Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CACNB2 783 ISRADIPINE CHEMBL1648 inhibitor DrugBank 11752352
CACNB2 783 FELODIPINE CHEMBL1480 inhibitor TdgClinicalTrial, DrugBank 11752352, 10525060, 17475903
CACNB2 783 SALSALATE CHEMBL154111 inhibitor GuideToPharmacologyInteractions
CACNB2 783 CELECOXIB CHEMBL118 PharmGKB
CACNB2 783 IMAGABALIN CHEMBL2103836 modulator ChemblInteractions
CACNB2 783 NISOLDIPINE CHEMBL1726 inhibitor DrugBank 11752352
CACNB2 783 NITRENDIPINE CHEMBL475534 inhibitor DrugBank 11752352
CACNB2 783 PREGABALIN CHEMBL1059 modulator ChemblInteractions
CACNB2 783 GABAPENTIN CHEMBL940 modulator ChemblInteractions
CACNB2 783 ATAGABALIN CHEMBL593430 modulator ChemblInteractions
CACNB2 783 NIMODIPINE CHEMBL1428 inhibitor DrugBank 11752352, 19844625, 20661350, 20334460, 17705883
CACNB2 783 NIFEDIPINE CHEMBL193 inhibitor DrugBank 11752352
CACNB2 783 AMLODIPINE CHEMBL1491 TdgClinicalTrial
CACNB2 783 BEPRIDIL HYDROCHLORIDE CHEMBL1200382 blocker ChemblInteractions
CACNB2 783 MAGNESIUM SULFATE CHEMBL1200456 DrugBank 17139284, 17016423
CACNB2 783 VERAPAMIL CHEMBL6966 inhibitor TdgClinicalTrial, TEND, DrugBank 19125880
CACNB2 783 DRONEDARONE CHEMBL184412 DrugBank
CACNB2 783 GABAPENTIN ENACARBIL CHEMBL1628502 modulator ChemblInteractions
CACNB2 783 MIBEFRADIL CHEMBL45816 inhibitor DrugBank 10372226, 10665814, 16899990
CACNB2 783 NILVADIPINE CHEMBL517427 inhibitor DrugBank 1283184, 20933604, 7898101

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CACNB2 rs4237348 CC antipsychotics efficacy yes Patients with the CC genotype had a greater decrease in Positive and Negative Syndrome Scale (PANSS)-positive scores over a period of 12 months as compared to those with the CT genotype. No significant association was seen when comparing the CC vs TT genotype. Significance was set at p<3.45E-6. Genotype CC is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotype CT. 30032160 1449753418
CACNB2 rs12245847 TT antipsychotics efficacy yes Patients with the TT genotype had a greater decrease in Positive and Negative Syndrome Scale (PANSS)-negative scores over a period of 12 months as compared to those with the CT genotype. No significant association was seen when comparing the CC vs TT genotype. Significance was set at p<3.45E-6. Genotype TT is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotype CT. 30032160 1449753382
CACNB2 rs982003 CC antipsychotics efficacy yes Patients with the CC genotype had a greater decrease in Positive and Negative Syndrome Scale (PANSS)-negative scores over a period of 12 months as compared to those with the TT genotype. No significant association was seen when comparing the CT vs TT genotype. Significance was set at p<3.45E-6. Please note that alleles have been complemented to the plus chromosomal strand. Genotype CC is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotype TT. 30032160 1449753373
CACNB2 rs1277733 TT antipsychotics efficacy yes Patients with the TT genotype had a greater decrease in Positive and Negative Syndrome Scale (PANSS)-general scores over a period of 12 months as compared to those with the CC genotype. No significant association was seen when comparing the CT vs TT genotype. Significance was set at p<3.45E-6. Please note that alleles have been complemented to the plus chromosomal strand. Genotype TT is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotype CC. 30032160 1449753409
CACNB2 rs10741058 TT antipsychotics efficacy yes Patients with the TT genotype had a greater decrease in Positive and Negative Syndrome Scale (PANSS)-negative scores over a period of 12 months as compared to those with the CC genotype. No significant association was seen when comparing the CT vs CC genotype. Significance was set at p<3.45E-6. Genotype TT is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotype CC. 30032160 1449753301