PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CRYL1	0	ALMS1	13	affinity chromatography technology	Huttlin EL (2017)	1
CEP128	1	AMOT	6	bioid	Gupta GD (2015)	1
CNTROB	6	CEP192	5	bioid	Gupta GD (2015)	1
CENPJ	6	ALMS1	13	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
LATS2	1	ALMS1	13	bioid	Couzens AL (2013)	1
AVIL	0	ALMS1	13	affinity chromatography technology	Huttlin EL (2017)	1
CEP135	2	KIAA0753	1	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
BRCA1	7	ALMS1	13	affinity chromatography technology	Ertych N (2016)	1
ODF2	1	CEP192	5	bioid	Gupta GD (2015)	1
SASS6	1	ALMS1	13	bioid	Gupta GD (2015)	1
ODF2	1	KIAA0753	1	bioid	Gupta GD (2015)	1
MED4	2	AMOT	6	two hybrid, affinity chromatography technology	Rolland T (2014), Lambert JP (2015)	2
CEP120	5	MED4	2	bioid	Gupta GD (2015)	1
MED4	2	KIAA0753	1	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
KIAA0753	1	POC5	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
BRCA1	7	SKP2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lu Y (2012), Lu Y (2012), Parameswaran B (2015)	3
LATS2	1	CEP192	5	bioid	Couzens AL (2013)	1
SKAP1	0	NCAPH2	4	affinity chromatography technology	Huttlin EL (2015)	1
CEP135	2	CEP152	2	bioid	Gupta GD (2015)	1
LATS2	1	CENPJ	6	bioid	Couzens AL (2013)	1
CEP192	5	ALMS1	13	affinity chromatography technology, bioid	Gomez-Ferreria MA (2012), Firat-Karalar EN (2014)	2
POC5	5	CEP192	5	bioid	Gupta GD (2015)	1
ODF2	1	ALMS1	13	bioid	Gupta GD (2015)	1
POC5	5	CEP152	2	bioid	Gupta GD (2015)	1
LACC1	0	ALMS1	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	CDC16	2	affinity chromatography technology	Hill SJ (2014)	1
HSPB8	0	ALMS1	13	affinity chromatography technology	Huttlin EL (2017)	1
POC5	5	MED4	2	bioid	Gupta GD (2015)	1
PLK4	1	CEP128	1	bioid	Firat-Karalar EN (2014)	1
DNM3	3	ALMS1	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
THSD4	1	MLF1	2	affinity chromatography technology	Huttlin EL (2017)	1
DEF8	4	ALMS1	13	affinity chromatography technology	Huttlin EL (2017)	1
LIG4	0	ALMS1	13	two hybrid, affinity chromatography technology	Woods NT (2012), Woods NT (2012)	2
CEP152	2	ALMS1	13	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
POC5	5	ALMS1	13	bioid	Gupta GD (2015)	1
CENPJ	6	CEP192	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
TRIM25	5	DEF8	4	affinity chromatography technology	Choudhury NR (2017)	1
LATS2	1	CDC16	2	affinity chromatography technology	Zhu C (2018)	1
ODF2	1	CEP135	2	bioid	Gupta GD (2015)	1
TRIM25	5	SKP2	2	affinity chromatography technology	Choudhury NR (2017)	1
LATS2	1	AMOT	6	affinity chromatography technology, bioid, enzymatic study, enzymatic study, enzymatic study	Couzens AL (2013), Couzens AL (2013), Adler JJ (2013), Chan SW (2013), Dai X (2013)	5
CEP120	5	CNTROB	6	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
MED4	2	CEP152	2	bioid	Lambert JP (2015)	1
CEP135	2	CEP192	5	bioid	Gupta GD (2015)	1
CEP135	2	CEP97	0	bioid	Gupta GD (2015)	1
MED4	2	TRIM25	5	bioid	Lambert JP (2015)	1
CEP128	1	CEP120	5	bioid	Gupta GD (2015)	1
CEP120	5	CEP152	2	bioid	Gupta GD (2015)	1
SASS6	1	CEP152	2	bioid	Gupta GD (2015)	1
NCAPH2	4	ALMS1	13	affinity chromatography technology	Huttlin EL (2017)	1
CDC16	2	ALMS1	13	affinity chromatography technology	Huttlin EL (2017)	1
PLK4	1	ALMS1	13	bioid	Firat-Karalar EN (2014)	1
CENPJ	6	CEP97	0	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
PLK4	1	CEP192	5	bioid	Firat-Karalar EN (2014)	1
MUS81	1	ALMS1	13	genetic interference	Vizeacoumar FJ (2013)	1
CEP63	2	ALMS1	13	bioid	Firat-Karalar EN (2014)	1
MED4	2	CNTROB	6	bioid	Lambert JP (2015)	1
CEP135	2	ALMS1	13	bioid	Gupta GD (2015)	1
TFDP3	0	ALMS1	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP128	1	CEP192	5	bioid	Gupta GD (2015)	1
DKK3	3	ALMS1	13	affinity chromatography technology	Huttlin EL (2017)	1
CEP128	1	CNTROB	6	bioid	Gupta GD (2015)	1
CEP120	5	CEP97	0	bioid	Gupta GD (2015)	1
CEP192	5	CEP152	2	bioid, bioid, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	3
TRIM25	5	GTF2IRD1	6	affinity chromatography technology	Choudhury NR (2017)	1
GAN	4	ALMS1	13	affinity chromatography technology	Johnson-Kerner BL (2015)	1
CEP63	2	CEP128	1	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
MLF1	2	ALMS1	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MED4	2	CEP135	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
