Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CACNB4 785 VERAPAMIL CHEMBL6966 inhibitor TdgClinicalTrial, TEND, DrugBank 19125880
CACNB4 785 DRONEDARONE CHEMBL184412 DrugBank
CACNB4 785 BEPRIDIL HYDROCHLORIDE CHEMBL1200382 blocker ChemblInteractions
CACNB4 785 GABAPENTIN CHEMBL940 modulator ChemblInteractions
CACNB4 785 GABAPENTIN ENACARBIL CHEMBL1628502 modulator ChemblInteractions
CACNB4 785 ATAGABALIN CHEMBL593430 modulator ChemblInteractions
CACNB4 785 SAFINAMIDE CHEMBL396778 TdgClinicalTrial
CACNB4 785 NIMODIPINE CHEMBL1428 inhibitor DrugBank 20335610, 19844625, 20661350, 20334460, 17705883
CACNB4 785 PREGABALIN CHEMBL1059 modulator ChemblInteractions
CACNB4 785 IMAGABALIN CHEMBL2103836 modulator ChemblInteractions
CACNB4 785 CELECOXIB CHEMBL118 PharmGKB
CACNB4 785 MIBEFRADIL CHEMBL45816 inhibitor DrugBank 10372226, 10665814, 16899990

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CACNB4 rs3768652 AA + AC antipsychotics efficacy yes Patients with the AA and AC genotype had a greater decrease in Positive and Negative Syndrome Scale (PANSS)-negative scores over a period of 12 months as compared to those with the CC genotype. Significance was set at p<3.45E-6. Please note that alleles have been complemented to the plus chromosomal strand. Genotypes AA + AC is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotype CC. 30032160 1449753427