PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LNPEP	1	GCC1	1	affinity chromatography technology	Hein MY (2015)	1
ITSN1	5	SCOC	3	two hybrid	Wong KA (2012)	1
SMC1A	15	PRPF19	2	affinity chromatography technology	Hein MY (2015)	1
PAK5	0	LZTS2	4	two hybrid	Rual JF (2005)	1
MCRS1	1	BRCA1	7	two hybrid, affinity chromatography technology	Hill SJ (2014), Hill SJ (2014)	2
KIAA1217	7	GCC1	1	two hybrid	Rual JF (2005)	1
NAV1	5	APP	1	pull down	Olah J (2011)	1
GCC1	1	MTHFD2	0	biochemical	Havugimana PC (2012)	1
SMC1A	15	GCC1	1	affinity chromatography technology	Hein MY (2015)	1
NINL	1	LZTS2	4	two hybrid, bioid	Rual JF (2005), Gupta GD (2015)	2
MCRS1	1	GCC1	1	two hybrid	Venkatesan K (2009)	1
CEP57	0	PRPF19	2	affinity chromatography technology	Fogeron ML (2013)	1
GCC1	1	CEP70	1	two hybrid	Rolland T (2014)	1
MCRS1	1	CCDC85B	0	two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Du X (2006), Du X (2006)	3
COIL	1	GCC1	1	two hybrid	Lim J (2006)	1
GCC1	1	ZNF276	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
GCC1	1	LZTS2	4	two hybrid	Rolland T (2014)	1
TINF2	1	GCC1	1	affinity chromatography technology	Hein MY (2015)	1
CEP57	0	RALBP1	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
GLI1	3	GCC1	1	two hybrid	Rolland T (2014)	1
CEP57	0	GCC1	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ATF4	2	GCC1	1	two hybrid	Rolland T (2014)	1
AMOTL2	5	GCC1	1	two hybrid	Rual JF (2005)	1
TFIP11	5	GCC1	1	two hybrid	Rolland T (2014)	1
TRIM29	2	GCC1	1	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
ATN1	2	GCC1	1	two hybrid	Lim J (2006)	1
CCDC85B	0	GCC1	1	two hybrid	Rual JF (2005)	1
GCC1	1	CPSF7	4	two hybrid	Rual JF (2005)	1
GOLGA2	2	GCC1	1	two hybrid	Rolland T (2014)	1
TMEM132A	1	GCC1	1	affinity chromatography technology	Hein MY (2015)	1
KIAA0753	1	GCC1	1	two hybrid	Rolland T (2014)	1
SPOP	1	AMOTL2	5	two hybrid	Zhang P (2017)	1
TMEM17	0	LNPEP	1	bioid	Gupta GD (2015)	1
GOLGA2	2	AMOTL2	5	two hybrid	Rolland T (2014)	1
BRCA1	7	PRPF19	2	affinity chromatography technology	Ertych N (2016)	1
GTF2I	1	GCC1	1	two hybrid	Corominas R (2014)	1
ABI2	4	KIAA1217	7	two hybrid	Rolland T (2014)	1
TRIM29	2	LZTS2	4	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRIM29	2	FBF1	2	two hybrid	Rual JF (2005)	1
SMARCD1	5	CCDC85B	0	two hybrid	Rual JF (2005)	1
RALBP1	2	IKBKG	0	imaging technique	Chen TC (2014)	1
GCC1	1	USHBP1	1	two hybrid	Rual JF (2005)	1
BRCA1	7	GTF2I	1	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Tanikawa M (2011), Tanikawa M (2011), Tanikawa M (2011), Tanikawa M (2011)	4
GCC1	1	NAV1	5	two hybrid	Rolland T (2014)	1
PRPF19	2	TFIP11	5	affinity chromatography technology	Huttlin EL (2017)	1
GCC1	1	APP	1	pull down	Olah J (2011)	1
ABI2	4	GCC1	1	two hybrid	Rolland T (2014)	1
GOLGA2	2	TRIM29	2	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
TMEM17	0	GCC1	1	bioid	Gupta GD (2015)	1
BRCA1	7	DNAJA3	2	unspecified method	Rodriguez M (2003)	1