AMOT	6	ALMS1	13	bioid	Couzens AL (2013)	1
GTF2IRD1	6	ALMS1	13	two hybrid	Carmona-Mora P (2015)	1
CEP152	2	CEP128	1	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
TRIM25	5	SRPK2	1	affinity chromatography technology	Choudhury NR (2017)	1
AARSD1	0	ALMS1	13	affinity chromatography technology	Huttlin EL (2017)	1
CEP128	1	MED4	2	bioid	Gupta GD (2015)	1
CNTROB	6	ALMS1	13	bioid	Gupta GD (2015)	1
BRCA1	7	GTF2IRD1	6	affinity chromatography technology	Hill SJ (2014)	1
SKAP1	0	ALMS1	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SKP2	2	ALMS1	13	affinity chromatography technology	Huttlin EL (2017)	1
ODF2	1	CEP97	0	bioid	Gupta GD (2015)	1
CEP97	0	ALMS1	13	bioid	Gupta GD (2015)	1
CEP128	1	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
SASS6	1	CENPJ	6	bioid	Gupta GD (2015)	1
SRPK2	1	ALMS1	13	affinity chromatography technology	Varjosalo M (2013)	1
SASS6	1	CEP97	0	bioid	Gupta GD (2015)	1
RABL2A	0	ALMS1	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BTRC	1	ALMS1	13	bioid	Coyaud E (2015)	1
CEP128	1	ALMS1	13	bioid	Gupta GD (2015)	1
CENPJ	6	KIAA0753	1	bioid	Gupta GD (2015)	1
CEP120	5	CEP192	5	bioid	Gupta GD (2015)	1
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
ODF2	1	CEP120	5	bioid	Gupta GD (2015)	1
BRCA1	7	TRIM25	5	affinity chromatography technology	Ertych N (2016)	1
CEP63	2	KIAA0753	1	bioid, bioid, affinity chromatography technology, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	4
AARSD1	0	POC5	5	affinity chromatography technology	Huttlin EL (2017)	1
KIAA0753	1	ALMS1	13	bioid	Firat-Karalar EN (2014)	1
CENPJ	6	CEP120	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CEP128	1	LATS2	1	bioid	Gupta GD (2015)	1
CEP192	5	CEP63	2	bioid, bioid, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	3
CEP128	1	CEP97	0	bioid	Gupta GD (2015)	1
KIAA0753	1	CEP120	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
GPRASP2	0	ALMS1	13	affinity chromatography technology	Li S (2014)	1
AARSD1	0	MLF1	2	affinity chromatography technology	Huttlin EL (2017)	1
DTNBP1	1	ALMS1	13	affinity chromatography technology	Huttlin EL (2015)	1
BTRC	1	PLK4	1	affinity chromatography technology, affinity chromatography technology	Guderian G (2010), Guderian G (2010)	2
TRIM25	5	BTRC	1	affinity chromatography technology	Choudhury NR (2017)	1
MED4	2	ALMS1	13	bioid	Lambert JP (2015)	1
CDC16	2	MLF1	2	affinity chromatography technology	Huttlin EL (2017)	1
POC5	5	CEP128	1	bioid	Gupta GD (2015)	1
SKP2	2	BTRC	1	affinity chromatography technology, pull down, affinity chromatography technology	Wei S (2012), Wei S (2012), Wei S (2012)	3
AARSD1	0	SASS6	1	affinity chromatography technology	Huttlin EL (2017)	1
CEP63	2	MED4	2	bioid	Gupta GD (2015)	1
CEP120	5	ALMS1	13	bioid	Gupta GD (2015)	1
BBS7	2	ALMS1	13	affinity chromatography technology	Huttlin EL (2017)	1
BTRC	1	GPRASP2	0	affinity chromatography technology	Sowa ME (2009)	1
CEP152	2	KIAA0753	1	bioid, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014)	2
CDC16	2	CEP97	0	affinity chromatography technology	Huttlin EL (2017)	1
CEP104	4	ALMS1	13	bioid	Gupta GD (2015)	1
TRIM25	5	ALMS1	13	affinity chromatography technology	Choudhury NR (2017)	1
SKP2	2	CEP192	5	affinity chromatography technology	Moser SC (2013)	1
THSD4	1	ALMS1	13	affinity chromatography technology	Huttlin EL (2017)	1
PLK4	1	CEP152	2	bioid, bioid, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Hein MY (2015)	3
AMOT	6	CNTROB	6	bioid	Couzens AL (2013)	1
PLK4	1	SASS6	1	bioid	Firat-Karalar EN (2014)	1
SASS6	1	CEP192	5	bioid	Gupta GD (2015)	1
SASS6	1	MED4	2	bioid	Gupta GD (2015)	1
CEP63	2	CEP152	2	bioid, bioid, bioid, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	4
CEP152	2	CENPJ	6	bioid	Firat-Karalar EN (2014)	1
C6orf141	1	ALMS1	13	affinity chromatography technology	Huttlin EL (2017)	1
ODF2	1	BRCA1	7	imaging technique	Tarapore P (2012)	1
CEP128	1	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
PLK4	1	CEP63	2	bioid	Firat-Karalar EN (2014)	1
LATS2	1	CNTROB	6	bioid	Couzens AL (2013)	1
CEP97	0	CEP104	4	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	CEP120	5	bioid	Gupta GD (2015)	1
LATS2	1	SKP2	2	affinity chromatography technology	Couzens AL (2013)	1
MED4	2	ODF2	1	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2