PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
ZNF148	4	GLRX3	1	two hybrid	Rolland T (2014)	1
KRT31	0	GLRX3	1	two hybrid	Rolland T (2014)	1
NFATC2	1	ZNF148	4	affinity chromatography technology	Gabriel CH (2016)	1
KRT31	0	CEP70	1	two hybrid	Rolland T (2014)	1
EP300	36	UBC	7	enzymatic study, affinity chromatography technology	Delvecchio M (2013), Kirilyuk A (2012)	2
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TRRAP	31	TP53	0	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Ard PG (2002), Ard PG (2002), Ard PG (2002), Gamper AM (2008)	4
UBC	7	ZNF148	4	pull down	Nathan JA (2013)	1
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
ZNF148	4	ZNF316	1	biochemical	Havugimana PC (2012)	1
TP53	0	ZNF148	4	affinity chromatography technology, pull down	Bai L (2001), Bai L (2001)	2
ZNF148	4	DEUP1	0	two hybrid	Rolland T (2014)	1
ZNF148	4	CEP70	1	two hybrid	Rolland T (2014)	1
ACTR5	1	ZNF148	4	affinity chromatography technology	Hein MY (2015)	1
FOXJ2	3	ZNF148	4	affinity chromatography technology	Li X (2015)	1
KRT31	0	ZNF148	4	two hybrid	Rolland T (2014)	1
ZNF148	4	EP300	36	affinity chromatography technology	Woo AJ (2011)	1
ELAVL1	0	FOXJ2	3	affinity chromatography technology	Abdelmohsen K (2009)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
ZNF148	4	KAT2A	1	affinity chromatography technology	Woo AJ (2011)	1
NFATC2	1	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Garcia-Rodriguez C (1998), Garcia-Rodriguez C (1998), Gabriel CH (2016), Gabriel CH (2016)	4
IL16	2	HDAC3	5	pull down, affinity chromatography technology	Zhang Y (2008), Zhang Y (2008)	2
ZNF148	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology, imaging technique	Feng Y (2009), Feng Y (2009), Feng Y (2009)	3
ELAVL1	0	CAVIN1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	ZNF148	4	affinity chromatography technology	Abdelmohsen K (2009)	1
EP300	36	HDAC3	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kadeppagari RK (2009), Gregoire S (2007), Gregoire S (2007), Sankar N (2008), Sankar N (2008)	5
HDAC1	4	ZNF148	4	affinity chromatography technology	Wu Y (2007)	1
ZNF148	4	CAVIN1	0	two hybrid, pull down	Hasegawa T (2000), Hasegawa T (2000)	2
NFATC2	1	HDAC1	4	affinity chromatography technology	Gabriel CH (2016)	1
TRIM25	5	ZNF148	4	affinity chromatography technology	Choudhury NR (2017)	1
KAT2A	1	TRRAP	31	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McMahon SB (2000), Helmlinger D (2006), Meyer KD (2008), Krebs AR (2010), Kim J (2010), Kim J (2010), Liu X (2003)	7
IL16	2	ZNF148	4	affinity chromatography technology	Huttlin EL (2017)	1
SIAH1	2	ZNF148	4	two hybrid	Rolland T (2014)	1
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
CLK1	1	ZNF148	4	enzymatic study	Lipp JJ (2015)	1
UBC	7	CAVIN1	0	pull down	Zhang X (2017)	1
ZNF148	4	TRIM10	3	two hybrid	Rolland T (2014)	1
ZNF148	4	TRRAP	31	affinity chromatography technology	Woo AJ (2011)	1
ZNF148	4	NUTM2F	0	two hybrid	Rolland T (2014)	1
NOC4L	3	ZNF148	4	biochemical	Havugimana PC (2012)	1
NFATC2	1	TRRAP	31	affinity chromatography technology	Gabriel CH (2016)	1
TP53	0	KAT2A	1	affinity chromatography technology, fluorescent resonance energy transfe	Gamper AM (2008), Ivanov AA (2017)	2
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
ZNF148	4	GORASP2	1	two hybrid	Rolland T (2014)	1
TRIM25	5	GLRX3	1	affinity chromatography technology	Choudhury NR (2017)	1