PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CSNK2A2	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Gao Z (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
SLBP	0	DCAF11	2	pull down, affinity chromatography technology, affinity chromatography technology	Djakbarova U (2016), Djakbarova U (2016), Djakbarova U (2016)	3
SLBP	0	CUL4A	2	pull down, affinity chromatography technology, affinity chromatography technology	Djakbarova U (2016), Djakbarova U (2016), Djakbarova U (2016)	3
CCNA2	1	SKP1	0	affinity chromatography technology	Hein MY (2015)	1
CDK4	2	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Ivanov AA (2017)	2
CUL1	7	NCBP1	7	affinity chromatography technology	Bennett EJ (2010)	1
CDK2	0	UPF1	8	affinity chromatography technology	Neganova I (2011)	1
SLBP	0	CSNK2A2	1	affinity chromatography technology	Dankert JF (2016)	1
SLBP	0	CSNK2A1	15	affinity chromatography technology	Dankert JF (2016)	1
SLBP	0	ZNF473	1	two hybrid	Dominski Z (2002)	1
GSTM3	1	SLBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL2	3	FEM1C	2	affinity chromatography technology	Bennett EJ (2010)	1
SLBP	0	CUL2	3	affinity chromatography technology	Dankert JF (2017)	1
CDK4	2	SKP1	0	two hybrid	Wang J (2011)	1
CCNF	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2011), Jeong YT (2013), Choudhury R (2017), Reitsma JM (2017)	4
CDK6	0	SLBP	0	enzymatic study	Anders L (2011)	1
UPF1	8	SLBP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaygun H (2005), Kaygun H (2005), Dankert JF (2017), Dankert JF (2016), Dankert JF (2016)	5
SLBP	0	EIF4G1	9	affinity chromatography technology, affinity chromatography technology	Dankert JF (2016), Dankert JF (2016)	2
SLBP	0	CDK1	0	affinity chromatography technology	Dankert JF (2016)	1
UPF1	8	NCBP1	7	affinity chromatography technology	Yamashita A (2009)	1
CUL1	7	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina SA (1998), Huttlin EL (2015), Huttlin EL (2017)	4
CCNA2	1	CDK4	2	affinity chromatography technology, affinity chromatography technology	Datta NS (1998), Kikuchi R (2014)	2
CDK1	0	CCNF	2	affinity chromatography technology	Kong M (2000)	1
SLBP	0	ERI1	5	two hybrid	Dominski Z (2003)	1
CDK2	0	CDK1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Huttlin EL (2017)	2
CCNA2	1	CDK6	0	affinity chromatography technology	Datta NS (1998)	1
CDK2	0	CDK6	0	biochemical, imaging technique	Cheng A (2000), Chen TC (2014)	2
SLBP	0	MIF4GD	1	affinity chromatography technology, affinity chromatography technology	Dankert JF (2016), Dankert JF (2016)	2
CCNA2	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Amador V (2007), Horton LE (1997), Lin ML (2011), Lin ML (2011), OConnor PM (1993), Varjosalo M (2013), Kikuchi R (2014), Mateo F (2009), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	13
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
ZFC3H1	6	UPF1	8	affinity chromatography technology	Huttlin EL (2017)	1
SLBP	0	FEM1C	2	affinity chromatography technology	Dankert JF (2017)	1
EIF4G1	9	NCBP1	7	affinity chromatography technology, affinity chromatography technology	McKendrick L (2001), Kroczynska B (2014)	2
SKP1	0	CCNF	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), DAngiolella V (2012), Yoshida Y (2011), Kuchay S (2017), Choudhury R (2017)	5
SLBP	0	CDK2	0	affinity chromatography technology	Dankert JF (2016)	1
CDK4	2	SLBP	0	enzymatic study	Anders L (2011)	1
ZFC3H1	6	SLBP	0	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A1	15	CDK1	0	enzymatic study	Russo GL (1992)	1
ZFC3H1	6	TACC3	1	affinity chromatography technology	Huttlin EL (2017)	1
TACC3	1	SLBP	0	affinity chromatography technology	Hein MY (2015)	1
SLBP	0	FEM1A	2	affinity chromatography technology	Dankert JF (2017)	1
SLBP	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Dankert JF (2016), Dankert JF (2016)	2
SLBP	0	CCNA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dankert JF (2017), Dankert JF (2016), Dankert JF (2016)	3
SLBP	0	CCNF	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dankert JF (2017), Dankert JF (2016), Dankert JF (2016), Dankert JF (2016)	4
SLBP	0	ZCCHC6	2	affinity chromatography technology	Dankert JF (2016)	1
8339	0	SLBP	0	bioid	Lambert JP (2015)	1
CUL4A	2	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), He YJ (2006), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Huttlin EL (2017), Lo JY (2017)	10
CUL1	7	CCNA2	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Hein MY (2015)	2
P4HA3	3	SLBP	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL1	7	CDK4	2	affinity chromatography technology	Bennett EJ (2010)	1
CDK2	0	SKP1	0	x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao ZP (2006), Lyapina SA (1998), Zhang H (1995), Varjosalo M (2013), So J (2015), Hein MY (2015)	6
SLBP	0	CUL1	7	affinity chromatography technology	Dankert JF (2016)	1
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
CUL2	3	FEM1A	2	affinity chromatography technology	Bennett EJ (2010)	1
SLBP	0	CTIF	2	affinity chromatography technology, affinity chromatography technology	Dankert JF (2017), Dankert JF (2016)	2
MIF4GD	1	CTIF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FEM1B	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Bennett EJ (2010), Kamura T (2004), Kamura T (2004)	4
CCNA2	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Naderi S (2005), Varshochi R (2005), Di Fiore B (2010), Mateo F (2009), Abbas T (2007), Schulman BA (1998), Datta NS (1998), Wu G (1997), Sebastian B (1993), Liu S (2009), Ciarallo S (2002), Wolthuis R (2008), Vicent GP (2011), Zhang H (1995), Sayle KL (2003), Jeffrey PD (1995), Davies TG (2001), Cook A (2002), Pevarello P (2006), Levkau B (1998), Poon RY (1996), OConnor PM (1993), Davies TG (2002), Kontopidis G (2003), Andrews MJ (2004), Pevarello P (2004), Pevarello P (2005), Varjosalo M (2013), Varjosalo M (2013), Kikuchi R (2014), Kikuchi R (2014), Mateo F (2009), So J (2015), Okamoto K (2002), Song MS (2011), Huttlin EL (2015), Di Fiore B (2015), Pan ZQ (1993), Pan ZQ (1993), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	43
8339	0	CCNA2	1	bioid	Lambert JP (2015)	1
CUL4A	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
SLBP	0	NCBP1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dankert JF (2017), Dankert JF (2016), Dankert JF (2016)	3
SLBP	0	FEM1B	1	affinity chromatography technology	Dankert JF (2017)	1
CSNK2A1	15	ZFC3H1	6	enzymatic study	Zhang M (2011)	1
8339	0	CUL4A	2	bioid	Lambert JP (2015)	1