PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZNF408	0	CRELD1	0	two hybrid	Lehner B (2004)	1
POLA2	2	SETDB1	3	two hybrid	Stelzl U (2005)	1
ADGRG5	1	CRELD1	0	affinity chromatography technology	Huttlin EL (2017)	1
CD27	1	CRELD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CRELD1	0	PTN	0	two hybrid	Stelzl U (2005)	1
CRELD1	0	GDF9	2	two hybrid	Stelzl U (2005)	1
EIF6	2	CRELD1	0	two hybrid	Stelzl U (2005)	1
ATP5J2	0	CRELD1	0	two hybrid	Stelzl U (2005)	1
LPAR1	1	CRELD1	0	affinity chromatography technology	Huttlin EL (2015)	1
PARP16	1	CRELD1	0	affinity chromatography technology	Huttlin EL (2015)	1
KAT5	1	MAP3K1	4	affinity chromatography technology	Zhu P (2006)	1
CRELD1	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
P2RY12	0	CRELD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HTR3A	1	CRELD1	0	affinity chromatography technology	Huttlin EL (2017)	1
CRELD1	0	EEF1G	0	two hybrid	Stelzl U (2005)	1
FZD10	5	CRELD1	0	affinity chromatography technology	Huttlin EL (2017)	1
CRELD1	0	KAT5	1	two hybrid	Stelzl U (2005)	1
PTGER3	2	CRELD1	0	affinity chromatography technology	Huttlin EL (2015)	1
MAP3K1	4	CRELD1	0	enzymatic study	Charlaftis N (2014)	1
MTNR1B	1	CRELD1	0	two hybrid	Benleulmi-Chaachoua A (2016)	1
CRELD1	0	COPS6	0	two hybrid	Stelzl U (2005)	1
EIF6	2	POLA2	2	two hybrid	Stelzl U (2005)	1
CRELD1	0	POLA2	2	two hybrid	Stelzl U (2005)	1