Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
ALDH5A1	7915	CHLORMERODRIN	CHEMBL2110562	inhibitor	DrugBank	11752352, 17139284, 17016423, 5692397
ALDH5A1	7915	VALPROATE SODIUM	CHEMBL433	inhibitor	ChemblInteractions
ALDH5A1	7915	VALPROIC ACID	CHEMBL109	inhibitor	ChemblInteractions
ALDH5A1	7915	SUCCINIC ACID	CHEMBL576	inhibitor	DrugBank, TTD	15853764, 11752352, 16942602, 17619587, 17584458, 16689938
ALDH5A1	7915	CHEMBL1161866	CHEMBL1161866		DrugBank	17139284, 17016423
ALDH5A1	7915	DIVALPROEX SODIUM	CHEMBL2105613	inhibitor	ChemblInteractions
ALDH5A1	7915	CHEMBL378577	CHEMBL378577	inhibitor	GuideToPharmacologyInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
ALDH5A1	rs2760118	CT + TT	methadone	efficacy	yes	Patients carrying the T allele were at a higher risk of being a non-responder to methadone treatment as compared to those with the CC genotype. Responders defined as those who had negative results for illicit opioids in all of the last four urine tests. Nonresponders were those with two or more positive results in the last four urine tests. Responders also had a significantly higher mean methadone dose (p=0.001) and a mean number of months in the methadone maintenance treatment (MMT) program (p=0.009). However, when controlling for these two variables, the association between genotype and response remained statistically significant (p=0.0049).	Genotypes CT + TT is associated with decreased response to methadone in people with Opioid-Related Disorders as compared to genotype CC.	24230997	1444698532