PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAZ	1	MDM4	0	affinity chromatography technology, affinity chromatography technology	Lopez-Pajares V (2008), Huttlin EL (2017)	2
HDAC5	4	YWHAE	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Grozinger CM (2000), Greco TM (2011), Joshi P (2013), Greco TM (2011), Lee CW (2014)	5
HDAC5	4	YWHAZ	1	affinity chromatography technology, affinity chromatography technology	Greco TM (2011), Joshi P (2013)	2
YWHAE	0	USP8	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Gloeckner CJ (2007), Choudhary C (2009), Ma ZY (2015), Reincke M (2015), Reincke M (2015)	5
HDAC4	10	YWHAH	0	affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Hein MY (2015)	2
HDAC7	4	YWHAE	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margariti A (2010), Margariti A (2010), Parra M (2007), Parra M (2007), Gloeckner CJ (2007), Joshi P (2013)	6
HDAC7	4	HDAC5	4	pull down	Dressel U (2001)	1
YWHAE	0	HDAC4	10	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miska EA (2001), Grozinger CM (2000), Bandyopadhyay S (2010), Gloeckner CJ (2007), Joshi P (2013), Choudhary C (2009)	6
YWHAZ	1	RAF1	3	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Clark GJ (1997), Tzivion G (2000), Tzivion G (2000), Koyama S (1995), Koyama S (1995), Van Der Hoeven PC (2000), Chow CW (2000), Andersen SD (2012), Subramanian RR (2001), Wang H (1998), Wang H (1998), Wang H (1998), Dougherty MK (2005), Rajalingam K (2005), Zhu J (2005), So J (2015), Powell DW (2003), Ivanov AA (2017)	18
HDAC5	4	YWHAH	0	affinity chromatography technology, affinity chromatography technology	Greco TM (2011), Joshi P (2013)	2
BAD	1	YWHAE	0	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid	Hsu SY (1997), Bandyopadhyay S (2010), Subramanian RR (2001), Gloeckner CJ (2007), Wang J (2011)	5
YWHAZ	1	BAD	1	pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang H (2001), Yang H (2001), Bandyopadhyay S (2010), Liang X (2010), Subramanian RR (2001), Polzien L (2009), Wang J (2011), Jin L (2009), Mortenson JB (2015), Dong S (2007)	10
HDAC7	4	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margariti A (2010), Margariti A (2010), Joshi P (2013)	3
BAD	1	YWHAH	0	two hybrid, pull down, two hybrid	Hsu SY (1997), Subramanian RR (2001), Wang J (2011)	3
HDAC7	4	YWHAH	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margariti A (2010), Margariti A (2010), Joshi P (2013), Hein MY (2015)	4
YWHAE	0	MDM4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	LeBron C (2006), Okamoto K (2005), Okamoto K (2005), Lopez-Pajares V (2008), Lopez-Pajares V (2008)	5
RAF1	3	YWHAE	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vincenz C (1996), Conklin DS (1995), Subramanian RR (2001), Gloeckner CJ (2007), Rajalingam K (2005), Zhu J (2005), Choudhary C (2009), Choudhary C (2009), So J (2015)	9
HDAC5	4	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Backs J (2008), Backs J (2008), Rui J (2012), Rui J (2012)	4
YWHAZ	1	YWHAH	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Hein MY (2015)	4
YWHAZ	1	HDAC4	10	pull down, affinity chromatography technology	Miska EA (2001), Joshi P (2013)	2
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
YWHAH	0	MDM4	0	affinity chromatography technology	LeBron C (2006)	1
RAF1	3	BAD	1	enzymatic study, enzymatic study, imaging technique	Jin S (2005), Polzien L (2009), Chen TC (2014)	3
YWHAZ	1	USP8	7	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
HDAC7	4	HDAC4	10	pull down	Dressel U (2001)	1
YWHAH	0	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ichimura T (2002), Van Der Hoeven PC (2000), Vincenz C (1996), Subramanian RR (2001), Rajalingam K (2005), Zhu J (2005), So J (2015), Hein MY (2015), Hein MY (2015)	9