PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZSCAN5A	1	RCOR1	0	affinity chromatography technology	Huttlin EL (2017)	1
ZMYM2	5	RCOR1	0	affinity chromatography technology, pull down	Gocke CB (2008), Gocke CB (2008)	2
CSNK2A2	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Gao Z (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
ZSCAN5A	1	CSNK2A1	15	affinity chromatography technology	Huttlin EL (2017)	1
ZSCAN5A	1	RCOR3	0	affinity chromatography technology	Huttlin EL (2017)	1
ZSCAN5A	1	ZMYM4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	3
ZSCAN5A	1	CSNK2B	5	affinity chromatography technology	Huttlin EL (2017)	1
OBSL1	9	HMGA1	0	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	CSNK2A1	15	affinity chromatography technology	Hanson D (2014)	1
ZSCAN5A	1	APP	1	pull down	Olah J (2011)	1
OBSL1	9	CSNK2B	5	affinity chromatography technology	Hanson D (2014)	1
KDM1A	2	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cui S (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013)	4
ZSCAN5A	1	NCOR2	12	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A1	15	NCOR1	9	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yoo JY (2012), Yoo JY (2012), Yoo JY (2012)	3
RCOR3	0	APP	1	pull down	Olah J (2011)	1
OBSL1	9	KDM1A	2	affinity chromatography technology	Hanson D (2014)	1
APP	1	HMGA1	0	pull down	Virok DP (2011)	1
ZSCAN5A	1	CDYL2	4	affinity chromatography technology	Hein MY (2015)	1
CSNK2A2	1	KDM1A	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Peng B (2015), Peng B (2015), Peng B (2015), Peng B (2015)	4
ZSCAN5A	1	IPO8	9	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
KDM1A	2	RCOR3	0	affinity chromatography technology, two hybrid, biochemical	Bantscheff M (2011), Weimann M (2013), Wan C (2015)	3
ZMYM4	4	KDM1A	2	affinity chromatography technology	Hauri S (2016)	1
ZSCAN5A	1	ZNF616	0	affinity chromatography technology	Hein MY (2015)	1
HDAC3	5	RCOR1	0	affinity chromatography technology	Joshi P (2013)	1
ZSCAN5A	1	HDAC3	5	affinity chromatography technology	Huttlin EL (2017)	1
NCOR2	12	HMGA1	0	affinity chromatography technology	Bloch M (2012)	1
CSNK2A1	15	KDM1A	2	affinity chromatography technology	Peng B (2015)	1
ZSCAN5A	1	NCOR1	9	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A1	15	HDAC3	5	enzymatic study, affinity chromatography technology	Zhang X (2005), Rajendran P (2011)	2
ZSCAN5A	1	HMGA1	0	affinity chromatography technology	Hein MY (2015)	1
ZMYM4	4	RCOR1	0	affinity chromatography technology	Hauri S (2016)	1
CSNK2A1	15	APP	1	pull down	Olah J (2011)	1
CSNK2B	5	CSNK2A2	1	two hybrid, affinity chromatography technology, far western blotting, two hybrid, enzymatic study, biochemical, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lehner B (2004), Kim MS (1998), Marin O (1997), Bosc DG (2000), Watabe M (2011), Havugimana PC (2012), Wang J (2011), Kristensen AR (2012), Varjosalo M (2013), Wallach T (2013), Hein MY (2015), Goetz C (1999), Hauri S (2016)	13
RCOR1	0	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Gocke CB (2008), Chen Y (2006), Yang M (2006), Shi YJ (2005), Shi YJ (2005), Lee MG (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Hwang S (2011), Lin Y (2010), Nicholson TB (2011), Nicholson TB (2011), Cui S (2011), Adamo A (2011), Adamo A (2011), Bantscheff M (2011), Mosammaparast N (2013), Lin Y (2010), Wan C (2015), Boldt K (2016)	25
HDAC3	5	RCOR3	0	affinity chromatography technology	Joshi P (2013)	1
ZSCAN5A	1	RCOR2	3	affinity chromatography technology	Huttlin EL (2017)	1
ZSCAN5A	1	KDM1A	2	affinity chromatography technology	Huttlin EL (2017)	1
ZSCAN5A	1	EPHB4	3	affinity chromatography technology	Hein MY (2015)	1
NCOR1	9	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Fischle W (2002), Fischle W (2002), Fischle W (2001), Zhang J (2002), Zhang J (2002), Zhang J (2002), Li J (2000), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Alenghat T (2006), Jiang S (2006), Wen YD (2000), Wen YD (2000), Wen YD (2000), Liu XF (2004), Yoon HG (2005), Yoon HG (2005), Zhu P (2006), Bantscheff M (2011), Joshi P (2013)	26
ZSCAN5A	1	CSNK2A2	1	affinity chromatography technology	Huttlin EL (2017)	1
ZMYM2	5	ZMYM4	4	affinity chromatography technology, affinity chromatography technology	Gocke CB (2008), Hauri S (2016)	2
EPHB4	3	APP	1	pull down	Olah J (2011)	1
NCOR2	12	NCOR1	9	biochemical, two hybrid	Li J (2000), Korutla L (2005)	2
ZSCAN5A	1	ZMYM2	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
KDM1A	2	ZMYM2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Gocke CB (2008), Shi YJ (2005), Lee MG (2005)	4
ZSCAN5A	1	SCAND1	1	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A1	15	HMGA1	0	enzymatic study, enzymatic study	Zhang M (2011), Piekielko A (2001)	2
ZSCAN5A	1	MRPS12	0	affinity chromatography technology	Hein MY (2015)	1
NCOR2	12	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Guenther MG (2000), Guenther MG (2000), Guenther MG (2000), Fischle W (2002), Fischle W (2002), Guenther MG (2002), Guenther MG (2002), Guenther MG (2002), Guenther MG (2002), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Guenther MG (2000), Guenther MG (2000), Kim MY (2006), Wang L (2006), Torres-Padilla ME (2002), Codina A (2005), Wen YD (2000), Rajendran P (2011), Liu A (2006), Bantscheff M (2011), Joshi P (2013), Xu F (2016)	27
ZSCAN5A	1	OBSL1	9	affinity chromatography technology	Huttlin EL (2017)	1
APP	1	OBSL1	9	affinity chromatography technology	Huttlin EL (2017)	1