PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZNF250	2	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
ZNF165	1	ZNF24	1	two hybrid	Williams AJ (1999)	1
ZNF165	1	ELOA2	0	two hybrid	Rual JF (2005)	1
GPATCH2L	1	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
DVL2	5	ELOA2	0	two hybrid	Rual JF (2005)	1
ZNF24	1	CCDC130	1	two hybrid	Rual JF (2005)	1
ZNF165	1	SCAND1	1	two hybrid	Rual JF (2005)	1
ZNF165	1	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
EWSR1	2	ZNF165	1	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
ZNF165	1	ZNF250	2	two hybrid	Rual JF (2005)	1
EWSR1	2	EMD	0	bioid	Elzi DJ (2014)	1
ZNF165	1	ZNF446	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
ELOA2	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
ZNF165	1	SUV39H1	0	two hybrid	Weimann M (2013)	1
CCDC85B	0	ZNF250	2	two hybrid	Rual JF (2005)	1
ZNF165	1	KRT40	0	two hybrid	Rolland T (2014)	1
DVL2	5	ZNF165	1	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
ZNF165	1	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
ZNF165	1	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
ZNF24	1	MID2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ZNF165	1	CCDC85B	0	two hybrid	Rual JF (2005)	1
ZNF165	1	AHCYL1	2	two hybrid	Rolland T (2014)	1
ZNF250	2	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
DVL2	5	ZNF250	2	two hybrid	Rual JF (2005)	1
ZNF250	2	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
ZNF165	1	FAM124A	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ZNF446	1	KRT40	0	two hybrid	Rolland T (2014)	1
ZNF250	2	KRT40	0	two hybrid	Rolland T (2014)	1
ZNF24	1	ZNF446	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
ZNF24	1	SCAND1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
ZNF165	1	KAT7	3	two hybrid	Rual JF (2005)	1
MID2	1	ZNF250	2	two hybrid	Rolland T (2014)	1
GPATCH2L	1	KRTAP4-12	2	two hybrid	Rolland T (2014)	1
KRTAP10-7	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
ZNF165	1	MID2	1	two hybrid	Rolland T (2014)	1
KRTAP4-12	2	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
ZNF446	1	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
ZNF165	1	GPATCH2L	1	two hybrid	Rolland T (2014)	1
ZNF165	1	PDLIM7	0	two hybrid	Rual JF (2005)	1
ZNF165	1	CCDC130	1	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
ZKSCAN8	0	ZNF165	1	two hybrid, two hybrid	Williams AJ (1999), Williams AJ (1999)	2
GPATCH2L	1	KRT40	0	two hybrid	Rolland T (2014)	1
ZNF250	2	FAM124A	3	two hybrid	Rolland T (2014)	1
SUV39H1	0	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
ZKSCAN8	0	ZNF24	1	two hybrid	Williams AJ (1999)	1
EMD	0	ZNF165	1	two hybrid	Rolland T (2014)	1