PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SUV39H1	0	PRMT6	2	two hybrid	Weimann M (2013)	1
ZNF557	3	NSD3	6	two hybrid	Weimann M (2013)	1
CRK	0	ZNF557	3	two hybrid	Grossmann A (2015)	1
ZNF557	3	SMYD3	0	two hybrid	Weimann M (2013)	1
ZNF557	3	CEP70	1	two hybrid	Yu H (2011)	1
STAT3	0	ZNF557	3	two hybrid	Grossmann A (2015)	1
MTUS2	4	ZNF557	3	two hybrid	Yu H (2011)	1
SMAD9	0	ZNF557	3	two hybrid	Colland F (2004)	1
SUV39H2	3	CEP70	1	two hybrid, two hybrid	Vinayagam A (2011), Weimann M (2013)	2
SMAD9	0	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
SUV39H1	0	CEP70	1	two hybrid	Rolland T (2014)	1
ZNF557	3	SUV39H1	0	two hybrid	Weimann M (2013)	1
ZNF557	3	SUV39H2	3	two hybrid	Weimann M (2013)	1
ZNF557	3	PRMT6	2	two hybrid	Weimann M (2013)	1