ARL1	0	GCC1	1	two hybrid	Lu L (2003)	1
BIRC2	1	GCC1	1	two hybrid	Rolland T (2014)	1
DNAJA3	2	GCC1	1	two hybrid	Rolland T (2014)	1
SCOC	3	GCC1	1	affinity chromatography technology	Huttlin EL (2017)	1
NINL	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Jin S (2009), Jin S (2009)	2
ITSN1	5	GCC1	1	two hybrid	Wong KA (2012)	1
GCC1	1	SPOP	1	two hybrid	Yu H (2011)	1
CEP57	0	TFIP11	5	two hybrid	Rolland T (2014)	1
ATF4	2	APP	1	pull down	Olah J (2011)	1
PAK5	0	GCC1	1	two hybrid	Rolland T (2014)	1
RALBP1	2	GCC1	1	affinity chromatography technology	Huttlin EL (2017)	1
MCRS1	1	USHBP1	1	two hybrid	Rolland T (2014)	1
CCDC85B	0	LZTS2	4	two hybrid	Rual JF (2005)	1
OIP5	1	C1orf94	1	two hybrid	Rolland T (2014)	1
GCC1	1	FBF1	2	two hybrid, affinity chromatography technology, bioid	Rual JF (2005), Rual JF (2005), Gupta GD (2015)	3
GCC1	1	IKBKG	0	two hybrid	Wang J (2011)	1
SMC1A	15	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yazdi PT (2002), Hill SJ (2014), Ertych N (2016)	3
KIAA0753	1	USHBP1	1	two hybrid	Rolland T (2014)	1
OIP5	1	TFIP11	5	two hybrid	Rolland T (2014)	1
RALBP1	2	AMOTL2	5	two hybrid	Rolland T (2014)	1
ATP6V1B2	3	GCC1	1	biochemical	Wan C (2015)	1
GCC1	1	C1orf94	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
NECAB2	1	USHBP1	1	two hybrid	Yu H (2011)	1
NAB2	2	GCC1	1	two hybrid	Rolland T (2014)	1
COIL	1	APP	1	pull down	Olah J (2011)	1
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
CCDC85B	0	CEP70	1	two hybrid	Rual JF (2005)	1
USHBP1	1	FBF1	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
GCC1	1	SMARCD1	5	two hybrid	Wang J (2011)	1
GOLGA2	2	FBF1	2	two hybrid	Rolland T (2014)	1
ABI2	4	TFIP11	5	two hybrid	Rolland T (2014)	1
CCDC85B	0	FBF1	2	two hybrid	Rual JF (2005)	1
OIP5	1	GCC1	1	two hybrid	Rolland T (2014)	1
PRPF19	2	GCC1	1	affinity chromatography technology	Huttlin EL (2017)	1
7515	0	GCC1	1	affinity chromatography technology	Hein MY (2015)	1
FBF1	2	APP	1	pull down	Olah J (2011)	1
CEP57	0	APP	1	pull down	Olah J (2011)	1
GCC1	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
NECAB2	1	GCC1	1	two hybrid	Rolland T (2014)	1
JPH4	4	GCC1	1	affinity chromatography technology	Huttlin EL (2017)	1
LLGL2	4	GCC1	1	affinity chromatography technology	Hein MY (2015)	1
SMARCD1	5	USHBP1	1	two hybrid	Rual JF (2005)	1
COIL	1	CEP70	1	two hybrid	Lim J (2006)	1
GOLGA2	2	KIAA1217	7	two hybrid	Rolland T (2014)	1
COIL	1	DNAJA3	2	two hybrid	Lim J (2006)	1
LZTS2	4	FBF1	2	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
TRIM29	2	CEP70	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NINL	1	KIAA1217	7	bioid	Gupta GD (2015)	1
NINL	1	KIAA0753	1	bioid	Gupta GD (2015)	1
NINL	1	GCC1	1	two hybrid	Rual JF (2005)	1
IKBKG	0	TRIM29	2	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ravasi T (2010), Xing J (2016), Xing J (2016), Xing J (2016)	4
TMEM132A	1	GOLGA2	2	affinity chromatography technology	Hein MY (2015)	1