Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CACNA1B 774 LEVETIRACETAM CHEMBL1286 inhibitor, blocker TdgClinicalTrial, ChemblInteractions, DrugBank 11879381, 17461889
CACNA1B 774 AGMATINE CHEMBL58343 antagonist DrugBank 12904272
CACNA1B 774 CELECOXIB CHEMBL118 PharmGKB
CACNA1B 774 GABAPENTIN ENACARBIL CHEMBL1628502 modulator TdgClinicalTrial, ChemblInteractions
CACNA1B 774 ELPETRIGINE CHEMBL29919 blocker ChemblInteractions
CACNA1B 774 GABAPENTIN CHEMBL940 inhibitor, modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 20588320, 18299583, 16368827
CACNA1B 774 ZICONOTIDE CHEMBL2103752 blocker TdgClinicalTrial, TTD
CACNA1B 774 ATAGABALIN CHEMBL593430 modulator ChemblInteractions
CACNA1B 774 AMLODIPINE CHEMBL1491 TEND
CACNA1B 774 SAFINAMIDE CHEMBL396778 TdgClinicalTrial
CACNA1B 774 PREGABALIN CHEMBL1059 modulator ChemblInteractions
CACNA1B 774 VERAPAMIL CHEMBL6966 inhibitor DrugBank 19125880
CACNA1B 774 CHEMBL157769 CHEMBL157769 channel blocker GuideToPharmacologyInteractions
CACNA1B 774 CNV2197944 CHEMBL3545172 blocker TdgClinicalTrial, ChemblInteractions
CACNA1B 774 RALFINAMIDE CHEMBL2107771 blocker ChemblInteractions, TTD
CACNA1B 774 CILNIDIPINE CHEMBL452076 blocker TTD
CACNA1B 774 CLEVIDIPINE CHEMBL1237132 TEND
CACNA1B 774 Z160 CHEMBL604710 blocker ChemblInteractions
CACNA1B 774 ZICONOTIDE ACETATE CHEMBL1795072 blocker ChemblInteractions
CACNA1B 774 IMAGABALIN CHEMBL2103836 modulator ChemblInteractions
CACNA1B 774 BEPRIDIL HYDROCHLORIDE CHEMBL1200382 blocker ChemblInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CACNA1B rs2229949 CC antipsychotics efficacy yes Patients with the CC genotype had a greater decrease in Positive and Negative Syndrome Scale (PANSS)-negative scores over a period of 12 months as compared to those with the TT genotype. No significant association was seen when comparing the CT vs TT genotype. Significance was set at p<3.45E-6. Genotype CC is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotype TT. 30032160 1449753246