PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CBX3	1	TRIM28	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Bandyopadhyay S (2010), Ryan RF (1999), Higo S (2010), Rosnoblet C (2011), Vermeulen M (2010), Hauri S (2016)	7
ZNF10	0	TRIM24	1	two hybrid	Moosmann P (1996)	1
TRIM28	1	TRIM24	1	fluorescent resonance energy transfe	Germain-Desprez D (2003)	1
ZNF10	0	TRIM28	1	two hybrid, pull down, biochemical, pull down, pull down, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, two hybrid, pull down	Moosmann P (1996), Peng H (2000), Peng H (2000), Losson R (2010), Frietze S (2010), Peng H (2007), Peng H (2007), Friedman JR (1996), Peng H (2000), Peng H (2000), Venturini L (1999), Peng H (2000)	12
ZNF10	0	ZNF274	3	biochemical	Peng H (2007)	1
ZNF274	3	TRIM28	1	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Frietze S (2010), Frietze S (2010), Frietze S (2010), Frietze S (2010), Addison JB (2015), Huttlin EL (2017)	6
ZNF10	0	CBX3	1	pull down	Losson R (2010)	1
NDEL1	2	ZNF10	0	two hybrid	Camargo LM (2007)	1