PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTPN7	3	MAPKAPK3	0	affinity chromatography technology	Li X (2016)	1
MAPK11	1	MAPKAPK3	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
PTPN7	3	APP	1	pull down	Olah J (2011)	1
MAPKAPK3	0	5616	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPKAPK3	0	MAPK14	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Tanoue T (2001), Tanoue T (2001), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Vogl T (2004), Huttlin EL (2017)	10
THAP12	0	MAPKAPK3	0	two hybrid, affinity chromatography technology	Luig C (2010), Luig C (2010)	2
MAPKAPK3	0	APP	1	pull down	Olah J (2011)	1
NEDD4	2	MAPKAPK3	0	enzymatic study	Persaud A (2009)	1
PTPRR	3	MAPKAPK3	0	affinity chromatography technology	Li X (2016)	1
MAPK11	1	MAPK14	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Varjosalo M (2013)	2
EZH2	4	HSPB1	2	affinity chromatography technology	Cao Q (2014)	1
MAPKAPK3	0	RCSD1	2	enzymatic study	Eyers CE (2005)	1
BMI1	0	RNF2	1	biochemical, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Cao R (2005), Ben-Saadon R (2006), Li Z (2006), Maertens GN (2009), Wei J (2006), Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Pan MR (2011), Pan MR (2011), Voncken JW (2005), Woodsmith J (2012), Voncken JW (2003), Woodsmith J (2012), Li Z (2006), Li Z (2006), McGinty RK (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Balasubramanian S (2015), Taherbhoy AM (2015), Taherbhoy AM (2015), Abdouh M (2016), Sanchez A (2016), Wheaton K (2017), Hauri S (2016), Hauri S (2016)	30
BECN1	2	NEDD4	2	affinity chromatography technology, pull down, two hybrid, enzymatic study, affinity chromatography technology	Platta HW (2012), Platta HW (2012), Platta HW (2012), Platta HW (2012), Verma N (2017)	5
MEF2A	1	MAPKAPK3	0	affinity chromatography technology	Li X (2015)	1
MAPK14	0	BMI1	0	enzymatic study	Srivastav RK (2011)	1
MAPKAPK3	0	TCF3	7	two hybrid, enzymatic study, pull down	Neufeld B (2000), Neufeld B (2000), Neufeld B (2000)	3
MAPK13	1	MAPKAPK3	0	imaging technique	Chen TC (2014)	1
MAPK14	0	HSPB1	2	enzymatic study	Morley SJ (2000)	1
SRPK2	1	MAPKAPK3	0	enzymatic study	Lipp JJ (2015)	1
MAPKAPK3	0	3507	0	two hybrid	Vinayagam A (2011)	1
MAPKAPK3	0	EZH2	4	two hybrid	Vinayagam A (2011)	1
PTPDC1	3	MAPKAPK3	0	affinity chromatography technology	Li X (2016)	1
MAPKAPK3	0	RAB2A	4	two hybrid	Vinayagam A (2011)	1
BMI1	0	SRPK2	1	affinity chromatography technology	Cao Q (2014)	1
PTPN7	3	MAPK11	1	affinity chromatography technology	Li X (2016)	1
RNF2	1	BECN1	2	affinity chromatography technology	Xia P (2014)	1
MAPKAPK3	0	BECN1	2	enzymatic study	Wei Y (2015)	1
MAPK14	0	5616	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK11	1	APP	1	pull down	Olah J (2011)	1
MAPKAPK3	0	ATF1	0	enzymatic study	Mayo LD (2001)	1
MAPKAPK3	0	SMS	1	two hybrid	Vinayagam A (2011)	1
PTPRR	3	MAPK11	1	affinity chromatography technology	Li X (2016)	1
MAPK13	1	APP	1	pull down	Olah J (2011)	1
PTPN7	3	MAPK14	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), St-Denis N (2016), Li X (2016)	3
SRPK2	1	APP	1	pull down	Olah J (2011)	1
MAPKAPK3	0	COPS6	0	two hybrid	Vinayagam A (2011)	1
PTPRR	3	MAPK14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Li X (2016)	4
RNF2	1	APP	1	affinity chromatography technology	Cao Q (2014)	1
3507	0	APP	1	pull down	Olah J (2011)	1
MAPKAPK3	0	PHC2	3	two hybrid, affinity chromatography technology	Voncken JW (2005), Voncken JW (2005)	2
PTPN5	0	MAPKAPK3	0	affinity chromatography technology	Li X (2016)	1
MAPKAPK3	0	BMI1	0	affinity chromatography technology, affinity chromatography technology	Voncken JW (2005), Voncken JW (2005)	2
BMI1	0	PHC2	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Gunster MJ (1997), Gunster MJ (1997), Gunster MJ (1997), Wei J (2006), Maertens GN (2009), Gao Z (2012), Gao Z (2012), Rolland T (2014), Cao Q (2014), Gray F (2016), Gray F (2016), Hauri S (2016), Hauri S (2016)	13
MAPKAPK3	0	HSPB1	2	enzymatic study, imaging technique	Clifton AD (1996), Chen TC (2014)	2
MAPK14	0	PHC2	3	protein complementation assay	Srivastav RK (2011)	1
MAPKAPK3	0	SUMO3	0	two hybrid	Vinayagam A (2011)	1
RNF2	1	MAPKAPK3	0	affinity chromatography technology	Voncken JW (2005)	1
RNF2	1	PHC2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Voncken JW (2005), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	7
NEDD4L	3	MAPKAPK3	0	enzymatic study	Persaud A (2009)	1
PTPN5	0	MAPK14	0	affinity chromatography technology	Li X (2016)	1
MAPK14	0	MEF2A	1	enzymatic study, enzymatic study	Zhao M (1999), Yang SH (1999)	2