PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	MAPK6	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MAP2K7	5	MAPK8IP1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Yasuda J (1999), Yasuda J (1999), Santos CR (2006), Blanco S (2008), Blanco S (2008)	5
HSP90AA1	7	MAP3K12	2	affinity chromatography technology	Taipale M (2012)	1
FTL	0	MAP3K12	2	two hybrid	Stelzl U (2005)	1
MBIP	0	MAP3K12	2	two hybrid, affinity chromatography technology	Fukuyama K (2000), Fukuyama K (2000)	2
EGFR	5	MAPK8IP1	7	unspecified method	Jones RB (2006)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
RGS1	1	MAP3K12	2	two hybrid	Stelzl U (2005)	1
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
RGS1	1	TSC22D1	1	two hybrid	Stelzl U (2005)	1
MAP3K12	2	MAPK8IP1	7	affinity chromatography technology, pull down	Yasuda J (1999), Yasuda J (1999)	2
ELAVL1	0	MAP3K12	2	affinity chromatography technology	Abdelmohsen K (2009)	1
MAPK6	1	MAP3K12	2	two hybrid	Vinayagam A (2011)	1
HNRNPL	3	MAP3K12	2	affinity chromatography technology	Fei T (2017)	1
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
HNRNPL	3	TSC22D1	1	affinity chromatography technology	Fei T (2017)	1
TSC22D1	1	MAP3K12	2	two hybrid	Stelzl U (2005)	1
HSP90AA1	7	MAP2K7	5	affinity chromatography technology	Taipale M (2012)	1
MAP3K12	2	MAP2K7	5	enzymatic study, affinity chromatography technology	Merritt SE (1999), Merritt SE (1999)	2
HNRNPL	3	MAPK6	1	affinity chromatography technology	Fei T (2017)	1
EGFR	5	MAP3K12	2	protein complementation assay, affinity chromatography technology	Deribe YL (2009), Deribe YL (2009)	2
ELAVL1	0	MAP2K7	5	affinity chromatography technology	Abdelmohsen K (2009)	1
MAP2K7	5	MAPK8IP2	5	affinity chromatography technology, pull down, pull down, pull down	Yasuda J (1999), Yasuda J (1999), Yasuda J (1999), Negri S (2000)	4
EGFR	5	MAPK8IP2	5	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
MAPK8IP1	7	MAPK8IP2	5	affinity chromatography technology, pull down, affinity chromatography technology	Yasuda J (1999), Yasuda J (1999), Huttlin EL (2017)	3
MAPK6	1	MBIP	0	two hybrid	Wang J (2011)	1
MAP3K12	2	MAPK8IP2	5	affinity chromatography technology, pull down	Yasuda J (1999), Yasuda J (1999)	2
FRA10AC1	0	MAP3K12	2	pull down	Stelzl U (2005)	1