016) 4
LDLRAD4 1 RTFDC1 0 affinity chromatography technology Huttlin EL (2015) 1
WWOX 3 ITCH 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Abu-Odeh M (2014), Abu-Odeh M (2014), Abu-Odeh M (2014) 3
SMAD3 1 CSNK1D 3 affinity chromatography technology, affinity chromatography technology, enzymatic study Brown KA (2008), Ding L (2009), Ding L (2009) 3
LDLRAD4 1 TOMM40 1 affinity chromatography technology Huttlin EL (2015) 1
LDLRAD4 1 KIDINS220 4 affinity chromatography technology Huttlin EL (2015) 1
NEDD4L 3 SMAD3 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology Gao S (2009), Gao S (2009), Aragon E (2012), Herhaus L (2013), Gao S (2009), Gao S (2009), Yan X (2016) 7
SMAD3 1 NEDD4 2 affinity chromatography technology, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down Kuratomi G (2005), Persaud A (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011) 6
LDLRAD4 1 RNF31 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2