Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CACNA1E 777 BEPRIDIL HYDROCHLORIDE CHEMBL1200382 blocker ChemblInteractions
CACNA1E 777 CHEMBL157769 CHEMBL157769 channel blocker GuideToPharmacologyInteractions
CACNA1E 777 CELECOXIB CHEMBL118 PharmGKB
CACNA1E 777 GABAPENTIN ENACARBIL CHEMBL1628502 modulator ChemblInteractions
CACNA1E 777 PREGABALIN CHEMBL1059 modulator ChemblInteractions
CACNA1E 777 ATAGABALIN CHEMBL593430 modulator ChemblInteractions
CACNA1E 777 PYRIMETHAMINE CHEMBL36 channel blocker GuideToPharmacologyInteractions
CACNA1E 777 GABAPENTIN CHEMBL940 modulator ChemblInteractions
CACNA1E 777 IMAGABALIN CHEMBL2103836 modulator ChemblInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CACNA1E rs12060765 TT antipsychotics efficacy yes Patients with the TT genotype had a greater decrease in Positive and Negative Syndrome Scale (PANSS)-negative scores over a period of 12 months as compared to those with the GG genotype. No significant association was seen when comparing the GT vs GG genotype. Significance was set at p<3.45E-6. Genotype TT is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotype GG. 30032160 1449753275
CACNA1E rs3845446 TT fentanyl "dosage","efficacy" no A formula was developed to predict individual opioid use during the first 24-h post-operative period for patients who underwent craniofacial surgery. The post-operative period R squared values were higher when genotype information was included. In the first group fentanyl was administered by IV, on demand, with a bolus dose of 20 micrograms and a 10 minute lockout period 24-h post-op. Genotype TT is not associated with dose of fentanyl in people with Pain, Postoperative as compared to genotypes CC + CT. 25615449 1444694036
CACNA1E rs3845446 CC + CT fentanyl dosage yes Subjects carrying the C allele required significantly less intrapoperative and perioperative fentanyl than those not carrying the C allele. However, there was no significant difference in analgesic response to fentanyl between the genotype groups. Please note that alleles have been complemented to the positive strand. Genotypes CC + CT are associated with decreased dose of fentanyl in people with Pain, Postoperative as compared to genotype TT. 23940630 1450820493