PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PHF8	6	ZNF711	2	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kleine-Kohlbrecher D (2010), Kleine-Kohlbrecher D (2010), Kleine-Kohlbrecher D (2010), Kleine-Kohlbrecher D (2010)	4
ZNF711	2	CUL3	17	affinity chromatography technology	Rutz N (2015)	1
HIST1H3A	3	ZNF711	2	bioid	Lambert JP (2015)	1
KCTD5	0	ZNF711	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rutz N (2015), Rutz N (2015), Rutz N (2015)	3
HIST1H3A	3	PHF8	6	pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, enzymatic study	Feng W (2010), Feng W (2010), Kleine-Kohlbrecher D (2010), Kleine-Kohlbrecher D (2010), Qi HH (2010), Qiu J (2010), Qiu J (2010), Qiu J (2010), Zhu Z (2010), Fortschegger K (2010), Fortschegger K (2010), Fortschegger K (2010)	12
KCTD5	0	CUL3	17	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down	Bayon Y (2008), Bayon Y (2008), Bennett EJ (2010), Balasco N (2014), Ji AX (2016), Pinkas DM (2017)	6